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Characteristic Features of Protein Interaction with Single- and Double-Stranded RNA

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Abstract

The review discusses differences between the specific protein interactions with single- and double-stranded RNA molecules using the data on the structure of RNA–protein complexes. Proteins interacting with the single-stranded RNAs form contacts with RNA bases, which ensures recognition of specific nucleotide sequences. Formation of such contacts with the double-stranded RNAs is hindered, so that the proteins recognize unique conformations of the RNA spatial structure and interact mainly with the RNA sugar-phosphate backbone.

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Abbreviations

dsRBD:

double-stranded RNA-binding domain

dsRNA:

double-stranded RNA

RNP:

ribonucleoprotein

ssRNA:

single-stranded RNA

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Acknowledgments

The author is grateful to S. V. Tishchenko for helpful discussion during writing of this review and to S. V. Nikonov, M. B. Garber, and N. A. Nevskaya for the fundamental studies that served as a foundation for this work.

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  1. Institute of Protein Research, Russian Academy of Sciences, 142290, Pushchino, Moscow Region, Russia

    Alexey D. Nikulin

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Nikulin, A.D. Characteristic Features of Protein Interaction with Single- and Double-Stranded RNA. Biochemistry Moscow 86, 1025–1040 (2021). https://doi.org/10.1134/S0006297921080125

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