Abstract
The dynamics of the growth of Ehrlich ascites carcinoma in mice of the SHK line exposed to hypofractionated high-dose irradiation by a thin scanning proton beam has been analyzed for different irradiation volumes and different time intervals (from 4 to 24 hours) between two 30-Gy fractions. Irradiation of the gross tumor volume and the planned target volume was performed within the Bragg peak; the energy of protons at the outlet of the accelerator ranged from 85 to 100 MeV. Hypofractionated irradiation of the gross tumor volume of Ehrlich ascites carcinoma resulted in a more pronounced antitumor effect than the irradiation of the planned target volume. The effect did not depend on the interval between the irradiation episodes.
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Abbreviations
- GTV:
-
gross tumor volume
- PTV:
-
planned target volume
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Original Russian Text © V.E. Balakin, A.E. Shemyakov, S.I. Zaichkina, O.M. Rozanova, E.N. Smirnova, S.P. Romanchenko, S.S. Sorokina, N.S. Strelnikova, 2016, published in Biofizika, 2016, Vol. 61, No. 4, pp. 808–812.
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Balakin, V.E., Shemyakov, A.E., Zaichkina, S.I. et al. Hypofractionated irradiation of the solid form of Ehrlich ascites carcinoma in mice by a thin scanning proton beam. BIOPHYSICS 61, 682–686 (2016). https://doi.org/10.1134/S0006350916040047
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DOI: https://doi.org/10.1134/S0006350916040047