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State of the art in medical applications using non-thermal atmospheric pressure plasma

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Abstract

Plasma medical science is a novel interdisciplinary field that combines studies on plasma science and medical science, with the anticipation that understanding the scientific principles governing plasma medical science will lead to innovations in the field. Non-thermal atmospheric pressure plasma has been used for medical treatments, such as for cancer, blood coagulation, and wound healing. The interactions that occur between plasma and cells/tissues have been analyzed extensively. Direct and indirect treatment of cells with plasma has broadened the applications of non-thermal atmospheric pressure plasma in medicine. Examples of indirect treatment include plasma-assisted immune-therapy and plasma-activated medium. Controlling intracellular redox balance may be key in plasma cancer treatment. Animal studies are required to test the effectiveness and safety of these treatments for future clinical applications.

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(Adapted from Akihiro Kono’s lecture notes)

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From (Schutze et al. 1998)

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From Akihiro Kono’s lecture note

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Abbreviations

ALK:

Anaplastic lymphoma kinase

AMD:

Age-related macular degeneration

APF:

Aminophenyl Fluorescein

CNV:

Choroidal neovascularization

DAPI:

4′,6-diamidino-2-phenylindole

DBD:

Dielectric barrier discharge

DNA:

deoxyribonucleic acid

DSB:

Double-strand break

EGFR:

Epidermal growth factor receptor

ERK:

Extracellular signal-regulated kinase

ESR:

Electron spin resonance

FACS:

Fluoresence-activated cell sorting

GFP:

Green fluorescent protein

H2DCFDA:

2′,7′-dichlorodihydrofluorescein diacetate

HNE:

4-Hydroxy-2-nonenal (HNE)

HPF:

Hydroxyphenyl Fluorescein

ICD:

Immunogenic cell death

iPS:

induced pluripotent stem cells

LDH:

Lactate dehydrogenase

LIF:

Laser-induced fluorescence

MAPK:

Mitogen-activated protein kinase

mRNA:

Messenger RNA

mTOR:

Mammalian target of rapamycin

mTORC1:

mTOR complex 1

mTORC2:

mTOR complex 2

MTS:

5-(3-carboxymethoxyphenyl)-2-(4,5-dimenthylthiazoly)-3-(4-sulfophenyl)tetrazo-lium, inner salt

NAC:

N-acetyl cysteine

NEAPP:

Non equilibrium atmospheric pressure plasma

NHDFs:

Normal human dermal fibroblasts

OES:

Optical emission spectroscopy

PAL:

Plasma-activated Ringer’s lactate solution

PAM:

PAM

PARP:

Poly (ADP-ribose) polymerase

PCR:

Polymerase chain reaction

PD-L1:

Programmed death ligand 1

PI:

Propidium iodide

PI3K:

Phosphatidylinositol-4,5-bisphosphate 3-kinase

PIP2:

Phosphatidylinositol 4,5-bisphosphate

PIP3:

Phosphatidylinositol (3,4,5) trisphosphates

PTEN:

Phosphatase and tensin homolog

RAS:

Rat sarcoma

ROS:

Reactive oxygen species

RNA:

Ribonucleic acid

RNS:

Reactive nitrogen species

ROS:

Reactive oxygen species

RT-PCR:

Real-time polymerase chain reaction

SEM:

Scanning electron microscope

SDS:

Sodium dodecyl sulfate

SDS-PAGE:

SDS polyacrylamide gel electrophoresis

SOD:

Superoxide dismutase

TBARS:

Thiobarbituric acid reactive substances

TALIF:

Two-photon absorption laser-induced fluorescence

TP53:

Tumor suppressor protein p53

TUNEL:

Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling

VEGFR:

Vascular endothelial growth factor receptor

VUVAS:

Vacuum ultraviolet absorption spectroscopy

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Acknowledgements

This work was partly supported by Grants-in-Aid for Scientific Research on Innovative Areas “Plasma Medical Innovation” (Grant Nos. 24108002 and 24108008), a Grant-in-Aid for Young Scientists (A) (Grant No. 15H05430), and a Grant-in-Aid for Challenging Exploratory Research Grant (No. 15K13390) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Authors and Affiliations

  1. Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603, Japan

    Hiromasa Tanaka, Kenji Ishikawa, Masaaki Mizuno, Shinya Toyokuni, Hiroaki Kajiyama, Fumitaka Kikkawa & Masaru Hori

  2. Greifswald University Medicine, Ferdinand-Sauerbruch-Str. DZ 7, 17475, Greifswald, Germany

    Hans-Robert Metelmann

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  1. Hiromasa Tanaka
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Correspondence to Hiromasa Tanaka.

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Tanaka, H., Ishikawa, K., Mizuno, M. et al. State of the art in medical applications using non-thermal atmospheric pressure plasma. Rev. Mod. Plasma Phys. 1, 3 (2017). https://doi.org/10.1007/s41614-017-0004-3

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