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Atosiban and Pregnancy Outcomes Following In Vitro Fertilization Treatment for Infertile Women Requiring One, Two, or More Embryo Transfer Cycles: A Longitudinal Cohort Study

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Abstract

We assessed the effect of atosiban on pregnancy outcomes following in vitro fertilization (IVF) treatment among infertile women requiring different numbers of embryo transfer (ET) cycles (i.e., one, two, and more than two ET cycles). A longitudinal cohort study was conducted by utilizing the data from the Assisted Reproductive Technology Center in a university tertiary hospital during 2007–2017. Patients receiving IVF treatment with at least one ET cycle were included. Pregnancy outcomes following IVF treatment, including biochemical, clinical, and ongoing pregnancies, were investigated. The association between atosiban and IVF pregnancy was assessed using logistic generalized estimating equation models, with adjustment for time-varying clinical characteristics (e.g., maternal age) across multiple ET cycles for an individual. 403 women with 838 ET cycles were included, where 165 patients required one ET cycle, 133 patients required two ET cycles (a total of 266 ET cycles), and 105 patients required more than two ET cycles (a total of 407 ET cycles). Atosiban use was not significantly associated with pregnancy outcomes among all study infertile women undergoing IVF treatment. However, the results for women requiring more than two ET cycles showed significantly increased pregnancy rates associated with atosiban use (i.e., odds ratios [95% confidence interval] of 4.40 [1.52, 12.73] and 2.85 [1.45, 5.60] for clinical and ongoing pregnancies, respectively). This association was not observed for the women requiring only one or two ET cycles. Atosiban is a potential treatment for enhancing IVF pregnancy, especially among infertile women requiring more than two ET cycles.

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Acknowledgments

We gratefully acknowledge the support from National Cheng Kung University Hospital.

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Author notes

  1. Meng-Hsing Wu and Chih-Wei Lin are co-first/equal authorship; these two authors provided equal contribution to this work.

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    Meng-Hsing Wu, Chih-Wei Lin & New Geok Huey

  2. Department of Obstetrics and Gynecology and Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    Meng-Hsing Wu

  3. Department of Statistics, National Cheng Kung University, Tainan, Taiwan

    Pei-Fang Su, Fei-Ci Sie & Yu-Lin Mau

  4. Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    Edward Chai-Cheng Lai & Huang-Tz Ou

  5. School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    Edward Chai-Cheng Lai & Huang-Tz Ou

  6. Department of Pharmacy, National Cheng Kung University Hospital, Tainan, Taiwan

    Edward Chai-Cheng Lai & Huang-Tz Ou

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  1. Meng-Hsing Wu
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  2. Chih-Wei Lin
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Correspondence to Huang-Tz Ou.

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Wu, MH., Lin, CW., Su, PF. et al. Atosiban and Pregnancy Outcomes Following In Vitro Fertilization Treatment for Infertile Women Requiring One, Two, or More Embryo Transfer Cycles: A Longitudinal Cohort Study. Reprod. Sci. 27, 853–859 (2020). https://doi.org/10.1007/s43032-019-00088-3

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  • DOI: https://doi.org/10.1007/s43032-019-00088-3

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