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Synthesis, Regulatory Factors, and Signaling Pathways of Estrogen in the Ovary

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Abstract

New insights have been thrown for understanding the significant role of estrogen on various systems of humans. Increasing evidences have determined the significant roles of estrogen in female reproductive system. So, the normal synthesis and secretion of estrogen play important roles in maintaining the function of tissues and organs. The ovaries are the main synthetic organs of estrogen. In this review, we summarized the current knowledge of the estrogen synthesis in the ovaries. A series of factors and signaling pathways that regulate the synthesis of estrogen are expounded in detail. Understanding the regulating factors and potential mechanism related to estrogen synthesis will be beneficial for understanding estrogen disorder related diseases and may provide novel therapeutic targets.

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Funding

This study is funded by the National Natural Science Foundation of China, grant number: 81601242 and 81960272.

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Authors and Affiliations

  1. Joint Program of Nanchang University and Queen Mary University of London, School of Medicine, Nanchang University, Nanchang, Jiangxi, People’s Republic of China

    Chuyu Xiao

  2. Department of Cell Biology, College of Medicine, Nanchang University, Nanchang, 330006, Jiangxi Province, People’s Republic of China

    Jing Wang & Chunping Zhang

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  1. Chuyu Xiao
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Chuyu Xiao executed and drafted the manuscript. Jing Wang made critical discussion about the study. Chunping Zhang designed the study. All authors read and approved the final manuscript.

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Correspondence to Chunping Zhang.

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Xiao, C., Wang, J. & Zhang, C. Synthesis, Regulatory Factors, and Signaling Pathways of Estrogen in the Ovary. Reprod. Sci. 30, 350–360 (2023). https://doi.org/10.1007/s43032-022-00932-z

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  • DOI: https://doi.org/10.1007/s43032-022-00932-z

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