Skip to main content
Log in

Anxiolysis for laceration repair in children: a survey of pediatric emergency providers in Canada

  • Original Research
  • Published:
Canadian Journal of Emergency Medicine Aims and scope Submit manuscript

Abstract

Objectives

Intranasal dexmedetomidine is a potentially effective anxiolytic but its role in pediatric laceration repair is only emerging. Future trials and clinical adoption of intranasal dexmedetomidine depend on understanding pediatric emergency providers’ practice patterns surrounding anxiolysis and perceived barriers to intranasal dexmedetomidine for anxiolysis during suture repair in children. Our objectives were to characterize these parameters to inform future research and facilitate clinical adoption.

Methods

We conducted an online survey of pediatric emergency physician members of Pediatric Emergency Research Canada from September to December 2020. Questions pertained to perceptions of anxiolysis for suture repair, with a focus on intranasal dexmedetomidine. The primary outcome was anxiolysis for suture repair. Data were reported using descriptive statistics.

Results

The response rate was 155/225 (68.9%). During suture repair, 127/148 (86%) believed that > 25% of young children experience distress requiring physical restraint. 116/148 (78%) would provide anxiolysis, mainly intranasal benzodiazepines (100/148, 68%). Only 6/148 (4%) would provide intranasal dexmedetomidine but 95/148 (64%) would consider it if there was evidence of benefit. The most common perceived barriers to intranasal dexmedetomidine included inadequate personal experience (114/145, 79%) and lack of access (60/145, 41%).

Conclusions

Most Canadian pediatric emergency providers believe that laceration repair in a young child is distressing. Despite questionable efficacy, most would provide intranasal benzodiazepines, but would consider intranasal dexmedetomidine if there was evidence of benefit.

Résumé

Objectifs

La dexmédétomidine intranasale est un anxiolytique potentiellement efficace mais son rôle dans la réparation des lacérations en pédiatrie n'est qu'émergent. Les futurs essais et l'adoption clinique de la dexmédétomidine intranasale dépendent de la compréhension des habitudes de pratique des urgentistes pédiatriques en matière d'anxiolyse et des obstacles perçus à la dexmédétomidine intranasale pour l'anxiolyse pendant la réparation des sutures chez les enfants. Nos objectifs étaient de caractériser ces paramètres pour éclairer les recherches futures et faciliter l'adoption clinique.

Méthodes

Nous avons mené un sondage en ligne auprès des médecins urgentistes pédiatriques membres de Recherche en urgence pédiatrique Canada (Pediatric Emergency Research Canada) de septembre à décembre 2020. Les questions portaient sur les perceptions de l'anxiolyse pour la réparation des sutures, en mettant l'accent sur la dexmédétomidine intranasale. Le résultat principal était l'anxiolyse pour la réparation des sutures. Les données ont été rapportées à l'aide de statistiques descriptives.

Résultats

Le taux de réponse était de 155/225 (68,9 %). Pendant la suture, 127/148 (86 %) ont estimé que > 25 % des jeunes enfants éprouvent une détresse nécessitant une contention physique. 116/148 (78 %) fourniraient une anxiolyse, principalement des benzodiazépines intranasales (100/148, 68 %). Seulement 6/148 (4 %) fourniraient de la dexmédétomidine intranasale, mais 95/148 (64 %) l’envisageraient s’il y avait une preuve de bénéfice. Les obstacles les plus fréquemment perçus à la dexmédétomidine intranasale étaient une expérience personnelle insuffisante (114/145, 79 %) et un manque d'accès (60/145, 41 %).

Conclusions

La plupart des fournisseurs canadiens de services d’urgence pédiatriques croient que la réparation des lacérations chez un jeune enfant est pénible. En dépit d'une efficacité douteuse, la plupart d'entre eux fourniraient des benzodiazépines intranasales, mais envisageraient la dexmédétomidine intranasale s'il était prouvé qu'elle était bénéfique.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Spiro D, Zonfrillo M, Meckler F. Wounds. Pediatr Rev. 2010;31(8):326–34.

    Article  Google Scholar 

  2. Neville DNW, Hayes KR, Ivan Y, McDowell ER, Pitetti RD. Double-blind randomized controlled trial of intranasal dexmedetomidine versus intranasal midazolam as anxiolysis prior to pediatric laceration repair in the emergency department. Acad Emerg Med. 2016;23:910–7.

    Article  Google Scholar 

  3. Doyon-Trottier E, Doré-Bergeron MJ, Chauvin-Kimoff L, Baerg K, Ali S. Managing pain and distress in children undergoing brief diagnostic and therapeutic procedures. Paediatr Child Health. 2019;24(8):509–21.

    Article  Google Scholar 

  4. Fein JA, Zempsky WT, Cravero JP. Relief of pain and anxiety in pediatric patients in emergency medical systems. Pediatrics. 2012;130(5):e1391–405.

    Article  Google Scholar 

  5. Miller JL, Capino AC, Thomas A, Couloures K, Johnson PN. Sedation and analgesia using medications delivered via the extravascular route in children undergoing laceration repair. J Pediatr Pharmacol Ther. 2018;23:72–83.

    PubMed  PubMed Central  Google Scholar 

  6. Poonai N, Spohn J, Vandermeer B, et al. Intranasal dexmedetomidine for anxiety-provoking procedures in children: a systematic review and meta-analysis. Pediatrics. 2020;145(1):e20191623.

    Article  Google Scholar 

  7. Conway A, Rolley J, Sutherland JR. Midazolam for sedation before procedures. Cochrane Database Syst Rev. 2016;5:CD009491. https://doi.org/10.1002/14651858.CD009491.pub2.

    Article  Google Scholar 

  8. Ashley PF, Chaudhary M, Lourenço-Matharu L. Sedation of children undergoing dental treatment. Cochrane Database Syst Rev. 2018;12(12):CD003877.

    PubMed  Google Scholar 

  9. Klein EJ, Brown JC, Kobayashi A, Osincup D, Seidel K. A randomized clinical trial comparing oral, aerosolized intranasal, and aerosolized buccal midazolam. Ann Emerg Med. 2011;58:323–9.

    Article  Google Scholar 

  10. Bar-Meir E, Zaslansky R, Regev E, Keidan I, Orenstein A, Winkler E. Nitrous oxide administered by the plastic surgeon for repair of facial lacerations in children in the emergency room. Plast Reconstr Surg. 2006;117(5):1571–5.

    Article  CAS  Google Scholar 

  11. Sulton C, McCracken C, Simon HK, et al. Pediatric procedural sedation using dexmedetomidine: a report from the Pediatric Sedation Research Consortium. Hosp Pediatr. 2016;6(9):536–44.

    Article  Google Scholar 

  12. Gupta A, Dalvi NP, Tendolkar BA. Comparison between intranasal dexmedetomidine and intranasal midazolam as premedication for brain magnetic resonance imaging in pediatric patients: a prospective randomized double blind trial. J Anaesthesiol Clin Pharmacol. 2017;33:236–40.

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Ghai B, Jain K, Saxena AK, Bhatia N, Sodhi KS. Comparison of oral midazolam with intranasal dexmedetomidine premedication for children undergoing CT imaging: a randomized, double-blind, and controlled study. Pediatr Anesth. 2017;27:37–44.

    Article  Google Scholar 

  14. Surendar MN, Pandey RK, Saksena AK, Kumar R, Chandra G. A comparative evaluation of intranasal dexmedetomidine, midazolam and ketamine for their sedative and analgesic properties: a triple blind randomized study. J Clin Pediatr Dent. 2014;38(3):255–61.

    Article  Google Scholar 

  15. Dillman DA. Mail and Internet Surveys. 2nd Edition. John Wiley & Sons Inc. (Hoboken, New Jersey). 2007.

  16. Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–81.

    Article  Google Scholar 

  17. Burns KE, Duffett M, Kho ME, et al. A guide for the design and conduct of self-administered surveys of clinicians. CMAJ. 2008;179(3):245–52.

    Article  Google Scholar 

  18. Malia L, Laurich VM, Sturm JJ. Adverse events and satisfaction with use of intranasal midazolam for emergency department procedures in children. Am J Emerg Med. 2019;37(1):85–8.

    Article  Google Scholar 

  19. Mellion SA, Bourne D, Brou L, et al. Evaluation clinical effectiveness and pharmacokinetics of atomized intranasal midazolam in children undergoing laceration repair. J Emerg Med. 2017;53(3):397–404.

    Article  Google Scholar 

  20. Theroux MC, West DW, Corddry DH, et al. Efficacy of intranasal midazolam in facilitating suturing of lacerations in preschool children in the emergency department. Pediatrics. 1993;91(3):624–7.

    Article  CAS  Google Scholar 

  21. Younge PA, Kendall JM. Sedation for children requiring wound repair: a randomised controlled double blind comparison of oral midazolam and oral ketamine. Emerg Med J. 2001;18:30–3.

    Article  CAS  Google Scholar 

  22. Everitt IJ, Barnett P. Comparison of two benzodiazepines used for sedation of children undergoing suturing of a laceration in an emergency department. Pediatr Emer Care. 2002;18(2):72–4.

    Article  Google Scholar 

  23. Kogan A, Katz J, Efrat R, et al. Premedication with midazolam in young children: a comparison of four routes of administration. Paediatr Anaesth. 2002;12:685–9.

    Article  Google Scholar 

  24. Frey TM, Florin TA, Caruso M, Zhang N, Zhang Y, Mittiga MR. Effect of intranasal ketamine vs fentanyl on pain reduction for extremity injuries in children: the PRIME randomized clinical trial. JAMA Pediatr. 2019;173(2):140–6.

    Article  Google Scholar 

  25. Poonai N, Canton K, Ali S, et al. Intranasal ketamine for procedural sedation and analgesia in children: a systematic review. PLOS ONE. 2017;12(3).

  26. Xie Z, Shen W, Lin J, Xiao L, Liao M, Gan X. Sedation effects of intranasal dexmedetomidine delivered as sprays versus drops on pediatric response to venous cannulation. Am J Emerg Med. 2017;35:1126–30.

    Article  Google Scholar 

  27. Qiao H, Xie Z, Jia J. Pediatric premedication: a double-blind randomized trial of dexmedetomidine or ketamine alone versus a combination of dexmedetomidine and ketamine. BMC Anaesth. 2017;17:158–65.

    Google Scholar 

  28. Cao Q, Lin Y, Xie Z, et al. Comparison of sedation by intranasal dexmedetomidine and oral chloral hydrate for pediatric ophthalmic examination. Pediatr Anesth. 2017;27(629–36).

  29. Gan X, Lin H, Chen J, Lin Z, Lin Y, Chen W. Rescue sedation with intranasal dexmedetomidine for pediatric ophthalmic examination after chloral hydrate failure: a randomized controlled trial. Clin Ther. 2016;38(6):1522–9.

    Article  CAS  Google Scholar 

  30. Miller J, Xue B, Hossain M, Zhang M-Z, Loepke A, Kurth D. Comparison of dexmedetomidine and chloral hydrate sedation for transthoracic echocardiography in infants and toddlers: a randomized clinical trial. Pediatr Anesth. 2016;26:266–72.

    Article  Google Scholar 

  31. Kundu S, Achar S. Principles of Office Anesthesia: Part II. Topical Anesthesia. Am Fam Phys. 2002;66(1):99–102.

    Google Scholar 

  32. Baxter ALFR, Burke BL, Goldblatt SS, Isaacman DJ, Lawson ML. Local anesthetic and stylet styles: factors associated with resident lumbar puncture success. Pediatrics. 2006;117:876–81.

    Article  Google Scholar 

  33. Friedrichsdorf SJ, Eull D, Weidner C, Postier A. A hospital-wide initiative to eliminate or reduce needle pain in children using lean methodology. Pain Rep. 2018;3:1–11.

    Article  Google Scholar 

  34. Canadian Agency for Drugs and Technologies in Health. Dexmedetomidine for Sedation in the ICU or PICU: A Review of Cost-Effectiveness and Guidelines. Appendix 1. Cost Comparison of ICU Sedatives Ottawa, Ontario, Canada2014. https://www.ncbi.nlm.nih.gov/books/NBK268691/

  35. Mindell JS, Coombs N, Stamatakis E. Measuring physical activity in children and adolescents for dietary surveys: practicalities, problems and pitfalls. Proc Nutr Soc. 2014;73(02):218–25.

    Article  Google Scholar 

  36. Arts SE, Abu-Saad HH, Champion GD, et al. Age-related response to lidocaine-prilocaine (EMLA) emulsion and effect of music distraction on the pain of intravenous cannulation. Pediatrics. 1994;93:797–801.

    Article  CAS  Google Scholar 

Download references

Funding

Department of Paediatrics Resident Research Grant.

Author information

Authors and Affiliations

Authors

Consortia

Corresponding author

Correspondence to Naveen Poonai.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 54 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kumar, K., Ali, S., Sabhaney, V. et al. Anxiolysis for laceration repair in children: a survey of pediatric emergency providers in Canada. Can J Emerg Med 24, 75–83 (2022). https://doi.org/10.1007/s43678-021-00210-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s43678-021-00210-y

Keywords

Navigation