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Possible interventions to modify aging

  • Phenoptosis (Special Issue)
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Abstract

The programmed aging paradigm interprets aging as a function favored by natural selection at a supra-individual level. This function is implemented, according to the telomere theory, through mechanisms that operate through the subtelomere–telomere–telomerase system. After reviewing some necessary technical and ethical reservations and providing a concise description of aging mechanisms, this work considers interventions that could lead to the control of some highly disabling characteristics of aging, such as Alzheimer’s and Parkinson’s syndromes and age-related macular degeneration, and afterwards to a full control of aging up to a condition equivalent to that of the species defined as “with negligible senescence”. The various steps needed for the development of such interventions are described along general lines.

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  1. Federico II University, Department of Translational Medical Sciences, 80138, Naples, Italy

    Giacinto Libertini & Nicola Ferrara

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  1. Giacinto Libertini
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Correspondence to Giacinto Libertini.

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Published in Russian in Biokhimiya, 2016, Vol. 81, No. 12, pp. 1685–1702.

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Libertini, G., Ferrara, N. Possible interventions to modify aging. Biochemistry Moscow 81, 1413–1428 (2016). https://doi.org/10.1134/S0006297916120038

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