Abstract
Diabetes mellitus is a complex chronic metabolic disease that has a negative impact on patient health as well as creates a significant financial strain on healthcare systems worldwide. An unregulated molecular and cellular wound microenvironment and persistent inflammation are characteristics of chronic diabetic ulcers. Films, antimicrobial dressings, hydrogels, foams, and other biomaterials have all found uses in wound treatment. Despite many studies, there is still no “perfect” therapy for chronic wound healing, and complexities have been addressed. In this paper, we discuss the present difficulties associated with the production of biomaterials for the management and treatment of chronic wounds. Which includes a wide range of important biomaterials and their composites that accelerate angiogenesis, inhibit bacterial infection, collagen matrix deposition, and wound closure. This review also highlights other factors like oxygenation, hormones, obesity, medications, smoking, and nutrition. Finally, the future directions of biomaterials for chronic wound healing are discussed.
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Abbreviations
- CS/PVA:
-
Chitosan/poly vinyl alcohol
- FeONPs:
-
Iron oxide nanoparticles
- CeONPs:
-
Cerium oxide nanoparticles
- AuNPs:
-
Gold nanoparticles
- PHBV:
-
3-Hydroxybutyrate-co-3-hydroxyvalerate
- rGO:
-
Reduced graphene oxide
- ROS:
-
Reactive oxygen species
- PD:
-
Pinus densiflora
- Isab:
-
Isabgol
- SC:
-
Stratum corneum
- SL:
-
Stratum lucidum
- SG:
-
Stratum granulosum
- SS:
-
Stratum spinosum
- SB:
-
Stratum basale
- DM:
-
Diabetes mellitus
- ECM:
-
Extra cellular matrix
- MMPs:
-
Matrix metalloproteinase
- IDDM:
-
Insulin dependent diabetes mellitus
- NIDDM:
-
Noninsulin dependent diabetes mellitus
- VI:
-
Venous insufficiency
- NSAID:
-
Non-steroidal anti-inflammatory drugs
- AIDS:
-
Acquired immunodeficiency syndrome
- ATP:
-
Adenosine triphosphate
- FB:
-
Foreign body
- DHEA:
-
Dehydroepiandrosterone
- HIF-1α/VEGF:
-
Hypoxia-inducible factor 1-alpha/Vascular endothelial growth factor
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The three funding agencies financially support this work. We thankfully acknowledge the Joint CSIR-UGC New Delhi, India (JRF Grants No. 1050/(CSIR-UGC NET JUNE 2019) for Sujit, Council of Scientific and Industrial Research (CSIR), India for JRF grant (JRF Grant No: 09/013(0897)/2019-EMR-I) for Aakriti and Institute of Eminence (IoE), BHU, Varanasi, India for Preeti Suman Saxena.
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PSS, AS, and SY conceived the idea, and SY, AP, and UY formulated manuscript preparation.
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Yadav, S., Prakash, A., Yadav, U. et al. A review on advanced nanoengineered biomaterials for chronic wound healing. Proc.Indian Natl. Sci. Acad. 89, 470–482 (2023). https://doi.org/10.1007/s43538-023-00183-9
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DOI: https://doi.org/10.1007/s43538-023-00183-9