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Cellular Therapy

First report of pediatric hematopoietic stem cell transplantation activities in the eastern mediterranean region from 1984 to 2011: on behalf of the pediatric cancer working committee of the eastern mediterranean blood and marrow transplantation group

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Abstract

To describe the hematopoietic stem cell transplantation (HSCT) activities for children in the Eastern Mediterranean (EM) region, data on transplants performed for children less than 18 years of age between 1984 and 2011 in eight EM countries (Egypt, Iran, Jordan, Lebanon, Oman, Pakistan, Saudi Arabia and Tunisia) were collected. A total of 5187 transplants were performed, of which 4513 (87%) were allogeneic and 674 (13%) were autologous. Overall, the indications for transplantation were malignant diseases in 1736 (38.5%) and non-malignant in 2777 (61.5%) patients. A myeloablative conditioning regimen was used in 88% of the allografts. Bone marrow (BM) was the most frequent source of stem cells (56.2%), although an increasing use of PBSC was observed in the last decade. The stem cell source of autologous HSCT has shifted over time from BM to PBSC, and 80.9% of autologous HSCTs were from PBSCs. The donors for allogeneic transplants were matched-related in 94.5% of the cases, and unrelated transplants, mainly cord blood (99%) in 239 (5.5%) cases. This is the first report to describe the pediatric HSCT activities in EM countries. Non-malignant disorders are the main indication for allogeneic transplantation. Frequency of alternate donor transplantation is low.

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Acknowledgements

We acknowledge and thank all medical staff of the participating teams and their data managers who collected and forwarded their data to the corresponding author and EMBMT central office.

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Authors and Affiliations

  1. Bone Marrow and Stem Cell Transplantation Program, King Hussein Cancer Center, Amman, Jordan

    A A Hussein

  2. Hematology, Oncology and SCT Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

    A A Hamidieh, M Behfar & A Ghavamzadeh

  3. National Cancer Institute, Cairo University, Cairo, Egypt

    A Elhaddad, J Fathy & M Samra

  4. Shiraz University of Medical Science, Shiraz, Islamic Republic of Iran

    M Ramzi

  5. Center National de Greffe de Moelle Osseuse de Tunis, Tunis, Tunisia

    T B Othman & S Ladeb

  6. King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

    F Hussain, A Al-Ahmari, H El-Solh, M Ayas, M Aljurf & A Al-Seraihy

  7. Sultan Qaboos University Hospital, Muscat, Oman

    D Dennison & S Al-Kindi

  8. Armed Forces Bone Marrow Transplant Center, Rawalpindi, Pakistan

    P Ahmed

  9. American University Beirut Medical Center, Beirut, Lebanon

    M Abboud

  10. Queen Rania Al-Abdullah Children Hospital-King Hussein Medical Center, Amman, Jordan

    A Wahadneh

  11. Oran University-1st November Hospital, Oran, Algeria

    M-A Bekadja

  12. Service d’Hematologie et Oncologie Pediatrique, Casablanca, Morocco

    S Benchekroun

  13. Makassed General Hospital, Beirut, Lebanon

    A Ibrahim

  14. Aga Khan University Hospital, Karachi, Pakistan

    S Adil

Authors
  1. A A Hussein
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  2. A A Hamidieh
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  3. A Elhaddad
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  4. M Ramzi
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  5. T B Othman
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  6. F Hussain
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  7. D Dennison
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  8. P Ahmed
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  9. M Abboud
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  10. A Al-Ahmari
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  11. A Wahadneh
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  12. J Fathy
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  13. M-A Bekadja
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  14. S Al-Kindi
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  15. S Benchekroun
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  16. A Ibrahim
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  17. M Behfar
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  18. M Samra
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  19. S Ladeb
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  20. S Adil
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  21. H El-Solh
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  22. M Ayas
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  23. M Aljurf
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  24. A Ghavamzadeh
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  25. A Al-Seraihy
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Pediatric Cancer Working Committee of the Eastern Mediterranean Blood and Marrow Transplantation (EMBMT) Group

Corresponding author

Correspondence to A A Hussein.

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The authors declare no conflict of interest.

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Supplementary Information accompanies this paper on Bone Marrow Transplantation website

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Hussein, A., Hamidieh, A., Elhaddad, A. et al. First report of pediatric hematopoietic stem cell transplantation activities in the eastern mediterranean region from 1984 to 2011: on behalf of the pediatric cancer working committee of the eastern mediterranean blood and marrow transplantation group. Bone Marrow Transplant 52, 120–125 (2017). https://doi.org/10.1038/bmt.2016.209

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  • DOI: https://doi.org/10.1038/bmt.2016.209

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