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A Novel L-Cys@Cu MOF Embedding onto Cotton Fiber Surfaces to Exert Excellent Antiviral and Antibacterial Effects

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Abstract

Unpredictable pandemics are likely to pose a significant global threat in the future, and biologically protective textiles will play critical roles in controlling the spread of pathogens during outbreaks. Herein, we present a novel metal–organic framework (MOF) composed of repeating units of a Cu(II)/(L-Cys)2 complex formed through coordination bonds between Cu(II) and L-Cys, while being interconnected by ionic bonds involving Cu(II) and the carboxylate group of L-Cys. After covalently embedding the MOF nanofibers onto cotton fiber surfaces, the resulting fabrics exhibit remarkable virucidal and antibacterial capabilities. Remarkably, even after 200 friction or 50 laundering cycles, the high antiviral ability to inactivate all phi- × 174 within 10 min was maintained, and the bacterial reduction rate against E. coli and S. aureus remained nearly at 100%. The remarkable virucidal effect of the L-Cys@Cu MOF structure is elucidated through a series of α-amylase denaturation simulation tests, providing the first experimental demonstration of the antiviral mechanism, whereby MOF nanofibers induce protein denaturation to inactivate viruses. Moreover, cytotoxicity assessments confirm that the fabrics adorned with MOF nanofibers are safe for human skin. These advantages are promising for the development of protective textiles, highlighting the great potential of nanoscience in combating pandemics.

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The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (Nos. 51873195, 51803186), the Natural Science Foundation of Zhejiang Province (No. LZ22E030004), and Special Support Program for High-Level Talents of Zhejiang Province, Outstanding Talent Project (No. 2021R51003), the National Key Research and Development Program of China (2021YFA1301100, 2021YFA1301101).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China

    Yuanxiang Xiao, Jiajia Fu, Shuangfei Xiang, Shujun Zhao, Feiya Fu & Xiangdong Liu

  2. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, China

    Jingjing Jiang, Rui Cai & Hongyan Diao

  3. Zhejiang Provincial Innovation Center of Advanced Textile Technology, 700 Yuhui Road, Keqiao District, Shaoxing, 312030, China

    Shuangfei Xiang

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  1. Yuanxiang Xiao
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Xiao, Y., Jiang, J., Cai, R. et al. A Novel L-Cys@Cu MOF Embedding onto Cotton Fiber Surfaces to Exert Excellent Antiviral and Antibacterial Effects. Adv. Fiber Mater. 6, 444–457 (2024). https://doi.org/10.1007/s42765-023-00365-6

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