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Numerical Studies on Magnetic Driven Targeted Drug Delivery in Human Vasculature

  • Review Article
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Journal of the Indian Institute of Science Aims and scope

Abstract

Magnetic driven targeted drug delivery (TDD) involves the manipulation of magnetic drug carriers, such as nano/micro particles or bubbles, within the body using external magnetic fields to precisely reach the intended target location. This method is utilized in treating severe illnesses like cancerous tumors and nervous disorders, offering higher efficacy with reduced drug dosages and side effects. While numerous studies have simulated magnetic driven TDD, comprehensive reviews remain scarce. This article presents an extensive review of computational/numerical work done on magnetic driven TDD utilizing both microbubbles and non-bubbles (nano/micro particles) within human vasculature and lung airways. The study aims to analyze the drug delivery problem from physical and numerical perspectives. Key highlights include artery wall models (rigid, flexible, or porous), models of force acting on particles, relevant governing equations, discussions on parameters of interest and their effects on drug delivery efficacy. Finally, the article briefly outlines common trends observed in magnetic driven TDD problems and their underlying physical principles.

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Notes

  1. Magnetic number: A non-dimensional number that is proportional to magnetic field strength.

  2. CE is the fraction of the number of particles that get captured in the region of interest with respect to the total number of injected particles.

  3. Targeting efficiency is defined as the fraction of the inlet particles that got captured in the target region with respect to the number of particles released at the inlet.

  4. A drug elimination parameter represents an irrevocable body mechanism that removes administered drugs from it.

  5. The MFF comprised a combination of positive and negative pulsed magnetic fields generated by electromagnetic coils. The purpose of the MFF was to prevent nanoparticles from adhering to the vessel walls during magnetic guidance.

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  1. Department of Mechanical Engineering, Indian Institute of Technology Bombay, Mumbai, India

    Nikhil Kumar Tamboli & Janani Srree Murallidharan

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Tamboli, N.K., Murallidharan, J.S. Numerical Studies on Magnetic Driven Targeted Drug Delivery in Human Vasculature. J Indian Inst Sci (2024). https://doi.org/10.1007/s41745-024-00428-6

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