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Susceptibility-weighted MR imaging in the diagnosis of superficial siderosis of the central nervous system: what can it add to conventional MR imaging and diffusion-weighted MR imaging

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Chinese Journal of Academic Radiology Aims and scope Submit manuscript

Abstract

Objectives

To systematically investigate the capability of susceptibility-weighted imaging (SWI) in the assessment of SS by comparisons with conventional MRI and DWI.

Methods

From retrospective data, 21 patients with SS who underwent conventional MRI, DWI and SWI sequences were selected. The number of microbleeds in the brain parenchyma and extent of the lesions identified between the three techniques were compared using one-factor analysis of variance.

Results

Susceptibility-weighted imaging showed excellent intra- and interobserver agreements in the assessment of SS, and also detected a larger number of SS with wider distribution in the surface of the brain and more cerebral microbleeds in brain parenchyma compared to the conventional MR sequences and DWI sequence (all p < 0.05).

Conclusion

Susceptibility-weighted imaging can provide excellent intra- and interobserver agreements and sensitive imaging biomarkers for detecting the presence of SS, especially the microbleeds in brain parenchyma, thus having the potential to improve early detection and progression monitoring of this disease.

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Acknowledgements

The authors thank Prof. Lin for his kind proof-reading.

Funding

This work was supported by the Grant of Youth Research Project of Fujian Province Health and Family Planning Scientific Research Talent Training Project (Grant number: Fujian Health Science and Education Letter [2017] 411; contract number: 2017-1-46).

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Author notes

  1. Yuanlin Yu and Zebin Xiao contributed equally to this study.

Authors and Affiliations

  1. Department of Radiology, First Affiliated Hospital of Fujian Medical University, 20 Cha-Zhong Road, Fuzhou, 350005, Fujian, China

    Yuanlin Yu, Zebin Xiao, Xiuzhu Huang, Yingyan Zheng & Dariong Cao

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  1. Yuanlin Yu
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  2. Zebin Xiao
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  3. Xiuzhu Huang
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Correspondence to Dariong Cao.

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Yu, Y., Xiao, Z., Huang, X. et al. Susceptibility-weighted MR imaging in the diagnosis of superficial siderosis of the central nervous system: what can it add to conventional MR imaging and diffusion-weighted MR imaging. Chin J Acad Radiol 2, 63–69 (2020). https://doi.org/10.1007/s42058-020-00022-6

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  • DOI: https://doi.org/10.1007/s42058-020-00022-6

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