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Hydrogel advancements in vascular tissue regeneration: a comprehensive review and future prospects

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Abstract

Vascular tissue regeneration has gained a lot of interest, especially in addressing the challenges associated with vascular-related diseases and injuries. Hydrogels have shown great promise in the field of vascular tissue regeneration because of their special features, which include biocompatibility and mechanical characteristics that may be adjusted, as well as their likeness to the natural extracellular matrix. The fabrication techniques for vascular scaffolds have been the subject of much investigation due to the effectiveness of scaffold-based tissue engineering in producing new blood vessel tissues. The creation of vascular scaffolds has been greatly aided by recent developments in 3D printing, which presents an encouraging concept for the vascularization of tissues. This review covers the various cutting-edge hydrogel formulations, fabrication techniques, and strategies for the development of functional and biocompatible vascular scaffolds. The review also reveals these novel hydrogel-based techniques’ possible uses, difficulties, and possibilities for the future of vascular tissue regeneration.

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Funding

The authors would like to thank the Science, Technology, and Innovation Funding Authority (STDF), Egypt (FLUG Call 1—Project ID 46715) for funding a research project relevant to this review topic.

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Authors and Affiliations

  1. Nanomedicine Research Laboratories, Center for Materials Sciences (CMS), Zewail City of Science and Technology, 6Th of October City, Giza, 12478, Egypt

    Hend A. Elshabrawy, Hagar A. Moustafa & Ibrahim M. El-Sherbiny

  2. Harefield Heart Science Centre, National Heart and Lung Institute, Imperial College, London, UK

    Magdi H. Yacoub

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  1. Hend A. Elshabrawy
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  2. Hagar A. Moustafa
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  4. Ibrahim M. El-Sherbiny
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Contributions

HAE: literature survey, writing original draft; HAM: literature survey, writing original draft; MHY: writing—review and editing; IME: conceptualization; supervision; writing—review and editing.

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Correspondence to Ibrahim M. El-Sherbiny.

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Ibrahim M. El-Sherbiny.

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Elshabrawy, H.A., Moustafa, H.A., Yacoub, M.H. et al. Hydrogel advancements in vascular tissue regeneration: a comprehensive review and future prospects. emergent mater. (2024). https://doi.org/10.1007/s42247-024-00678-1

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