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PEGylation of silver nanoparticles via Berginia Ciliata aqueous extract for biological applications

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Abstract

Herein, we have used a non-hazardous and environment-friendly green approach for the PEGylation of silver nanoparticles (PEGylated AgNPs) using an aqueous extract of Berginia Ciliata. The PEGylated AgNPs are also compared with non-PEGylated pristine silver nanoparticles (p-AgNPs) for physicochemical, morphological, and biological properties using multiple characterization techniques and biological assays. The detailed characterization investigation not only confirms the successful capping of PEG but also reveals that PEG highly influences the morphology, yield, and dispersibility of the AgNPs. Such physicochemically altered properties may have also resulted in different biological properties as the PEGylated AgNPs result in higher antioxidant and antileishmanial properties as compared to pristine AgNPs. However, comparatively lower antibacterial and enzyme inhibition potentials are observed for PEGylated AgNPs. Furthermore, in vitro blood compatibility studies reveal the bio-safe nature of both the PEGylated and pristine AgNPs at the tested concentrations. Our study thus concludes that the green synthesis approach could be successfully utilized for PEGylation of metallic NPs of pharmacological importance.

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  1. Bilal Qadeer and Muhammad Aslam Khan contributed equally to this work.

Authors and Affiliations

  1. Department of Biological Sciences, Faculty of Science, International Islamic University (IIU), Islamabad, Pakistan

    Bilal Qadeer, Muhammad Aslam Khan, Hamza Tariq, Muhammad Usman Zahid, Uzair Ahmad & Syed Ali Imran Bokhari

  2. King Abdullah International Medical Research Centre (KAIMRC), King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia

    Bilal Qadeer, Hanan Abdul Aziz Alismail & Syed Jawad Hussain

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  1. Bilal Qadeer
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Contributions

B.Q carried out the experimental work, analysed the data, and wrote the manuscript. M.A.K. perceived the idea, wrote and reviewed the manuscript. H.T, M.U.Z, H.A.A, S.J.H and U.A., assisted in the experimental work, resources, data and characterization analysis. S.A.I.B supervised the project. The authors B.Q and M.A.K contributed equally to this work.

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Qadeer, B., Khan, M.A., Tariq, H. et al. PEGylation of silver nanoparticles via Berginia Ciliata aqueous extract for biological applications. emergent mater. (2024). https://doi.org/10.1007/s42247-024-00727-9

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