Abstract
Eryngium creticum Lam. (E. cyaneum Sibth. & Sm., E. syriacum Lam.), Saniculoideae, Apiaceae is of great importance in the traditional Greco - Arab medicine. This study was carried out in order to contribute to the ethnopharmacological knowledge of this medicinal species. This review describes the botanical characterization and distribution, as well as critically assesses the phytochemical properties and biological activities of £ creticum, a species that has been used in traditional medicine for many decades. Possible trends and perspectives for future research of this plant are discussed, as well. E. creticum has been found to contain several chemical constituents, mostly sesquiterpenes, monoterpenes, aldehydes, coumarins, sitosterols and sugars. Eryngo with its bioactive compounds possesses a wild range of biological activities. It was reported that in traditional medicine E. creticum was applied mainly as the remedy for snake and scorpion bites. Some published studies have shown a broad spectrum of biological and pharmacological activities, including anti-snake and anti-scorpion venom, as well as antibacterial, antifungal and antileishmanial effects. Other have indicated antihyperglycemic, hypoglycemic and antioxidant activities of this species. The in vitro studies and in vivo models have provided a simple bioscientific explanation for its various ethnopharmacological uses.
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Abou-Jawdah, Y., Sobh, H., Salameh, A., 2002. Antimycotic activities of selected plant flora, growing wild in Lebanon, against phytopathogenic fungi. J. Agric. Food Chem. 50, 3208–3213.
Abu-Rabia, A., 2005. Herbs as a food and medicine source in Israel. Asian Pac. J. Cancer Prev. 6, 101–107.
Aburjai, T., Hudaib, M., Tayyem, R., Yousef, M., Qishawi, M., 2007. Ethnopharmacological survey of medicinal herbs in Jordan, the Ajloun Heights region. J Ethnopharmacol. 110, 294–304.
Afifi, F.U., Al-Khalil, M., Aqel, M., Al-Muhteseb, M.H., Jaghabir, M., Saket, M., Muheid, A., 1990. Antagonistic effect of Eryngium creticum extract on scorpion venom in vitro. J. Ethnopharmacol. 29, 43–49.
Al-Khalil, S., 1994. Phytochemistry of Eryngium creticum. Alex. J. Pharm. Sci. 8, 73–75.
Alkofahi, A., Sallal, A.J., Disi, A.M., 1997. Effect of Eryngium creticum on haemolytic activities of snake and scorpion venoms. Phytother Res. 11, 540–542.
Ali-Shtayeh, M.S., Abu Ghdeib, S.I., 1999. Antifungal activity of plant extracts against dermatophytes. Mycoses 42, 665–672.
Ali-Shtayeh, M.S., Yaghmour, R.M.R., Faidi, Y.R., Salem, K., Al-Nuri, M.A., 1998. Antimicrobial activity of 20 plants used in folkloric medicine in the Palestinian area. J Ethnopharmacol. 60, 265–271.
Ayoub, NA, Kubeczka, K.H., Nawwar, M.A.M., 2003. An unique n-propyl sesquiterpene from Eryngium creticum L. (Apiaceae). Pharmazie 58, 674–676.
Bunel, V., Ovedraogo, M., Nguyen, A.T., Stevigny, C., Duez, P., 2014. Methods applied to the in vitro primary toxicology testing of natural products: state of the art, strengths and limits. Planta Med. 80, 1210–1226.
Bustanji, Y., Issa, A., Moulay, A., Hudaib, M., Tawaha, K., Mohammad, M., Hamed, S., Masri, I., Alali, F.Q., 2011. Hormone sensitive lipase inhibition by selected medicinal plants. J. Med. Plants Res. 5, 4405–4410.
Caballero, R., Fernandez-Gonzalez, F., Badia, R.P., Molle, G., Roggero, P.P., Bagella, S., D’Ottavio, P., Papanastasis, V.P., Fotiadis, G., Sidiropoulou, A., Ispikoudis, I., 2009. Grazing systems and biodiversity in Mediterranean areas: Spain, Italy and Greece. Pastos XXXIX, 1–152.
Calvino, C.I., Martinez, S.G., Downie, S.R., 2008. The evolutionary history of Eryngium (Apiaceae, Saniculoideae): rapid radiations, long distance disperals, and hybridizations. Mol. Phylogenet Evol. 46, 1129–1150.
Celik, A., Ayddinlik, N., Arslan, I., 2011. Phytochemical constituents and inhibitory activity towards methicillin-resistant Staphylococcus aureus strains of Eryngium species (Apiaceae). Chem. Biodivers. 8, 454–459.
Dammous, M., Farhan, H., Rammal, H., Hijazji, A., Bassal, A., Fayyad-Kazan, H., Makhour, Y., Badran, B., 2014. Chemical composition of Lebanese Eryngium creticum L. Int. J. Sci. 3, 40–53.
Della, A., Paraskeva-Hadjichambi, D., Hadjichambis, A.Ch., 2006. An ethnobotanical survey of wild plants of Paphos and Larnaca countryside of Cyprus. J. Ethnobiol. Ethnomed., https://doi.org/10.1186/1746-4269-2-34.
Dirani, Z., Makki, R., Rammal, H., Naserddine, S., Hijazi, A., Kazan, H.F., Nasser, M., Daher, A., Badran, B., 2014. The antioxidant and anti-tumor activities of the Lebanese Eryngium creticum L. IJBPAS 3, 2199–2222.
Don, G., 1831. A general system of gardening and botany: containing a complete enumeration and description of all plants hitherto known with their generic and specific characters, places of growth, time of flowering, mode of culture and their uses in medicine and domestic economy: preceded by introductions to the Linnaean and Natural Systems and a glossary of the terms used: founded upon Miller’s Gardener’s Dictionary and arranged according to the Natural System: in four volumes, Tom 3(e-Book Google)., pp. 176–177.
El-Saket, M., 1990. Potency of Jordanian Cerastes cerastes snake venom and the effect of E. creticum on this potency. Bull. Fac. Pharm. Cairo Univ. 28, 53–55.
Erdem, S.A., Nabavi, S.F., Orhan, I.E., Daglia, M., Izadi, M., Nabavi, S.M., 2015. Blessings in disguise: a review of phytochemical composition and antimicrobial activity of plants belonging to the genus Eryngium. DARU J. Pharm. Sci. 23 (53), 1–22.
Farhan, H., Malli, F., Rammal, H., Hijazi, A., Bassal, A., Ajouz, N., Badran, B., 2012. Phytochemical screening and antioxidant activity of Lebanese Eryngium creticum L. Asian Pac. J. Trop. Biomed. 2, S1217–S1220.
Fokialakis, N., Kalpoutzakis, E., Tekwani, B.L., Khan, S.I., Kobaisy, M., Saltsounis, A.L., Duke, S.O., 2007. Evaluation of the antimalarial and antileishmanial activity of plants from the Greek island of Crete. J. Nat. Med. 61, 38–45.
Hijazi, A., Al Masri, D.S., Farhan, H., Nasser, M., Rammal, H., Annan, H., 2015. Effect of different ethanol concentrations, using different extraction techniques, on the antioxidant capacity of Lebanese Eryngium creticum. J. Pharm. Chem. Biol. Sci. 3, 262–271.
Jaghabir, M., 1991. Hypoglycemic effects oiEryngium creticum. Arch. Pharm. Res. 14, 295–297.
Jaghabir, M., Saket, M., Afifi, F., Khalis, S., Muheid, A., 1989. Potency of Jordan Leiurus quinguestriatus scorpion venom and the effect of Eryngium creticum on this potency. Dirasat 4, 172–178, Jordan University VI.
Jawdat, D., Al-Faoury, H., Ayyoubi, Z., Al-Safadi, B., 2010. Molecular and ecological study of Eryngium species in Syria. Biologia 65, 796–804.
Jeambey, Z., Johns, T., Talhouk, S., Batal, M., 2009. Perceived health and medicinal properties of six species of wild edible plants in north-east Lebanon. Public Health Nutr. 12, 1902–1911.
Kasabri, V., Afifi, F.U., Hamdan, I., 2011. Evaluation of the acute antihyperglycenic effects of four selected indigenous plants from Jordan used in traditional medicine. Pharm Biol. 49, 687–695.
Kasabri, V., Abu-Dahab, R., Aflfl, F.U., Naffa, R., Majdalawi, L, 2012. Modulation of pancreatic MIN6 insulin secretion and proliferation and extrapancreatic glucose absorption with Achillea santolina, Eryngium creticum and Pistacia atlantica extracts: in vitro evaluation. J. Exp. Integr Med. 2, 245–254.
Khader, M., Bresgen, N., Eckl, P.M., 2010. Antimutagenic effects of ethanolic extracts from selected Palestinian medicinal plants. J Ethnopharmacol. 127, 319–324.
Konig, Ch., Sims, J., 1806. Vegetable productions of the countries situated between the Terek and Kur. Ann. Bot., 426–428.
Lardos, A., 2012, May. Historical iatrasophia texts and modern plant usage in monasteries on Cyprus. A thesis. Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London.
Ljubuncic, P., Azaizeh, H., Portnaya, I., Cogan, U., Said, O., Abu Saleh, K., Bomzon, A., 2005. Antioxidant activity and cytotoxicity of eight plants used in traditional Arab medicine in Israel. J. Ethnopharmacol. 99, 43–47.
Makki, R., Dirani, Z.E., Rammal, H., Sweidan, A., Al Bazzal, A., Chokr, A., 2015. Antibacterial activity oftwo Lebanese plants: Eryngium creticum and Centranthus longiflorus. J. Nanomed. Nanotechnol., https://doi.org/10.4172/2157-7439.1000315.
Maries, R.J., Farnsworth, N.R., 1995. Antidiabetic plants and their active constituents. Phytomedicine 2, 137–189.
Mayer-Chissick, U., Lev, E., 2014. Wild edible plants in Israel tradition versus cultivation. In: Yaniv, Z., Dunat, N. (Eds.), Medicinal and Aromatic Plants of the Middle-East. Medicinal and Aromatic Plants of the World 2. Springer, Dordrecht/Heidelberg/New York/London, https://doi.org/10.1007/978-94-017-9276-9.
Mahommadhosseini, M., 2013. Hydrodistilled volatile oil from stems of Eryngium creticum Lam. in the Marginal Brackish Regions of Semnan Province by using gas chromatography combined with mass spectrometry. Asian J. Chem. 25, 390.
Mors, W.B., do Nascimento, M.C., Ruppelt Pereira, B.M., Alvares Pereira, N., 2000. Plant natural products active against snake bite - the molecular approach. Phy-tochemistry 55, 627–642.
Muschler, R., 1912. A Manual Flora of Egypt. Friedlaender R and Sohn, pp. 44–45.
Oukkache, N., El Jaoudi, R., Ghalim, N., Chgoury, F., Bouhaouala, B., Mdaghri, N.E., Sabatier, J.M., 2014. Evaluation of the lethal potency of scorpion and snake venoms and comparison between intraperitoneal and intravenous injection routes. Toxins (Basel) 12 (6), 1873–1881.
Palevitch, D., Yaniv, Z., Dafni, A., Friedman, J., 1985. Ethnobotanical Survey of the Flora of Israel as a Source for Drugs. Ministry of Science, Jerusalem (Hebrew).
Rammal, H., Fahran, H., Jamaleddine, N., El Mestrah, M., Nasser, M., Hijazi, A., 2015. Effects of altitude on the chemical composition and on some biological properties of Lebanese Eryngium creticum L. J. Chem. Pharm. Res. 7, 887–893.
Rammal, H., Farhan, H., Mohsen, H., Hijazi, A., Kobeissy, A., Daher, A., Badran, B., 2013. Antioxidant, cytotoxic properties and phytochemical screening oftwo Lebanese medicinal plants. Int. Res. J Pharm. 4, 132–136.
Saad, B., Azaizeh, H., Said, O., 2008. Arab herbal medicines. In: Preedy, V.R., Watson, R.R. (Eds.), Botanical Medicine in Clinical Practice. CAB International.
Saad, B., Said, O., 2011. Greco-Arab and Islamic herbal medicine. In: Traditional System, Ethics, Safety, Efficacy, and Regulatory Issues. John Wiley & Sons, Inc. Publication.
Thiem, B., Wiatrowska, I., 2007. Eryngium campestre L (field eryngo) and other species oiEryngium L. - little know medicinal plants. Herba Pol. 53, 93–102.
Tutin, T.G., Burges, D.H., Valentine, S.M., Walters, S.M., Webb, DA, 1968. Flora Europaea: Rosaceae to Umbelliferae. Cambridge University Press, pp. 321–322.
Twaij, H.A., Al-Dujaili, E.A.S., 2014. Evaluation of the Anti-diabetic and Anti-ulcer Properties of Some Jordanian and Iraqi Medicinal Plants: A Screening Study. IBIMA Publishing. JMED, https://doi.org/10.5171/2014.539605.
Wolff, H., 1913. Umbelliferae - Saniculoideae. In: Engler, A. (Ed.), Das Pflanzenreich, IV. 228 (heft 61). Engelmann W., Berlin, pp. 106–271.
Wörz, A., 1999. A taxonomic index of the species oiEryngium L. Stuttgarter Beiträge zur Naturkunde A 596, 1–48.
Wörz, A., 2004. Onthe distribution and relationships ofthe South-West Asian species of Eryngium L. (Apiaceae - Saniculoideae). Turk. J. Bot. 28, 85–92.
Wörz, A., 2005. A new subgeneric classification of the genus Eryngium L. (Apiaceae - Saniculoideae). Bot. Jahrb. Syst. 126, 253–259.
Wörz, A., 2006. Systematics and distribution patterns of the Balkan species oiEryngium (Apiaceae, Saniculoideae). Phytol. Balc. 12, 221–230.
Wörz, A., Diekmann, H., 2010. Classification and evolution of the genus Eryngium L. (Apiaceae - Saniculoideae): results of fruit anatomical and petal morphologies studies. Plant Divers Evol. 128, 387–408.
Yaniv, Z., Dafni, A., Friedman, J., Plevitch, D., 1987. Plants used for the treatment of diabetes in Israel. J. Ethnopharmacol. 19, 145–151.
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MK contributed in the review of the scientific bibliography using the following publishers websites and electronic databases to collect information on the subject: Elsevier, Springer, PubMed, Medline, Google Scholar and Web of Science. Additionally, she analyzed published monographs theses, and proceedings of scientific congresses. JK drew all the chemical formulas. JK, MD and BT participated in the critical reading and final editing of the manuscript.
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Kikowska, M., Dworacka, M., Kędziora, I. et al. Eryngium creticum - ethnopharmacology, phytochemistry and pharmacological activity. A review. Rev. Bras. Farmacogn. 26, 392–399 (2016). https://doi.org/10.1016/j.bjp.2016.01.008
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DOI: https://doi.org/10.1016/j.bjp.2016.01.008