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Multicenter survey of endoscopic treatment of vesicoureteral reflux utilizing polyacrylate-polyalcohol-bulking copolymer (Vantris) in patients with duplex systems

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Abstract

Background

Vesicoureteral reflux (VUR) is an abnormality frequently seen at a complete duplex system (DS). Operational correction is required and completed after the neonatal period when symptoms occur.

Objective

This study aimed to evaluate the efficacy of Vantris and a need for additional surgery in children with DS VUR in a multicenter study.

Patients and methods

We performed retrospective analysis of prospectively acquired data, from 2009 to 2018, on 172 patients with a mean age of 3 years with VUR into either upper or lower moiety of the DS who underwent endoscopic correction utilizing Vantris at five centers worldwide. All patients were with primary VUR. The median follow-up was 7 years.

Results

Reflux was corrected in 122 patients (70%) after the first injection and 35 patients (20%) after the second injection. 15 patients (9%) failed endoscopic correction and required ureteral reimplantation. 13 patients suffered afebrile urinary tract infection, and 9 patients developed febrile urinary tract infection (UTI). 3 patients required partial nephrectomy of the poorly or non-functioning refluxing moiety following the failure of endoscopic correction.

Conclusion

Our data shows that Vantris injection provides a high reflux resolution in a DS with VUR. Successful VUR resolution might spare some patients associated with VUR poorly functioning moieties further surgery.

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Acknowledgements

All senior authors (Tatiana Sklyarova, Ibrahim Ulman, Girolamo Mattioli, Nicola Capozza and Boris Chertin) equally contributed to this study.

Funding

No funding was received to assist with the preparation of this manuscript.

Author information

Authors and Affiliations

  1. Department of Pediatric Urology, Shaare Zedek Medical Center, Faculty of Medical Science, Hebrew University, P.o.B 3235, 91031, Jerusalem, Israel

    Sarit Cohen, Stanislav Kocherov, Jawdat Jaber & Boris Chertin

  2. Pediatric Urology Unit, Bambino Gesù Children’s Hospital, Rome, Italy

    Ermelinda Mele, Michele Innocenzi & Nicola Capozza

  3. Pediatric Surgery, IRCCS Giannina Gaslini, University of Genova, Genova, Italy

    Marcello Carlucci, Michela Wong & Girolamo Mattioli

  4. Pediatric Urology, Ege University, İzmir, Turkey

    Hasan Cayirli, Ali Tekin & Ibrahim Ulman

  5. Russian National Research Medical University, Pediatric Surgery, Children’s Hospital by Filatov, Moscow, Russian Federation

    Sergey Nikolaev, Semen Kovarskiy, Ludmila Menovshchikova & Tatiana Sklyarova

Authors
  1. Sarit Cohen
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  2. Stanislav Kocherov
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  3. Jawdat Jaber
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  4. Ermelinda Mele
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  5. Michele Innocenzi
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  6. Marcello Carlucci
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  7. Michela Wong
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  8. Hasan Cayirli
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  9. Ali Tekin
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  10. Sergey Nikolaev
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  11. Semen Kovarskiy
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  12. Ludmila Menovshchikova
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  13. Tatiana Sklyarova
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  14. Ibrahim Ulman
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  15. Girolamo Mattioli
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  16. Nicola Capozza
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  17. Boris Chertin
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Contributions

All authors contributed to the study conception and design, material preparation, data collection and interpretation, drafting of the manuscript, and critical revision. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Sarit Cohen.

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Conflict of interests

The authors have no conflicts of interest to declare that they are relevant to this article’s content.

Ethics approval

The protocol was approved by the Ethical Committee of all institutions for the entirety of the study period, with necessary reevaluation and renewal to be done bi-annually. The protocol was similar in five departments.

Consent

Informed consent was obtained from legal guardians.

Supplementary Information

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Cohen, S., Kocherov, S., Jaber, J. et al. Multicenter survey of endoscopic treatment of vesicoureteral reflux utilizing polyacrylate-polyalcohol-bulking copolymer (Vantris) in patients with duplex systems. J Ped Endosc Surg 3, 205–209 (2021). https://doi.org/10.1007/s42804-021-00105-w

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  • DOI: https://doi.org/10.1007/s42804-021-00105-w

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