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Lithium disturbs homeostasis of essential microelements in erythrocytes of rats: Selenium as a protective agent?

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Abstract

Background

Selenium is an essential element which shows protective properties against diverse harmful factors. Lithium compounds are widely used in medicine, but, in spite of undoubted beneficial effects, treatment with these compounds may lead to severe side effects, including renal, gastrointestinal, neurological, endocrine and metabolic disorders. This study was aimed at evaluating the influence of selenium and/or lithium on lithium, iron, zinc and copper content in rats’ erythrocytes as well as estimate the action of additional selenium on lithium exposure effects.

Methods

The experiment was performed on four groups of rats (six animals each): control — received saline; Li — received 2.7 mg Li/kg b.w. as lithium carbonate; Se — received 0.5 mg Se/kg b.w. as sodium selenite; Se + Li — received simultaneously 0.5 mg Se/kg b.w. and 2.7 mg Li/kg b.w. (sodium selenite and lithium carbonate). The administration was performed for three weeks, once a day by stomach tube, in form of water solutions. In erythrocytes the content of lithium, iron, zinc and copper was determined using flame atomic absorption spectroscopy.

Results

Lithium treatment insignificantly disturbed iron and zinc homeostasis as well as markedly increased lithium accumulation and copper content in rat erythrocytes. Selenium coadministration reversed those effects.

Conclusions

The beneficial effect of selenium on disturbances of studied microelements homeostasis as well as on preventing lithium accumulation in erythrocytes in Li receiving animals allows suggesting that further research on selenium application as an adjuvant in lithium therapy is worth carrying on.

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Author information

Authors and Affiliations

  1. Chair and Department of Medical Chemistry, Medical University of Lublin, Lublin, Poland

    Małgorzata Kiełczykowska, Joanna Kocot, Jacek Kurzepa & Irena Musik

  2. Chair and Department of Bromatology, Medical University of Lublin, Lublin, Poland

    Ewelina Kopciał & Zbigniew Marzec

Authors
  1. Małgorzata Kiełczykowska
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  2. Ewelina Kopciał
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  3. Joanna Kocot
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  5. Zbigniew Marzec
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  6. Irena Musik
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Correspondence to Joanna Kocot.

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Kiełczykowska, M., Kopciał, E., Kocot, J. et al. Lithium disturbs homeostasis of essential microelements in erythrocytes of rats: Selenium as a protective agent?. Pharmacol. Rep 70, 1168–1172 (2018). https://doi.org/10.1016/j.pharep.2018.05.003

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  • DOI: https://doi.org/10.1016/j.pharep.2018.05.003

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