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Mechanisms of long-term plasticity of hippocampal GABAergic synapses

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Abstract

Long-term potentiation and depression of synaptic transmission have been considered as cellular mechanisms of memory in studies conducted in recent decades. These studies were predominantly focused on mechanisms underlying plasticity at excitatory synapses. Nevertheless, normal central nervous system functioning requires maintenance of a balance between inhibition and excitation, suggesting existence of similar modulation of glutamatergic and GABAergic synapses. Here we review the involvement of G-protein-coupled receptors in the generation of long-term changes in synaptic transmission of inhibitory synapses. We considered the role of endocannabinoid and glutamate systems, GABAB and opioid receptors in the induction of long-term potentiation and long-term depression in inhibitory synapses. The preand postsynaptic effects of activation of these receptors are also discussed.

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Abbreviations

AMPA receptors/channels:

α-amino-3hydroxy-5-methyl-4-isoxazolepropionic acid-sensitive glutamate receptors/channels

CaMKII:

calmodulin-dependent protein kinase II

CB1 and CB2:

cannabinoid receptors of types 1 and 2, respectively

CNS:

central nervous system

DSI:

depolarization-induced suppression of inhibition

GABA:

gammaaminobutyric acid

LTD:

long-term depression

LTP:

longterm potentiation

NMDA receptors/channels:

glutamate Nmethyl-D-aspartate receptors/channels

PKA:

cAMP-dependent protein kinase A

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Author information

Authors and Affiliations

  1. Kazan Federal University, OpenLab of Neurobiology, 420008, Kazan, Russia

    A. V. Rozov & F. F. Valiullina

  2. Division of Neuro- and Sensory Physiology, Institute of Physiology and Pathophysiology, Heidelberg University, 69120, Heidelberg, Germany

    A. V. Rozov

  3. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485, Moscow, Russia

    A. P. Bolshakov

  4. Russian National Research Medical University, 117997, Moscow, Russia

    A. P. Bolshakov

Authors
  1. A. V. Rozov
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  2. F. F. Valiullina
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  3. A. P. Bolshakov
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Correspondence to A. P. Bolshakov.

Additional information

Original Russian Text © A. V. Rozov, F. F. Valiullina, A. P. Bolshakov, 2017, published in Biokhimiya, 2017, Vol. 82, No. 3, pp. 389-396.

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Rozov, A.V., Valiullina, F.F. & Bolshakov, A.P. Mechanisms of long-term plasticity of hippocampal GABAergic synapses. Biochemistry Moscow 82, 257–263 (2017). https://doi.org/10.1134/S0006297917030038

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  • DOI: https://doi.org/10.1134/S0006297917030038

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