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Recent strategies to improve boron dipyrromethene (BODIPY) for photodynamic cancer therapy: an updated review

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Abstract

BODIPYs are photosensitizers activatable by light to generate highly reactive singlet oxygen (1O2) from molecular oxygen, leading to tissue damage in the photoirradiated region. Despite their extraordinary photophysical characteristics, they are not featured in clinical photodynamic therapy. This review discusses the recent advances in the design and/or modifications of BODIPYs since 2013, to improve their potential in photodynamic cancer therapy and related areas.

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Acknowledgments

This research study was supported by Postgraduate Research Grant (PPP) — Research, project no. PG222-2016A.

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Authors and Affiliations

  1. Department of Diagnostic and Allied Health Sciences, Faculty of Health and Life Sciences, Management & Science University, 40100 Shah Alam, Selangor, Malaysia

    Chin Siang Kue

  2. Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Shie Yin Ng, Lip Yong Chung & Hong Boon Lee

  3. Project Leadership, Clinical Operations, R&D Solutions, IQVIA, 50480, Kuala Lumpur, Malaysia

    Siew Hui Voon

  4. School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand

    Anyanee Kamkaew

  5. Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Lik Voon Kiew

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  1. Chin Siang Kue
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  2. Shie Yin Ng
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  4. Anyanee Kamkaew
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Correspondence to Lip Yong Chung or Hong Boon Lee.

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Kue, C.S., Ng, S.Y., Voon, S.H. et al. Recent strategies to improve boron dipyrromethene (BODIPY) for photodynamic cancer therapy: an updated review. Photochem Photobiol Sci 17, 1691–1708 (2018). https://doi.org/10.1039/c8pp00113h

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  • DOI: https://doi.org/10.1039/c8pp00113h

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