Abstract
Diabetic wounds have become a major clinical problem that cannot be ignored. Gases, such as hydrogen sulphide (H2S), have demonstrated value in inducing angiogenesis and accelerating wound healing, while their effective delivery is still challenging. Here, inspired by the continuous-independent hollow structure of bamboo, we propose novel gasotransmitter microfibres with septal H2S bubbles using microfluidic spinning for diabetic wound healing. Benefitting from the exact control of microfluidics, gasotransmitter microfibres with different bubble sizes and morphologies could be generated successfully and continuously. Under the dual effects of drugs in the shell and gas in the core, the wound healing process could be accelerated. Furthermore, the controllable release of drugs could be achieved by adding responsive materials into the microfiber shell, which would promote continuous effects of contents on demand. Based on in vitro and in vivo studies, we have proven that these gasotransmitter microfibres have a positive impact on inducing angiogenesis and promoting cell proliferation during wound healing. Thus, it is believed that the bamboo-inspired gasotransmitter microfibres will have important value in gasotransmitter research and clinical applications.
Graphical Abstract
The bamboo-inspired microfibres are presented through microfluidics with features of independent chambers for storing and controlled release of hydrogen sulphide (H2S) to the diabetic wound. Even if it is partially damaged, it will not affect the overall gas storage and utilization. Thus, it contributes to improvements in basic research and the transformation of gasotransmitters.
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Data availbility
The data that support the findings of this study are available from the authors, upon reasonable request.
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Acknowledgements
This work was supported by the National Key Research and Development Program of China (2020YFA0908200), the National Science Foundation of China (52073060 and 61927805), National Major New Drug Innovation Science and Technology Major Project (2019ZX09301132), Guangdong Basic and Applied Basic Research Foundation (2021B1515120054, 2019A1515110925), and the Shenzhen Fundamental Research Program (JCYJ20190813152616459 and JCYJ20210324133214038).
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YJZ conceived the study and participated in its design. CZ conducted the experiments, wrote this manuscript and finished all figures in this article. JHG, HZ, YJZ, CHY and LPZ contributed to scientific discussion of the article. YJZ and LPZ helped finish the animal experiments. MN completed the cell experiment in this research.
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Zhao, C., Guo, J., Zhang, H. et al. Bamboo-Inspired Gasotransmitter Microfibres for Wound Healing. Adv. Fiber Mater. 5, 388–399 (2023). https://doi.org/10.1007/s42765-022-00235-7
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DOI: https://doi.org/10.1007/s42765-022-00235-7