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Extracellular actin in health and disease

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Abstract

This review considers the functions of extracellular actin–cell surface bound, associated with extracellular matrix, or freely circulating. The role of this protein in different pathological processes is analyzed: its toxic effects and involvement in autoimmune diseases as an autoantigen. The extracellular actin clearance system and its role in protection against the negative effects of actin are characterized. Levels of free-circulating actin, anti-actin immunoglobulins, and components of the actin clearance system as prognostic biomarkers for different diseases are reviewed. Experimental approaches to protection against excessive amounts of free-circulating F-actin are discussed.

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Abbreviations

DAMPs:

danger-associated molecular patterns

Ig:

immunoglobulins

PCD:

programmed cell death

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Authors and Affiliations

  1. Irkutsk Surgery and Traumatology Research Center, 664003, Irkutsk, Russia

    N. P. Sudakov, V. A. Byvaltsev & S. B. Nikiforov

  2. Irkutsk Research Center, Siberian Branch of the Russian Academy of Sciences, 664033, Irkutsk, Russia

    N. P. Sudakov

  3. Irkutsk State University, 664003, Irkutsk, Russia

    N. P. Sudakov, I. V. Klimenkov & Yu. M. Konstantinov

  4. Limnological Institute, Siberian Branch of the Russian Academy of Sciences, 664033, Irkutsk, Russia

    N. P. Sudakov & I. V. Klimenkov

  5. Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch of the Russian Academy of Sciences, 664033, Irkutsk, Russia

    Yu. M. Konstantinov

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Original Russian Text © N. P. Sudakov, I. V. Klimenkov, V. A. Byvaltsev, S. B. Nikiforov, Yu. M. Konstantinov, 2017, published in Biokhimiya, 2017, Vol. 82, No. 1, pp. 5-18.

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Sudakov, N.P., Klimenkov, I.V., Byvaltsev, V.A. et al. Extracellular actin in health and disease. Biochemistry Moscow 82, 1–12 (2017). https://doi.org/10.1134/S0006297917010011

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