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Engineered Biomaterials for Chronic Wound Healing

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Chronic Wounds, Wound Dressings and Wound Healing

Part of the book series: Recent Clinical Techniques, Results, and Research in Wounds ((RCTRRW,volume 6))

Abstract

Efficient wound healing requires the coordinated integration of associated biological and chemical events in the wound bed. Chronic wounds fail to follow this ordered remodeling cascade, requiring long-term, active intervention usually in the form of high-cost wound dressings. Studies show that no treatment significantly outperforms the others, leading researchers to focus on developing innovative and more efficacious wound healing technologies. This chapter will provide a brief overview of chronic wound healing with a focus on recent engineering approaches that regenerate skin. We discuss various design challenges plaguing chronic wound healing, explore the mechanisms of action for products currently in clinical use, and describe design strategies used in recent developments, such as the use of novel polymers, growth factor release, and cell loading. As healthcare moves toward precision medicine-based strategies, the potential and therapeutic implications of synthetic biomaterials as tunable treatment modalities for chronic wounds will be considered.

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Acknowledgments

The authors acknowledge the research work completed by members of Dr. Gerecht’s laboratory that is cited in this review and the funding resources used to support that work.

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  1. Gemstone Biotherapeutics, Baltimore, MD, USA

    Matthew Davenport & Laura E. Dickinson Ph.D.

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  1. Matthew Davenport
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  2. Laura E. Dickinson Ph.D.
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Correspondence to Laura E. Dickinson Ph.D. .

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  1. Tustin, CA, USA

    Melvin A. Shiffman

  2. Newport Beach, CA, USA

    Mervin Low

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Davenport, M., Dickinson, L.E. (2018). Engineered Biomaterials for Chronic Wound Healing. In: Shiffman, M., Low, M. (eds) Chronic Wounds, Wound Dressings and Wound Healing. Recent Clinical Techniques, Results, and Research in Wounds, vol 6. Springer, Cham. https://doi.org/10.1007/15695_2017_92

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