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Comparison of 660-nm low-level and defocused 810-nm high-power laser for treatment of herpes labialis

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Abstract

Purpose

Laser therapy has been studied as a treatment for herpes labialis for some years. This study aimed to compare the efficacy of 660-nm low-level laser to defocused 810-nm high-power laser for treatment of herpes labialis.

Methods

In this single-blinded clinical trial study, evaluated 32 patients with herpes labialis in prodromic and early vesicle phase (first 48 h) were divided into two same groups by inclusion-extrusion criteria consideration and ethic codes. For group A low-level 660-nm diode laser (6 J/cm2, 100 mW, 0 Hz, 60 s, near contact, focal point of laser unit was 1 cm2) and for group B high-power defocused 810-nm diode laser (2 W, CW, 300-µ fiber, at 0.5-cm distance, 60 s, screening method from the center toward outer for 1-cm2 area) were used. Pain score changes, time of pain relief, lesion size changes, time of clinical healing, recurrence rate within 6 months, and the recurrence interval were recorded. Data were analyzed using the t-test, Chi-square test, Mann–Whitney test, and ANOVA.

Results

The pain intensity significantly decreased in both groups (P < 0.001) with no significant difference between them (P = 0.14). The time of pain relief was significantly shorter in group B (P = 0.003). The difference for the size of the lesion (P = 0.6) and time of clinical healing (P = 0.21) were not significant. The reduction in frequency of recurrence was not significantly different between the two groups (P = 0.55). The mean recurrence interval was significantly longer in group B (P = 0.002).

Conclusion

Two treatment methods had similar effects, but the defocused 810-nm high-power laser had better efficacy for shorter time of pain relief and longer recurrence interval in treatment of herpes labialis in this study.

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Authors and Affiliations

  1. School of Dentistry, Isfahan Branch, Islamic Azad University, Isfahan, Iran

    Mostafa Ahmadi

  2. Department of Oral Medicine, School of Dentistry, Isfahan Branch, Islamic Azad University, Isfahan, Iran

    Amir Mansour Shirani & Maryam Khosravi

  3. Department of Periodontology, School of Dentistry, Isfahan Branch, Islamic Azad University, Isfahan, Iran

    Shirin Zahra Farhad

  4. Klinik Für Zahnerhaltung, Universitätsklinikum Der Rheinisch-Westfaelischen Technischen Hochschule (RWTH), Parodontologie und Präventive Zahnheilkunde, Aachen, Germany

    Maziar Mir

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  1. Mostafa Ahmadi
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  4. Maryam Khosravi
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  5. Maziar Mir
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by all authors. The first draft of the manuscript was written by Amir Mansour Shirani and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Amir Mansour Shirani.

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Ethics approval

The study was approved by University (Research code was 23810201951020) by considering Ethic codes in Human Studies (1400–04-14–2-746).

Consent to participate

Informed consent was obtained from all individual participants included in the study.

Competing interests

The authors declare no competing interests.

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Amir Mansour Shirani has a fellowship of laser dentistry from RWTH Aachen University.

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Ahmadi, M., Shirani, A.M., Farhad, S.Z. et al. Comparison of 660-nm low-level and defocused 810-nm high-power laser for treatment of herpes labialis. Laser Dent Sci 6, 211–218 (2022). https://doi.org/10.1007/s41547-022-00164-z

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  • DOI: https://doi.org/10.1007/s41547-022-00164-z

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