Abstract
Optical polarimetry has increased interest in probing finer details of soft tissue components representing alterations during pathological tissue transformation. Stromal collagen, a potential candidate for optical polarimetry, plays a vital role during the developmental stages of cancer. This review presents an overview of the biology and optical response of stromal collagen followed by instrumentation and image analysis in various optical polarimetry configurations that help extract the relevant features for efficient tissue classification for diagnostic applications. Part 1 deals with the linear optical polarization properties of collagen, while Part 2 probes the extraction of finer structural details of collagen with the help of nonlinear optical polarimetry. Both in vivo and extracted tissue measurements are discussed, and directions for future research are recommended.
Similar content being viewed by others
References
Ahmad I, Ahmad M, Khan K, Ashraf S, Ahmad S, Ikram M (2015) Ex vivo characterization of normal and adenocarcinoma colon samples by Mueller matrix polarimetry. J Biomed Opt 20:056012. https://doi.org/10.1117/1.JBO.20.5.056012
Ahmad I, Khaliq A, Iqbal M, Khan S (2020) Mueller matrix polarimetry for characterization of skin tissue samples: a review. Photodiagnosis Photodyn Ther 30:101708. https://doi.org/10.1016/j.pdpdt.2020.101708
Alali S, Vitkin A (2015) Polarized light imaging in biomedicine: emerging Mueller matrix methodologies for bulk tissue assessment. J Biomed Opt 20(6):061104. https://doi.org/10.1117/1.jbo.20.6.061104
Anastasiadou M, De Martino A, Clement D, Liège F, Laude-Boulesteix B, Quang N, Dreyfuss J, Huynh B, Nazac A, Schwartz L, Cohen H (2008) Polarimetric imaging for the diagnosis of cervical cancer. Phys Status Solidi Curr Top Solid State Phys 5:1423–1426. https://doi.org/10.1002/pssc.200777805
Antonelli M-R, Pierangelo A, Novikova T, Validire P, Benali A, Gayet B, De Martino A (2010) Mueller matrix imaging of human colon tissue for cancer diagnostics: how Monte Carlo modeling can help in the interpretation of experimental data. Opt Express 18:10200. https://doi.org/10.1364/oe.18.010200
Arifler D, Pavlova I, Gillenwater A, Richards-kortum R (2007) Light scattering from collagen fiber networks: micro-optical properties of normal and neoplastic stroma. Biophysic 92:3260–3274. https://doi.org/10.1529/biophysj.106.089839
Azzam RMA (1982) Light polarization: a rich source of information. Opt Acta 29:685–689
Borovkova M, Peyvasteh M, Dubolazov O, Ushenko Y, Ushenko V, Bykov A, Deby S, Rehbinder J, Novikova T, Meglinski I (2018) Complementary analysis of Mueller-matrix images of optically anisotropic highly scattering biological tissues. J Eur Opt Soc-Rapid Publ. https://doi.org/10.1186/s41476-018-0085-9
Brett EA, Sauter MA, Machens H-G, Duscher D (2020) Tumor-associated collagen signatures: pushing tumor boundaries. Cancer Metab 8:1–5. https://doi.org/10.1186/s40170-020-00221-w
Buckley C, Fabert M, Kinet D, Kucikas V, Pagnoux D (2020) Design of an endomicroscope including a resonant fiber-based microprobe dedicated to endoscopic polarimetric imaging for medical diagnosis. Biomed Opt Express 11:7032–7052. https://doi.org/10.1364/BOE.403157
Burla F, Dussi S, Martinez-Torres C, Tauber J, van der Gucht J, Koenderink GH (2020) Connectivity and plasticity determine collagen network fracture. Proc Nal Acad Sci 117(15):8326–8334. https://doi.org/10.1073/pnas.1920062117
Cavaco ACM, Dâmaso S, Casimiro S, Costa L (2020) Collagen biology making inroads into prognosis and treatment of cancer progression and metastasis. Cancer Metastasis Rev 39(3):603–623. https://doi.org/10.1007/s10555-020-09888-5
Chang J, He H, He C (2019) DoFP polarimeter based polarization microscope for biomedical applications. Proc SPIE Dyn Fluctuat Biomed Photon XIII 9707:97070W
Chang Y, Gao W (2021) Mueller matrix polarization parameter tomographic imaging method in the backscattering configuration. Opt Lasers Eng 146:106692. https://doi.org/10.1016/j.optlaseng.2021.106692
Chen D, Zeng N, Wang Y, He H, Tuchin VV, Ma H (2016) Study of optical clearing in polarization measurements by Monte Carlo simulations with anisotropic tissue-mimicking models. J Biomed Opt 21:081209. https://doi.org/10.1117/1.jbo.21.8.081209
Chen B, Li W, He H, He C, Guo J, Shen Y, Liu S, Sun T, Wu J, Ma H (2021) Analysis and calibration of linear birefringence orientation parameters derived from Mueller matrix for multi-layered tissues. Opt Lasers Eng 146:106690. https://doi.org/10.1016/j.optlaseng.2021.106690
Chipman RA (1994) Polarimetry. Handbook of optics, 2nd edn. Mc-Graw-Hill, New York, pp 1–37
Chue-Sang J, Bai Y, Stoff S, Straton D, Ramaswamy S, Ramella-Roman JC (2016) Use of combined polarization-sensitive optical coherence tomography and Mueller matrix imaging for the polarimetric characterization of excised biological tissue. J Biomed Opt 21:071109. https://doi.org/10.1117/1.jbo.21.7.071109
Chue-Sang J, Bai Y, Stoff S, Gonzalez M, Holness N, Gomes J, Jung R, Gandjbakhche A, Chernomordik VV, Ramella-Roman JC (2017) Use of Mueller matrix polarimetry and optical coherence tomography in the characterization of cervical collagen anisotropy. J Biomed Opt 22:1. https://doi.org/10.1117/1.jbo.22.8.086010
Cicchi R, Vogler N, Kapsokalyvas D, Dietzek B, Popp J, Pavone FS (2013) From molecular structure to tissue architecture: collagen organization probed by SHG microscopy. J Biophotonics 6:129–142. https://doi.org/10.1002/jbio.201200092
Compain E, Drevillon B (1999) General and self-consistent method for the calibration of polarization modulators, polarimeters, and Mueller-matrix ellipsometers. Appl Opt 38(16):3490–3502. https://doi.org/10.1364/ao.38.003490
Conklin MW, Eickhoff JC, Riching KM, Pehlke CA, Eliceiri KW, Provenzano PP, Friedl A, Keely PJ (2011) Aligned collagen is a prognostic signature for survival in human breast carcinoma. Am J Pathol 178:1221–1232. https://doi.org/10.1016/j.ajpath.2010.11.076
David H (1988) Rudolf virchow and modern aspects of tumor pathology. Pathol Res Pract 183:356–364. https://doi.org/10.1016/S0344-0338(88)80138-9
Desroches J, Pagnoux D, Louradour F, Barthélémy A (2009) Fiber-optic device for endoscopic polarization imaging. Opt Lett 34:3409–3411. https://doi.org/10.1364/OL.34.003409
Dong Y, Qi J, He H, He C, Liu S, Wu J, Elson DS, Ma H (2017) Quantitatively characterizing the microstructural features of breast ductal carcinoma tissues in different progression stages by Mueller matrix microscope. Biomed Opt Express 8:3643–3655. https://doi.org/10.1364/BOE.8.003643
Dong Y, Liu S, Shen Y, He H, Ma H (2020) Probing variations of fibrous structures during the development of breast ductal carcinoma tissues via Mueller matrix imaging. Biomed Opt Express 11:4960. https://doi.org/10.1364/boe.397441
Dong Y, Wan J, Si L, Meng Y, Dong Y, Liu S, He H (2021) Deriving polarimetry feature parameters to characterize microstructural features in histological sections of breast tissues. IEEE Trans Biomed Eng. 68(3):881–892. https://doi.org/10.1109/TBME.2020.3019755
Du E, He H, Zeng N, Sun M, Guo Y, Wu J, Liu S, Ma H (2014) Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues. J Biomed Opt 19:076013. https://doi.org/10.1117/1.jbo.19.7.076013
Fang M, Yuan J, Peng C, Li Y (2014) Collagen as a double-edged sword in tumor progression. Tumor Biol 35(4):2871–2882. https://doi.org/10.1007/s13277-013-1511-7
Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Piñeros M, Znaor A, Bray F (2021) Cancer statistics for the year 2020: an overview. Int J Cancer 149:778–789. https://doi.org/10.1002/ijc.33588
Forward S, Gribble A, Alali S, Lindenmaier AA, Vitkin IA (2017) Flexible polarimetric probe for 3 × 3 Mueller matrix measurements of biological tissue. Sci Rep. https://doi.org/10.1038/s41598-017-12099-8
Garcia AM, Magalhes FL, Soares JS, Junior EP, Lima MFRD, Mamede M, Paula AMD (2018) Second harmonic generation imaging of the collagen architecture in prostate cancer tissue. Biomed Phys Eng Express. https://doi.org/10.1088/2057-1976/aaa379
Georgakoudi I, Müller MG, Boone CW, Dasari RR, Feld MS, Jacobson BC, Carr-Locke DL, Van Dam J, Sheets EE, Crum CP, Badizadegan K (2002) NAD(P)H and collagen as in vivo quantitative fluorescent biomarkers of epithelial precancerous changes. Cancer Res 62:682–687
Ghosh N, Vitkin IA (2011) Tissue polarimetry: concepts, challenges, applications, and outlook. J Biomed Opt 16:110801. https://doi.org/10.1117/1.3652896
Gil JJ (2016b) Invariant quantities of a Mueller matrix under rotation and retarder transformations. J Opt Soc Am A 33:52. https://doi.org/10.1364/josaa.33.000052
Gil JJ (2016a) On optimal filtering of measured Mueller matrices. Appl Opt 55:5449. https://doi.org/10.1364/ao.55.005449
Gil JJ, Bernabeu E (2017) Depolarization and polarization indices of an optical system. Optica Acta: Int J Optics 33:185–189. https://doi.org/10.1080/713821924
Givens CR, Kostinski AB (1993) A simple necessary and sufficient condition on physically realizable Mueller matrices. J Mod Opt 40:471–481. https://doi.org/10.1080/09500349314550471
Golaraei A, Kontenis L, Cisek R, Tokarz D, Done SJ, Wilson BC, Barzda V (2016) Changes of collagen ultrastructure in breast cancer tissue determined by second-harmonic generation double Stokes-Mueller polarimetric microscopy. Biomed Opt Express 7:4054–4068. https://doi.org/10.1364/BOE.7.004054
Goldstein DH (1992) Mueller matrix dual-rotating retarder polarimeter. Appl Opt 31:6676. https://doi.org/10.1364/ao.31.006676
Gribble A, Pinkert MA, Westreich J, Liu Y, Keikhosravi A, Khorasani M, Nofech-Mozes S, Eliceiri KW, Vitkin A (2019) A multiscale Mueller polarimetry module for a stereo zoom microscope. Biomed Eng Lett 9:339–349. https://doi.org/10.1007/s13534-019-00116-w
Gurrala R, Byrne CE, Brown LM, Tiongco RFP, Matossian MD, Savoie JJ, Collins-Burow BM, Burow ME, Martin EC, Lau FH (2021) Quantifying breast cancer-driven fiber alignment and collagen deposition in primary human breast tissue. Front Bioeng Biotechnol 9:63. https://doi.org/10.3389/fbioe.2021.618448
Heinrich C, Rehbinder J, Nazac A, Teig B, Pierangelo A, Zallat J (2018) Mueller polarimetric imaging of biological tissues: classification in a decision-theoretic framework. J Opt Soc Am A 35:2046. https://doi.org/10.1364/josaa.35.002046
He H, Sun M, Zeng N, Du E, Guo Y, He Y, Ma H (2014) Mapping local anisotropy axis for scattering media using backscattering Mueller matrix imaging. Proc SPIE Biomed Appl Light Scatter VIII 8952:89521B. https://doi.org/10.1117/12.2038979
He C, He H, Chang J, Dong Y, Liu S, Zeng N, He Y, Ma H (2015) Characterizing microstructures of cancerous tissues using multispectral transformed Mueller matrix polarization parameters. Biomed Opt Express 6:2934–2945. https://doi.org/10.1364/BOE.6.002934
He H, Chang J, He C, Ma H (2016) Transformation of full 4 × 4 Mueller matrices: a quantitative technique for biomedical diagnosis. Proc Dyn Fluctuat Biomed Photon XIII 9707:97070K. https://doi.org/10.1117/12.2210878
He H, Zeng N, Du E (2018) Mapping local orientation of aligned fibrous scatterers for cancerous tissues using backscattering Mueller matrix imaging. J Biomed Opt 19:106007. https://doi.org/10.1117/1.JBO.19.10.106007
He C, Chang J, Hu Q, Wang J, Antonello J, He H, Liu S, Lin J, Dai B, Elson DS, Xi P, Ma H, Booth MJ (2019b) Complex vectorial optics through gradient index lens cascades. Nat Commun. https://doi.org/10.1038/s41467-019-12286-3
He H, Liao R, Zeng N, Li P, Chen Z, Liu X, Ma H (2019a) Mueller matrix polarimetry-An emerging new tool for characterizing the microstructural feature of complex biological specimen. J Light Technol 37:2534–2548. https://doi.org/10.1109/JLT.2018.2868845
Huang R, Shen Y, He H, Ma H (2021) Comparative study of influence of imaging resolution on Mueller matrix. Dyn Fluctuat Biomed Photon XVIII 11641:116410A
Hu H, Garcia-Caurel E, Anna G, Goudail F (2014) Simplified calibration procedure for Mueller polarimeter in transmission configuration. Opt Lett 39:418. https://doi.org/10.1364/ol.39.000418
Ivanov D, Dremin V, Borisova E, Bykov A, Novikova T, Meglinski I, Ossikovski R (2021) Polarization and depolarization metrics as optical markers in support to histopathology of ex vivo colon tissue. Biomed Opt Express 12:4560–4572
Jacques SL, Lee K (1998) Polarized video imaging of skin. Proc Lasers Surg Adv Charact Therap Syst VIII. 3245:1–7. https://doi.org/10.1117/12.312307
Jacques SL, Roman JR, Lee K (2000) Imaging superficial tissues with polarized light. Lasers Surg Med 26:119–129
Jagtap J, Chandel S, Das N, Soni J, Chatterjee S, Pradhan A, Ghosh N (2014) Quantitative Mueller matrix fluorescence spectroscopy for precancer detection. Opt Lett 39:243. https://doi.org/10.1364/ol.39.000243
Jansen KA, Licup AJ, Sharma A, Rens R, MacKintosh FC, Koenderink GH (2018) The role of network architecture in collagen mechanics. Biophys J 114:2665–2678. https://doi.org/10.1016/j.bpj.2018.04.043
Kalwani NM, Ong CA, Lysaght AC, Haward SJ, McKinley GH, Stankovic KM (2013) Quantitative polarized light microscopy of unstained mammalian cochlear sections. J Biomed Opt 18:026021. https://doi.org/10.1117/1.jbo.18.2.026021
Keikhosravi A, Bredfeldt JS, Sagar AK, Eliceiri KW (2014) Second-harmonic generation imaging of cancer. In: Waters JC, Wittman T (eds) Methods in cell biology. Academic Press, pp 531–546
Keikhosravi A, Liu Y, Drifka C, Woo KM, Verma A, Oldenbourg R, Eliceiri KW (2017) Quantification of collagen organization in histopathology samples using liquid crystal based polarization microscopy. Biomed Opt Express 8:4243. https://doi.org/10.1364/boe.8.004243
Komai Y, Ushiki T (1991) The three-dimensional organization of collagen fibrils in the human cornea and sclera. Invest Ophthalmol Vis Sci 32(8):2244–58
Kupinski M, Boffety M, Goudail F, Ossikovski R, Pierangelo A, Rehbinder J, Vizet J, Novikova T (2019) Polarimetric information for pre-cancer detection from uterine cervix specimens. Opt InfoBase Conf Pap Part F 168:5691–5702. https://doi.org/10.1364/BODA.2019.JT4A.47
Laude-Boulesteix B, De Martino A, Drévillon B, Schwartz L (2004) Mueller polarimetric imaging system with liquid crystals. Appl Opt 43:2824–2832. https://doi.org/10.1364/AO.43.002824
Lee HR, Li P, Yoo TSH, Lotz C, Groeber-Becker FK, Dembski S, Garcia-Caurel E, Ossikovski R, Ma H, Novikova T (2019) Digital histology with Mueller microscopy: how to mitigate an impact of tissue cut thickness fluctuations. J Biomed Opt 24:1. https://doi.org/10.1117/1.jbo.24.7.076004
Lee HR, Saytashev I, Du Le VN, Mahendroo M, Ramella-Roman J, Novikova T (2021) Mueller matrix imaging for collagen scoring in mice model of pregnancy. Sci Rep. https://doi.org/10.1038/s41598-021-95020-8
Le Gratiet A, Dubreuil M, Rivet S, Le Grand Y (2016) Scanning Mueller polarimetric microscopy. Opt Lett 41:4336. https://doi.org/10.1364/ol.41.004336
Le GA, Lanzano L, Bendandi A, Marongiu R, Bianchini P, Sheppard CJR, Diaspro A (2021) Phasor approach of Mueller matrix optical scanning microscopy for biological tissue imaging. Biophys J 120(15):3112–3125. https://doi.org/10.1016/j.bpj.2021.06.008
Liu T, Sun T, He H, Liu S, Yang D, Wu J, Ma H (2018) Comparative study of the imaging contrasts of Mueller matrix derived parameters between transmission and backscattering polarimetry. Biomed Opt Express 9:4054–4068. https://doi.org/10.1364/BOE.9.004413
Liu B, Yao Y, Liu R, Ma H, Ma L (2019) Mueller polarimetric imaging for characterizing the collagen microstructures of breast cancer tissues in different genotypes. Opt Commun 433:60–67. https://doi.org/10.1016/j.optcom.2018.09.037
Liu Y, Dong Y, Si L, Meng R, Dong Y, Ma H (2021) Comparison between image texture and polarization features in histopathology. Biomed Opt Express 12:1593–1608. https://doi.org/10.1364/BOE.416382
Li P, Lv D, He H, Ma H (2018) Separating azimuthal orientation dependence in polarization measurements of anisotropic media. Opt Express 26:3791. https://doi.org/10.1364/oe.26.003791
Li W, Narice BF, Anumba DO, Matcher SJ (2019) Polarization-sensitive optical coherence tomography with a conical beam scan for the investigation of birefringence and collagen alignment in the human cervix. Biomed Opt Express 10:4190. https://doi.org/10.1364/boe.10.004190
Qi J, Elson DS, Stoyanov D (2019) Eigenvalue calibration method for 3 × 3 Mueller polarimeters. Opt Lett 44(9):2362–2365. https://doi.org/10.1364/OL.44.002362
Lu S-Y, Chipman RA (1996) Interpretation of Mueller matrices based on polar decomposition. J Opt Soc Am A 13:1106–1113
Manhas S, Vizet J, Deby S, Vanel J-C, Boito P, Verdier M, De MA, Pagnoux D (2015) Demonstration of full 4 × 4 Mueller polarimetry through an optical fiber for endoscopic applications. Opt Express 23:3047–3054. https://doi.org/10.1364/OE.23.003047
Mazumder N, Qiu J, Kao FJ, Diaspro A (2017) Mueller matrix signature in advanced fluorescence microscopy imaging. J Opt 19:025301. https://doi.org/10.1088/2040-8986/aa5114
Ma H, He H, Dong Y, Liu T (2018) Quantitative detection of breast ductal carcinoma tissues at different progression stages using Mueller matrix microscope. Proc SPIE Dyn Fluctuat Biomed Photon XV 10493:104930O. https://doi.org/10.1117/12.2288696
Meglinski I, Trifonyuk L, Bachinsky V, Vanchulyak O, Bodnar B, Sidor M, Dubolazov O, Ushenko A, Ushenko Y, Soltys IV, Bykov A, Hogan B, Novikova T (2021) Shedding the polarized light on biological tissues. Springer
Montejo KA, Chue-Sang J, Bai Y, Stoff S, Holness N, Gonzalez M, Gomes J, Gandjbakhche A, Chernomordik VV, Ramella-Roman JC (2017) Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy. Diagnosis Treat Dis Breast Reprod Syst 10043:1004303. https://doi.org/10.1117/1.JBO.23.12.121605
Mozumder M, Jagtap J, Shukla P, Pradhan A (2013) Images of depolarization power and retardance to study stages of dysplasia in human cervical tissues. Proc SPIE, Biomed Appl Light Scatter V 7907:1–11
Mukherjee S (2010) The emperor of all Maladies. Scribner, New York
Nazac A, Bancelin S, Teig B, Haj Ibrahim B, Fernandez H, Schanne-Klein MC, De Martino A (2015) Optimization of Picrosirius red staining protocol to determine collagen fiber orientations in vaginal and uterine cervical tissues by Mueller polarized microscopy. Microsc Res Tech 78:723–730. https://doi.org/10.1002/jemt.22530
Novikova T, Pierangelo A, Manhas S, Benali A, Validire P, Gayet B, De Martino A (2013) The origins of polarimetric image contrast between healthy and cancerous human colon tissue. Appl Phys Lett. https://doi.org/10.1063/1.4811414
Novikova T, Rehbinder J, Deby S, Haddad H, Vizet J, Pierangelo A, Validire P, Benali A, Gayet B, Teig B, Nazac A, Drévillon B, Moreau F, De MA (2016) Multi-spectral mueller matrix imaging polarimetry for studies of human tissues. Opt InfoBase Conf Pap 2016:4–6. https://doi.org/10.1364/TRANSLATIONAL.2016.TTh3B.2
Oldenbourg R, Mei G (1995) New polarized light microscope with precision universal compensator. J Microsc 180:140–147. https://doi.org/10.1111/j.1365-2818.1995.tb03669.x
Ortega-Quijano N, Arce-Diego JL (2011) Mueller matrix differential decomposition. Opt Lett 36:1942. https://doi.org/10.1364/ol.36.001942
Ossikovski R (2009) Analysis of depolarizing Mueller matrices through a symmetric decomposition. J Opt Soc Am A 26:1109. https://doi.org/10.1364/josaa.26.001109
Ossikovski R, Devlaminck V (2014) General criterion for the physical realizability of the differential Mueller matrix. Opt Lett 39:1216–1219. https://doi.org/10.1364/OL.39.001216
Ossikovski R, Al Bugami B, Garcia-Caurel E, Cloude SR (2020) Polarizer calibration method for Mueller matrix polarimeters. Appl Opt 59:10389. https://doi.org/10.1364/ao.409799
Ouellette JN, Drifka CR, Pointer KB, Liu Y, Lieberthal TJ, Kao WJ, Kuo JS, Loeffler AG, Eliceiri KW (2021) Navigating the collagen jungle: the biomedical potential of fiber organization in cancer. Bioengineering 8:1–19. https://doi.org/10.3390/bioengineering8020017
Owczarzy A, Kurasiński R, Kulig K, Rogóż W, Szkudlarek A, Maciążek-Jurczyk M (2020) Collagen–structure, properties and application. Eng Biomater 156:17–23. https://doi.org/10.34821/eng.biomat.156.2020.17-23
Park J, Lindberg A, Vizet J, Gennet C, Park J, Lindberg A, Vizet J, Rehbinder J, Gennet C, Vanel J, Nazac A, Debras E, Capmas P (2019) Cervical cancer diagnostics with a multispectral Mueller polarimetric colposcope. Proc SPIE Clin Preclin Opt Diagn 11073:110730A. https://doi.org/10.1117/12.2526934
Peyvasteh M, Tryfonyuk L, Ushenko V, Syvokorovskaya AV, Dubolazov A, Vanchulyak O, Ushenko A, Ushenko Y, Gorsky M, Sidor M, Tomka Y, Soltys I, Bykov A, Meglinski I (2020) 3D Mueller-matrix-based azimuthal invariant tomography of polycrystalline structure within benign and malignant soft-tissue tumours. Laser Phys Lett. https://doi.org/10.1088/1612-202X/abbee0
Pham T, Lo Y (2018) Extraction of effective parameters of anisotropic optical materials using a decoupled analytical method materials using a decoupled analytical method. J Biomed Opt 17(2):025006. https://doi.org/10.1117/1.JBO.17.2.025006
Pham T, Lo Y, Pham T, Lo Y (2018) Extraction of effective parameters of turbid media utilizing the Mueller matrix approach:study of glucose sensing. J Biomed Opt 17(9):97002–97011. https://doi.org/10.1117/1.JBO.17.9.097002
Pierangelo A, Benali A, Antonelli M, Novikova T (2011) Ex-vivo characterization of human colon cancer by Mueller polarimetric imaging. Opt Express 19(2):1582–1593. https://doi.org/10.1364/OE.19.001582
Pierangelo A, Manhas S, Benali A, Fallet C, Antonelli M-R, Novikova T, Gayet B, Validire P, De MA (2012) Ex vivo photometric and polarimetric multilayer characterization of human healthy colon by multispectral Mueller imaging. J Biomed Opt 17(6):066009. https://doi.org/10.1117/1.JBO.17.6
Pierangelo A, Nazac A, Benali A, Validire P, Cohen H, Novikova T, Ibrahim BH, Manhas S, Fallet C, Antonelli M-R, Martino A-D (2013a) Polarimetric imaging of uterine cervix: a case study. Opt Express 21:14120. https://doi.org/10.1364/oe.21.014120
Pierangelo A, Manhas S, Benali A, Fallet C, Totobenazara J-L, Antonelli M-R, Novikova T, Gayet B, De Martino A, Validire P (2013b) Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas. J Biomed Opt 18:046014. https://doi.org/10.1117/1.jbo.18.4.046014
Pijanka JK, Coudrillier B, Ziegler K, Sorensen T, Meek KM, Nguyen TD, Quigley HA, Boote C (2012) Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae. Invest Ophthalmol vis Sci 53:5258–5270. https://doi.org/10.1167/IOVS.12-9705
Pradhan A, Zaffar M (2018) Application of wavelet based MFDFA on Mueller matrix images for cervical pre-cancer detection. Proc Opt Biopsy XVI Toward Real-Time Spectrosc Imag Diagn 10489:1048916. https://doi.org/10.1117/12.2289965
Provenzano PP, Eliceiri KW, Campbell JM, Inman DR, White JG, Keely PJ (2006) Collagen reorganization at the tumor-stromal interface facilitates local invasion. BMC Med 4:1–15. https://doi.org/10.1186/1741-7015-4-38
Purwar H, Soni J, Lakhotia H, Chandel S, Banerjee C, Ghosh N (2012) Development and eigenvalue calibration of an automated spectral Mueller matrix system for biomedical polarimetry. Proc SPIE Biomed Appl Light Scatter VI 8230:823019
Qi J, He H, Lin J, Dong Y, Chen D, Ma H, Elson DS (2018) Assessment of tissue polarimetric properties using Stokes polarimetric imaging with circularly polarized illumination. J Biophoton 11:e201700139. https://doi.org/10.1002/jbio.201700139
Qi J, Elson DS (2016) A high definition Mueller polarimetric endoscope for tissue characterisation. Sci Rep 6:1–11. https://doi.org/10.1038/srep25953
Qi J, Elson DS (2017) Mueller polarimetric imaging for surgical and diagnostic applications: a review. J Biophotonics 10:950–982. https://doi.org/10.1002/jbio.201600152
Qu Y, Ren W, Liu S, Liu P, Xie L, Zhang X, Zhang S, Chang S, Xu R (2016) Polarized hyperspectral imaging system for in vivo detection of vulvar lichen sclerosis. Opt Diagn Sens XVI Toward Point-of-Care Diagn 9715:97150Q. https://doi.org/10.1117/12.2213802
Qu Y, Smith ZJ, Tyler K, Chang S, Shen S, Sun M, Xu RX (2021) Applying limiting entropy to quantify the alignment of collagen fibers by polarized light imaging. Math Biosci Eng 18:2331–2356. https://doi.org/10.3934/MBE.2021118
Ramella-Roman JC, Gonzalez M, Chue-Sang J, Montejo K, Krup K, Srinivas V, DeHoog E, Madhivanan P (2018) Development and characterization of a snapshot Mueller matrix polarimeter for the determination of cervical cancer risk in the low resource setting. Optics Biophoton Low-Resour Settings IV. https://doi.org/10.1117/12.2290592
Ramella-Roman JC, Saytashev I, Piccini M (2020) A review of polarization-based imaging technologies for clinical and preclinical applications. J Opt 22:123001. https://doi.org/10.1088/2040-8986/abbf8a
Rehbinder J, Deby S, Haddad H, Teig B, Nazac A, Pierangelo A, Moreau F (2015) Diagnosis of uterine cervix cancer using Müller polarimetry a comparison with histopathology. Proc SPIE-OSA Novel Biophoton Tech Appl III 9540:95400W. https://doi.org/10.1364/ECBO.2015.95400W
Rehbinder J, Haddad H, Deby S, Teig B, Nazac A, Novikova T, Pierangelo A, Moreau F (2016) Ex vivo Mueller polarimetric imaging of the uterine cervix: a first statistical evaluation. J Biomed Opt 21:1–8. https://doi.org/10.1117/1.JBO.21.7.071113
Rivet S, Dubreuil M, Bradu A, Le GY (2019) Fast spectrally encoded Mueller optical scanning microscopy. Sci Rep. https://doi.org/10.1038/s41598-019-40467-z
Roa C, Du Le VN, Mahendroo M, Saytashev I, Ramella-Roman JC (2021) Auto-detection of cervical collagen and elastin in Mueller matrix polarimetry microscopic images using K-NN and semantic segmentation classification. Biomed Opt Express 12:2236. https://doi.org/10.1364/boe.420079
Saytashev I, Saha S, Chue-Sang J, Lopez P, Laughrey M, Ramella-Roman JC (2020) Self validating Mueller matrix Micro-Mesoscope (SAMMM) for the characterization of biological media. Opt Lett 45:2168. https://doi.org/10.1364/ol.387747
Schucht P, Lee HR, Mezouar HM, Hewer E, Raabe A, Murek M, Zubak I, Goldberg J, Kövari E, Pierangelo A, Novikova T (2020) Visualization of white matter fiber tracts of brain tissue sections with wide-field imaging mueller polarimetry. IEEE Trans Med Imag 39:4376–4382. https://doi.org/10.1109/TMI.2020.3018439
Sharma M, Balasubramanian S, Sundaram S, Narayanan Unni S (2020) Polarimetric evaluation of bulk samples and unstained sections of colon tissue. In: Frontiers in Optics/Laser Science. OSA Technical Digest (Optical Society of America, 2020), p JTu1B.15. https://doi.org/10.1364/FIO.2020.JTu1B.15
Sharma M, Narayanan S, Balasubramanian S, Sundaram S, Krishnamurthy P, Hegde A (2021) Histopathological correlations of bulk tissue polarimetric images: case study. J Biophotonics 14:1–12. https://doi.org/10.1002/jbio.202000475
Sheng W, Li W, Qi J, Liu T, He H, Dong Y, Liu S, Wu J, Elson DS, Ma H (2019) Quantitative analysis of 4 × 4 mueller matrix transformation parameters for biomedical imaging. Photonics 6:1–14. https://doi.org/10.3390/PHOTONICS6010034
Shen Y, Sheng W, He H, Li W, Ma H (2020) Assessing distribution features of fibrous structures using Mueller matrix derived parameters: a quantitative method for breast carcinoma tissues detection and staging. Proc SPIE Dyn Fluctuat Biomed Photon 11239:112390F. https://doi.org/10.1117/12.2545512
Shukla P, Pradhan A (2009) Mueller decomposition images for cervical tissue: potential for discriminating normal and dysplastic states. Opt Express 17:1600. https://doi.org/10.1364/oe.17.001600
Soni J, Chandel S, Jagtap J, Pradhan A, Ghosh N (2013a) Mueller matrix polarimetry in fluorescence scattering from biological tissues. Opt InfoBase Conf Pap. https://doi.org/10.1364/fio.2013.fw5a.3
Soni J, Purwar H, Lakhotia H, Chandel S, Banerjee C, Kumar U, Ghosh N (2013b) Quantitative fluorescence and elastic scattering tissue polarimetry using an Eigenvalue calibrated spectroscopic Mueller matrix system. Opt Express 21:15475. https://doi.org/10.1364/oe.21.015475
Spandana KU, Mahato KK, Mazumder N (2019) Polarization-resolved Stokes-Mueller imaging: a review of technology and applications. Lasers Med Sci 34:1283–1293. https://doi.org/10.1007/s10103-019-02752-1
Stoff S, Chue-sang J, Holness NA, Gandjbakhche A (2016) Cervical collagen imaging for determining preterm labor risks using a colposcope with full mueller matrix capability. SPIE BiOS 9689:1–5. https://doi.org/10.1117/12.2213387
Stylianou A, Voutouri C, Mpekris F, Stylianopoulos T (2021) Pancreatic cancer collagen-based optical signatures. Proc Polar Light Optical Angular Moment Biomed Diagn 11646:1164613. https://doi.org/10.1117/12.2582590
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209–249. https://doi.org/10.3322/caac.21660
Sun M, He H, Zeng N, Du E, Guo Y, Peng C, He Y, Ma H (2014) Probing microstructural information of anisotropic scattering media using rotation-independent polarization parameters. Appl Opt 53:2949. https://doi.org/10.1364/ao.53.002949
Trifonyuk L, Baranowski W, Ushenko V, Olar O, Dubolazov A, Ushenko Y, Bodnar B, Vanchulyak O, Kushnerik L, Sakhnovskiy M (2018) 2D-Mueller-matrix tomography of optically anisotropic polycrystalline networks of biological tissues histological sections. Opto-Electron Rev 26:252–259. https://doi.org/10.1016/j.opelre.2018.07.001
Tuchin VV, Valeriĭ V, Wang LV, Zimnyakov DA (2006) Optical polarization in biomedical applications. Springer, Berlin
Ushenko YA (2015) Laser autofluorescence polarimetry of optically anisotropic structures of biological tissues in cancer diagnostics. Opt Spectrosc 118:1040–1049. https://doi.org/10.1134/S0030400X15060235
Ushenko YA, Sidor MI, Pashkovskaia N, Koval GD, Marchuk YF, Andreichuk D (2014) Laser polarization-variable autofluorescence of the network of optically anisotropic biological tissues: diagnostics and differentiation of early stages of cancer of cervix uteri. J Innov Opt Health Sci 7:1–10. https://doi.org/10.1142/S1793545814500242
Vizet J, Manhas S, Deby S, Vanel J, Martino A De, Pagnoux D (2014) Demonstration of Mueller polarimetry through an optical fiber for endoscopic applications. In: CLEO: 2014, OSA Technical Digest (Optical Society of America, 2014), paper JW2A.31. https://doi.org/10.1364/CLEO_AT.2014.JW2A.31
Vizet J, Manhas S, Tran J, Validire P, Benali A, Garcia-Caurel E, Pierangelo A, De MA, Pagnoux D (2016) Optical fiber-based full Mueller polarimeter for endoscopic imaging using a two-wavelength simultaneous measurement method. J Biomed Opt 21:071106. https://doi.org/10.1117/1.jbo.21.7.071106
Vizet J, Rehbinder J, Deby S, Roussel S, Nazac A, Genestie C, Haie-meder C, Fernandez H, Moreau F, Pierangelo A (2017) In vivo imaging of uterine cervix with a Mueller polarimetric colposcope. Sci Rep 7(2471):1–12. https://doi.org/10.1038/s41598-017-02645-9
Wang W, Lim LG, Srivastava S, Yan JSB, Shabbir A, Liu Q (2014) Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples. J Biomed Opt 19:046020. https://doi.org/10.1117/1.jbo.19.4.046020
Wang Y, He H, Chang J, Zeng N, Liu S, Li M (2015) Differentiating characteristic microstructural features of cancerous tissues using Mueller matrix microscope. Micron 79:8–15. https://doi.org/10.1016/j.micron.2015.07.014
Wang Y, He H, Chang J, He C, Liu S, Li M, Zeng N, Wu J, Ma H (2016a) Mueller matrix microscope: a quantitative tool to facilitate detections and fibrosis scorings of liver cirrhosis and cancer tissues. J Biomed Opt 21:071112. https://doi.org/10.1117/1.jbo.21.7.071112
Wang W, Lim LG, Srivastava S, So JB, Shabbir A, Liu Q (2016b) Investigation on the potential of Mueller matrix imaging for digital staining. J Biophotonics 9:364–375. https://doi.org/10.1002/jbio.201500006
Wang J, Zheng W, Lin K, Huang Z (2016c) Integrated Mueller-matrix near-infrared imaging and point-wise spectroscopy improves colonic cancer detection. Biomed Opt Express 7:1116–1126. https://doi.org/10.1364/BOE.7.001116
Wang Y, Wang J, Meng J, Shi Z, Wang R, Zhang X (2019) Detection of non-small cell lung cancer cells based on microfluidic polarization microscopic image analysis. Electrophoresis 40:1202–1211. https://doi.org/10.1002/elps.201800284
Wen B, Campbell KR, Tilbury K, Nadiarnykh O, Brewer MA, Patankar M, Singh V, Eliceiri KW, Campagnola PJ (2016) 3D texture analysis for classification of second harmonic generation images of human ovarian cancer. Sci Rep 6:1–9. https://doi.org/10.1038/srep35734
Westreich J, Khorasani M, Jones B, Demidov V, Nofech-Mozes S, Vitkin A (2019) Novel methodology to image stromal tissue and assess its morphological features with polarized light: towards a tumour microenvironment prognostic signature. Biomed Opt Express 10:3963. https://doi.org/10.1364/boe.10.003963
Wolman M (1975) Polarized light microscopy as a tool of diagnostic pathology: a review. J Histochem Cytochem 23:21–50. https://doi.org/10.1177/23.1.1090645
Xie Q, Zeng CN, Chen CD, Tuchin VV (2019) Differentiating tissue clearing process using distinct optical clearing agents by Mueller matrix microscope. Biomed Opt Express 10:3269–3280. https://doi.org/10.1364/BOE.10.003269
Zaffar M, Pradhan A (2020a) Assessment of anisotropy of collagen structures through spatial frequencies of Mueller matrix images for cervical pre-cancer detection. Appl Opt 59:1237. https://doi.org/10.1364/ao.377105
Zaffar M, Pradhan A (2020) Mapping of retardance, diattenuation and polarizance vector on Poincare sphere for diagnosis and classification of cervical precancer. J Biophoton 13(4):e201960139. https://doi.org/10.1002/jbio.201960139
Zaffar M, Sahoo GR, Pradhan A (2020) Different orders of scattering through time-resolved Mueller matrix imaging estimates of pre-malignancy in human cervical tissues. Appl Opt 59:4286–4295. https://doi.org/10.1364/AO.389786
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Sharma, M., Shaji, C. & Narayanan Unni, S. Optical polarization response of collagen: role in clinical cancer diagnostics—part I. ISSS J Micro Smart Syst 11, 3–30 (2022). https://doi.org/10.1007/s41683-022-00090-z
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s41683-022-00090-z