Abstract
Enhancement, the improvement of mental capacities with psychoactive substances and technologies has stimulated one of the largest debates in contemporary bioethics. Surprisingly few participants in this debate take note of the tendentious legal status of psychoactive pharmaceuticals as the primary means of enhancement.
Enhancement technologies and substances have measurable effects on specific measurable cognitive functions. A major issue of contention in the debate is how to evaluate these effects, i. e. which theory of value to use. It is contested whether the pleasures and achievements resulting from the use of enhancement can be counted as such or can be ignored or devaluate by calling them fraudulent or inauthentic.
The alleged and real benefits of enhancement are not expected to be evenly distributed, nor is it always clear whether enhancement is a zero-sum game or has benefits even for the non-users. This results in a complex structure of risks and benefits for individuals and groups, which needs to be broken down in detail.
Similar content being viewed by others
Notes
The terminological choice ‘enhancement’ itself is not unproblematic. It carries a strong positive connotation, which might not be justified by every intervention which falls under the extension of the term. Labelling the use of psychoactive pharmaceuticals and technologies enhancement in the professional debate might even reinforce public perception that the interventions in question are good for their users on the whole, and might thus lead to reduced critical stance in prospective user’s deliberation (Mohamed 2014, 540). Alternative terms such as ‘human engineering’ have, however, not caught on in the debate.
Under ‘neuroenhancement’ we subsume means of enhancement, which modify cognitive and emotive functions by means of modifying neural activity, either chemically or electromagnetically. The term thus covers a major part of the enhancement toolbox currently under debate, such as smart drugs, moral enhancement, mood enhancement, love enhancement etc. Enhancement technologies probably not within this spectrum are means of increasing longevity and physical enhancements such as most doping in sports.
Earlier research into the effects of drugs beyond therapeutic, preventative and palliative use was conducted in the 1950s and early 1960s but discontinued and widely forgotten for political reasons. For an impressive overview of the earlier research see (Grinspoon and Bakalar 1979).
‘Neuroscience’ in this case is an umbrella term for a number of disciplines contributing to a new understanding of psychoactive substances. For example, molecular neuroscience and neuropharmacology provided key insights into the mechanisms of action of the substances in question, e. g. neurotransmitter antagonists or reuptake inhibitors. Cognitive psychology provided a detailed taxonomy of cognitive and emotive functions, neuroanatomy generated increasingly detailed atlases of brain regions and their interconnections and cognitive neuroscience could – on this basis – identify neural networks involved in the realisation of functions. Thus the neuroscientific evidence referred to spans a broad spectrum of methods, including behavioural, microscopic, and imaging techniques applied over different scales, ranging from nanometre scale of molecular processes to the meter scale of bodily behaviour.
The Deipnosophistai are a report of fictitious debates held during three banquets allegedly visited by the author. The guests to the banquets include several famous philosophers and politicians and some fictional individuals. The whole writing has become famous because it includes quotations of over 700 classic authors, many of which would otherwise not have been passed down to us.
The 1925 convention was comparably permissive as it only limited international trade and some types of distribution within the signatory counties. For this reason, the United States of America never signed this treaty. Their more extreme prohibitionist policy was welded into international law with the Convention for Limiting the Manufacture and Regulating the Distribution of Narcotic Drugs of 1931.
In part inspired by some of the results generated with psychedelic drugs in the 1950s.
The most abstract version of such an objective list axiology most likely is the pair: (change in survival (in years), change in welfare). More detailed measures of medical benefit are often tailored to a specific group of patients. There are for example different methods to measure cognitive function in patients with anxiety syndrome, patients with dementia and patients with depression (Ragguett et al. 2016).
There is a significant number of deontological and virtue ethicist contributions as well. These will be separate topics in the remainder of this little article series.
The terminology for different positions is not unproblematic either. Not only does it refer to political positions, which are, at least in this constellation specific to the political system of the United States of America and not representative of other national, much less of international contexts. Even in the American context it subsumes position under the wrong label. Not every bioconservative for example is a political conservative. That is why several authors (Caplan 2009; Macklin 2006) suggested alternative nomenclatures, which, however, have not caught on yet.
References
Ach, Johann S., Birgit Beck, Beate Lüttenberg und Barbara Stroop. 2018. “Neuro-Enhancement: Worum es geht.” In Die Leistungssteigerung des menschlichen Gehirns: Neuro-Enhancement im interdisziplinären Diskurs, edited by Nicola Erny, Matthias Herrgen und Jan C. Schmidt. 37-56. Wiesbaden: Springer Fachmedien Wiesbaden.
Agar, Nicholas. 2010. Humanity’s End: Why We Should Reject Radical Enhancement. A Bradford Book.
Alesina, Alberto und Eliana La Ferrara. 2000. “Participation in Heterogeneous Communities.” The Quarterly Journal of Economics 115 (3): 847-904.
Allhoff, Fritz. 2005. “Germ-line Genetic Enhancement and Rawlsian Primary Goods.” Kennedy Institute of Ethics journal 15 (1): 39-56.
Allhoff, Fritz, Patrick Lin, James Moor und John Weckert. 2010. Ethics of Human Enhancement: 25 Questions & Answers. In Studies in Ethics, Law, and Technology.
Allhoff, Fritz, Patrick Lin und Jesse Steinberg. 2011. “Ethics of Human Enhancement: An Executive Summary.” Science and Engineering Ethics 17 (2): 201-212.
Aristotle. 1984. Complete works of Aristotle. The revised oxford translation. Herausgegeben von Jonathan Barnes. Princeton, N.J: Princeton University Press.
Athenaeus. 2006. The Learned Banqueters: Books I‑III.106e, edited by S. Douglas Olson. London: Harvard University Press.
Barbrook, Richard und Andy Cameron. 1996. The Californian Ideology.
Baudelaire, Charles. 2002. On Wine and Hashish. Herausgegeben von M. Drabble. Potsdam: Hesperus.
Beck, Birgit. 2015. “Conceptual and Practical Problems of Moral Enhancement.” Bioethics 29 (4): 233-240.
Boldt, Joachim und Giovanni Maio. 2009. “Neuroenhancement. Vom technizistischen Missverständnis geistiger Leistungsfähigkeit.” In Das technisierte Gehirn : Neurotechnologien als Herausforderung für Ethik und Anthropologie, edited by Oliver Müller, Jens Clausen und Giovanni Maio. 383-397. Paderborn: mentis.
Bostrom, Nick. 2005. “Transhumanist Values.” Journal of Philosophical Research 30 (Supplement): 3‑14.
Bostrom, Nick. 2008. “Why I Want to be a Posthuman When I Grow Up.” In Medical enhancement and posthumanity, edited by Bert Gordijn und Ruth Chadwick. 107-137. Dordrecht: Springer.
Buchanan, Allan. 2008. “Enhancement and the ethics of development.” Kennedy Institute of Ethics journal 18 (1): 1‑34.
Buchanan, Allan. 2009. “Moral Status and Human Enhancement.” Philosophy & Public Affairs 37 (4): 346-381.
Buchanan, Allen. 2011. Better than human. The promise and perils of enhancing ourselves. New York: Oxford University Press.
Buchanan, Allen, Dan. W. Brock, Norman Daniels und Daniel Wikler. 2001. From Chance to Choice. Genetics and Justice. Cambridge / New York: Cambridge University Press.
Caplan, Arthur L. 2009. “Good, better or best.” In Human Enhancement, edited by Julian Savulescu und Nick Bostrom. 199--209. Oxford / New York: Oxford University Press.
Carhart-Harris, Robin. 2018. “The entropic brain - revisited.” Neuropharmacology (in press).
Carhart-Harris, Robin, Robert Leech, Peter Hellyer, Murray Shanahan, Amanda Feilding, Enzo Tagliazucchi, Dante Chialvo und David Nutt. 2014. “The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs.” Frontiers in Human Neuroscience 8 (20). https://doi.org/10.3389/fnhum.2014.00020
Carter, Adrian, Emily Bell, Eric Racine und Wayne Hall. 2011. “Ethical Issues Raised by Proposals to Treat Addiction Using Deep Brain Stimulation.” Neuroethics 4 (2): 129-142.
Chatterjee, Anjan. 2004. “Cosmetic Neurology - The Controversy over Enhancing Movement, Mentation, and Mood.” Neurology 63 (6): 968-974.
Choi, Jung-Kyoo und Samuel Bowles. 2007. “The Coevolution of Parochial Altruism and War.” Science 318 (5850): 636-640.
Cicero, Marcus Tullius. 1988. Staatstheoretische Schriften. Herausgegeben von Konrad Ziegler. Berlin: Akademie Verlag.
Coenen, C. 2014. “Transhumanism and its genesis: the shaping of human enhancement discourse by vision of the future.” Humana.Mente Journal of Philosophical Studies 26: 35-58.
Daniels, Norman und James Sabin. 1997. “Limits to Health Care: Fair Procedures, Democratic Deliberation, and the Legitimacy Problem for Insurers.” Philosophy & Public Affairs 26 (4): 303-350.
de Jongh, Reinoud 2017. “Overclocking the brain? The potential and limitations of cognition-enhancing drugs.” In Rethinking cognitive enhancement, edited by R. H. J. ter Meulen, Ahmed Dahir Mohamed und Wayne Hall. 37-56. Oxford: Oxford University Press.
DeGrazia, David. 2000. “Prozac, Enhancement, and Self‐Creation.” Hastings Center Report 30 (2): 34-40.
DeGrazia, David. 2005. Human Identity and Bioethics. Cambridge / New York: Cambridge University Press.
Douglas, Thomas. 2015. “The Harms of Enhancement and the Conclusive Reasons View.” Cambridge Quarterly of Healthcare Ethics 24 (1): 23-36.
Earleywine, Mitch. 2002. Understanding Marijuana: A New Look at the Scientific Evidence. Oxford / New York: Oxford University Press.
Elliott, Carl. 1998. “The Tyranny of Happiness: Ethics and Cosmetic Psychopharmacology.” In Enhancing Human Traits. Ethical and Social Implications, edited by Erik Parens. 177-188. Washington D.C.: Norton.
Elliott, Carl. 2003. Better Than Well: American Medicine Meets the American Dream. New Yorl / London: W.W. Norton & Company.
Farah, Martha J., Judy Illes, Robert Cook-Deegan, Howard Gardner, Eric Kandel, Patricia King, Eric Parens, Barbara Sahakian und Paul Root Wolpe. 2004. “Neurocognitive enhancement: what can we do and what should we do?” Nature Reviews Neuroscience 5: 421.
Fingarette, Herbert. 1988. Heavy Drinking: The Myth of Alcoholism as a Disease. Berkeley / Los Angeles / London: University of California Press.
Fukuyama, Francis. 2002. Our Posthuman Future: Consequences of the Biotechnology Revolution. New York: Farrar Straus & Giroux.
Glover, Jonathan. 2007. Choosing Children. Genes, Disability, and Design. Oxford / New York: Oxford University Press.
Grinspoon, Lester und J.B. Bakalar. 1979. Psychedelic Drugs Reconsidered. New York: Basic Books.
Habermas, Jürgen. 2002. Die Zukunft der menschlichen Natur. Auf dem Weg zu einer liberalen Eugenik? Frankfurt am Main: Suhrkamp.
Harris, John. 1992. Wonderwoman and Superman. The Ethics of Human Biotechnology. Oxford / New York: Oxford University Press.
Harris, John. 2007. Enhancing Evolution: The Ethical Case for Making Better People. Princeton: Princeton University Press.
Heinz, Andreas und Sabine Müller. 2017. “Exaggerating the benefits and downplaying the risks in the bioethical debate on cognitive neuroenhancement.” In Rethinking cognitive enhancement, edited by R. H. J. ter Meulen, Ahmed Dahir Mohamed und Wayne Hall. 69-86. Oxford: Oxfort University Press.
Horvath, Jared C., Olivia Carter und Jason D. Forte. 2014. “Transcranial Direct Current Stimulation: Five Important Issues We Aren’t Discussing (But Probably Should Be).” Frontiers in systems neuroscience 8. https://doi.org/10.3389/fnsys.2014.00002
Hughes, James. 2004. Citizen Cyborg. Why democratic societies must respond to the redesigned human of the future. Cambridge, MA: Westview Press.
Ilieva, I., J. Boland und M. J. Farah. 2013. “Objective and subjective cognitive enhancing effects of mixed amphetamine salts in healthy people.” Neuropharmacology 64: 496-505.
Kamieński, Ł. 2016. Shooting Up: A Short History of Drugs and War. Oxford / New York: Oxford University Press.
Kamm, Frances. 2009. “What is and is not wrong with enhancement?” In Human Enhancement, edited by Julian Savulescu und Nick Bostrom. 91-130. Oxford / New York: Oxford University Press.
Kass, L. R. 2003. “Ageless bodies, happy souls: biotechnology and the pursuit of perfection.” New Atlantis (1): 9–28. https://www.thenewatlantis.com/publications/ageless-bodies-happy-souls
Kramer, Peter D. 1994. Listening to Prozac. London: Fourth Estate.
Kurzweil, Ray. 1990. The age of intelligent machines. Cambridge, Mass.: MIT Press.
Lenk, Christian. 2002. Therapie und Enhancement: Ziele und Grenzen der modernen Medizin. Münster: Lit.
Lewis, Marc. 2017. “Addiction and the Brain: Development, Not Disease.” Neuroethics 10 (1): 7‑18.
Lieb, K. 2010. Hirndoping: warum wir nicht alles schlucken solllten. München: Artemis & Winkler.
Macklin, Ruth. 2006. “The New Conservatives in Bioethics: Who Are They and What Do They Seek?” The Hastings Center Report 36 (1): 34-43.
Mehlman, Maxwell J. 2003. Wondergenes: Genetic Enhancement and the Future of Society. Bloomington, In. / Indianapolis, In.: Indiana University Press.
Mehlman, Maxwell J. und Jeffrey R. Botkin. 1998. Access to the genome. The challenge to equality. Washington, D.C.: Georgetown University Press.
Mehlman, Maxwell J., Patrick Lin und Keith Abney. 2013. Enhanced Warfighters: Risk, Ethics, and Policy. SSRN. https://doi.org/10.2139/ssrn.2202982
Mill, John Stuart. 1977. On liberty. Herausgegeben von J. M. Robson. Toronto / London: University of Toronto Press / Routledge & Kegan Paul.
Mill, John Stewart. 2006. Utilitarismus. Hamburg: Meiner.
Moesgen, Diana und Miachael Klein. 2015. Neuroenhancement. Stuttgart: Kohlhammer Verlag.
Mohamed, Ahmed Dahir. 2014. “Neuroethical issues in pharmacological cognitive enhancement.” Wiley Interdisciplinary Reviews: Cognitive Science 5 (5): 533-549.
Müller, Christian P. und Gunter Schumann. 2011. “Drugs as Instruments: A New Framework for Non-Addictive Psychoactive Drug Use.” Behavioral and Brain Sciences 34 (6): 293-310.
Nutt, David. 2012. Drugs Without the Hot Air. Cambridge: UIT Cambridge.
Parens, Eric. 1998. “Is Better Always Good?: The Enhancement Project.” Hastings Center Report 28 (1): 1‑17.
Parens, Eric. 2005. “Authenticity and Ambivalence” Hastings Center Report 35 (5): 34-41.
Persson, Ingmar und Julian Savulescu. 2012. Unfit for the Future. the Need for Moral Enhancement. Oxford / New York: Oxford University Press.
Pollan, Michael. 2018. How to change your mind. New York: Penguin Press.
Powell, Russell und Allen Buchanan. 2011. “Breaking Evolution’s Chains: The Prospect of Deliberate Genetic Modification in Humans.” The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine 36 (1): 6‑27.
President’s Council On Bioethics (U.S.). 2003. Beyond Therapy: Biotechnology and the Pursuit of Happiness. Washington, D.C: The President’s Council on Bioethics.
Ragguett, Renee-Marie, Danielle S Cha, Ron Kakar, Joshua D Rosenblat, Yena Lee und Roger S McIntyre. 2016. “Assessing and measuring cognitive function in major depressive disorder.” Evidence Based Mental Health 19 (4): 106-109.
Repantis, Dimitris, Oona Laisney und Isabella Heuser. 2010. “Acetylcholinesterase inhibitors and memantine for neuroenhancement in healthy individuals: A systematic review.” Pharmacological Research 61 (6): 473-481.
Repantis, Dimitris, Peter Schlattmann, Oona Laisney und Isabella Heuser. 2009. “Antidepressants for neuroenhancement in healthy individuals: a systematic review.” Poiesis & Praxis 6 (3): 139-174.
Repantis, Dimitris, Peter Schlattmann, Oona Laisney und Isabella Heuser. 2010. “Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review.” Pharmacological Research 62 (3): 187-206.
Sandberg, Anders. 2011. “Cognitive Enhancement: Upgrading the Brain.” In Enhancing Human Capacities, edited by Julian Savulescu, Ruud ter Muelen und Guy Kahane. 71-91. Malden, Ma / Oxford: Wiley-Blackwell.
Sandberg, Anders und Joao Fabiano. 2017. “Modeling the Social Dynamics of Moral Enhancement: Social Strategies Sold Over the Counter and the Stability of Society.” Cambridge Quarterly of Healthcare Ethics 26 (3): 431-445.
Sandel, Michael J. 2009. The Case Against Perfection. Cambridge, Mass. / London: Harvard University Press.
Savulescu, Julian. 2001. “Procreative beneficence: why we should select the best children.” Bioethics 15 (5-6): 413-26.
Schleim, Stephan. 2010. “Cognitive Enhancement - Sechs Gründe dagegen.” In Künstliche Sinne, gedoptes Gehirn: Neurotechnik und Neuroethik, edited by H. Fink und R. Rosenzweig. 179-207. Paderborn: Mentis.
Schleim, Stephan, Knut Schnell und Henrik Walter. 2007. “Perspectives on Psychopharmalogical Enhancement.” Newsletter of the EA European Academy of Technology and Innovation Assessment, 1‑3.
Selgelid, Michael J. 2014. “Moderate eugenics and human enhancement.” Medicine, Health Care and Philosophy 17 (1): 3‑12.
Silver, Lee M. 1997. Remaking Eden. How Genetic Engineering and Cloning Will Transform the American Family. New York: Avon Books.
Singh, Ilina und Kelly J. Kelleher. 2010. “Neuroenhancement in Young People: Proposal for Research, Policy, and Clinical Management.” AJOB Neuroscience 1 (1): 3‑16.
Smith, M. E. und M. J. Farah. 2011. “Are prescription stimulants “smart pills”? The epidemiology and cognitive neuroscience of prescription stimulant use by normal healthy individuals.” Psychol Bull 137 (5): 717-41.
Stelmack, Robert M. und Anastasios Stalikas. 1991. “Galen and the Humour Theory of Temperament.” Personality and Individual Differences 12 (3): 255-263.
Sterling, Bruce. 1996. Schismatrix plus. New York: Ace Books.
Wasserman, David. 2014. “When bad people do good things. Will moral enhancement make the world a better place?” Journal of Medical Ethics 40 (6): 374-375.
Wasson, R. Gordon, Albert Hofmann und Carl A. P. Ruck. 2008. The Road to Eleusis: Unveiling the Secret of the Mysteries. Berkeley, Cal.: North Atlantic Books.
Wikler, Daniel. 1979. “Paternalism and the Mildly Retarded.” Philosophy & Public Affairs 8 (4): 377-392.
Wikler, Daniel. 2010. “Paternalism in the Age of Cognitive Enhancement: Do Civil Liberties Presuppose Roughly Equal Mental Ability?” In Human Enhancement, edited by Julian Savulescu und Nick Bostrom. Oxford, New York: Oxford University Press.
Wilson, James. 2007. “Transhumanism and moral equality.” Bioethics 21 (8): 419-25.
Yudkowsky, Eliezer. 2008. “Artificial Intelligence as a Positive and Negative Factor in Global Risk.” In Global Catastrophic Risks, edited by Nick Bostrom und Milan M. Cirkovic. 309-345. Oxford / New York: Oxford University Press.
Acknowledgements
We want to thank our colleagues at the Institute for Ethics in the Neurosciences at Forschungszentrum Jülich, who provided ample and helpful input in several debates. A special thanks goes to Markus Rüther, who will co-author one part of this little series and significantly helped to shape the whole.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Heinrichs, JH., Stake, M. Enhancement: Consequentialist Arguments. ZEMO 1, 321–342 (2018). https://doi.org/10.1007/s42048-018-0025-9
Published:
Issue Date:
DOI: https://doi.org/10.1007/s42048-018-0025-9