Abstract
Recurrent herpes labialis (RHL) is a highly prevalent viral infection that affects the oro-facial region. Current treatment options have limited efficacy in reducing healing time and recurrence rate of the disease. Recently, low-level laser therapy has been proposed as a potential treatment alternative for the management of RHL with no side effects. This systematic review aims to evaluate the effectiveness of laser therapy in the management and prevention of RHL. A comprehensive search of Medline/PubMed, Scopus, and Web of Science was carried out to identify published clinical trials comparing laser intervention to active and/or non-active controls for the treatment of RHL. Due to marked heterogeneity of available data, studies were assessed qualitatively, and no statistical analysis was performed. Of the retrieved 227 articles, six clinical trials met the eligibility criteria. The wavelengths, the power output, and energy density ranged between 632.5–870 nm, 5–80 W, and 2.04–48 J/cm2, respectively. All included studies found laser to be effective in the management and prevention of RHL, without any side effects. The findings of this review suggest that laser is potentially a safe and effective treatment alternative for the management of RHL. However, due to high variability in study designs and inconsistency in laser parameters among the included studies, more well-designed randomized clinical trials with standardized laser parameters are highly warranted.
Similar content being viewed by others
References
Chen F, Xu H, Liu J, Cui Y, Luo X, Zhou Y et al (2017) Efficacy and safety of nucleoside antiviral drugs for treatment of recurrent herpes labialis: a systematic review and meta-analysis. J Oral Pathol Med 46:561–568
Arduino PG, Porter SR (2008) Herpes simplex virus type 1 infection: overview on relevant clinico-pathological features. J Oral Pathol Med 37(2):107–121
Arain N, Paravastu SC, Arain MA (2015) Effectiveness of topical corticosteroids in addition to antiviral therapy in the management of recurrent herpes labialis: a systematic review and meta-analysis. BMC Infect Dis 15:82
Al-Maweri SA, Al-Soneidar WA, Halboub ES (2014) Oral lesions and dental status among institutionalized orphans in Yemen: a matched case-control study. Contemp Clin Dent 5(1):81–84
Dougal G, Lee SY (2013) Evaluation of the efficacy of low-level light therapy using 1072 nm infrared light for the treatment of herpes simplex labialis. Clin Exp Dermatol 38(7):713–718
De Paula Eduardo C, Aranha ACC, Simões A, Bello-Silva MS, Ramalho KM, Esteves-Oliveira M et al (2014) Laser treatment of recurrent herpes labialis: a literature review. Lasers Med Sci 29(4):1517–1529
Sperandio FF, Marotti J, Aranha AC, Eduardo Cde P (2009) Photodynamic therapy for the treatment of recurrent herpes labialis: preliminary results. Gen Dent 57(4):415–419
Rahimi H, Mara T, Costella J, Speechley M, Bohay R (2012) Effectiveness of antiviral agents for the prevention of recurrent herpes labialis: a systematic review and meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol 113(5):618–627
Sanchez PJM, Femenias JLC, Tejeda AD, Tuner J (2012) The effect of 670-nm low laser therapy on herpes simplex type 1. Photomed Laser Surg 30(1):37–40
Honarmand M, Farhadmollashahi L, Vosoughirahbar E (2017) Comparing the effect of diode laser against acyclovir cream for the treatment of herpes labialis. J Clin Exp Dent 9(6):e729–ee32
Pandeshwar P, Roa MD, Das R, Shastry SP, Kaul R, Srinivasreddy MB (2016) Photobiomodulation in oral medicine: a review. J Investig Clin Dent 7(2):114–126
Al-Maweri SA, Kalakonda B, Al-Soneidar WA, Al-Shamiri HM, Alakhali MS, Alaizari N (2017) Efficacy of low-level laser therapy in management of symptomatic oral lichen planus: a systematic review. Lasers Med Sci 32(6):1429–1437
Suter VGA, Sjolund S, Bornstein MM (2017) Effect of laser on pain relief and wound healing of recurrent aphthous stomatitis: a systematic review. Lasers Med Sci 32(4):953–963
de Carvalho RR, Eduardo FD, Ramalho KM, Antunes JLF, Bezinelli LM, de Magalhaes M et al (2010) Effect of laser phototherapy on recurring herpes labialis prevention: an in vivo study. Lasers Med Sci 25(3):397–402
Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151(4):264–269 w64
Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD et al (2011) The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 343:d5928
Bello-Silva MS, de Freitas PM, Aranha AC, Lage-Marques JL, Simoes A, de Paula Eduardo C (2010) Low- and high-intensity lasers in the treatment of herpes simplex virus 1 infection. Photomed Laser Surg 28(1):135–139
Brignardello-Petersen R (2017) Treatment of lesions associated with herpes labialis with low level laser therapy may result in a decrease of pain and recovery time compared with acyclovir. J Am Dent Assoc 148(10):e153
Dougal G, Kelly P (2001) A pilot study of treatment of herpes labialis with 1072 nm narrow waveband light. Clin Exp Dermatol 26(2):149–154
Eduardo Cde P, Bezinelli LM, Eduardo Fde P, da Graca Lopes RM, Ramalho KM, Bello-Silva MS et al (2012) Prevention of recurrent herpes labialis outbreaks through low-intensity laser therapy: a clinical protocol with 3-year follow-up. Lasers Med Sci 27(5):1077–1083
Ferreira DC, Reis HLB, Cavalcante FS, dos Santos KRN, Passos MRL (2011) Recurrent herpes simplex infections: laser therapy as a potential tool for long-term successful treatment. Rev Soc Bras Med Trop 44(3):397–399
Gonzalez BM, Hernandez A, Estevez A (2008) Treatment of herpes simplex labialis with low power laser therapy. Colomb Med 39(2):175–181
Hargate G (2006) A randomised double-blind study comparing the effect of 1072-nm light against placebo for the treatment of herpes labialis. Clin Exp Dermatol 31(5):638–641
Marotti J, Sperandio FF, Fregnani ER, Aranha ACC, De Freitas PM, De Paula Eduardo C (2010) High-intensity laser and photodynamic therapy as a treatment for recurrent herpes labialis. Photomed Laser Surg 28(3):439–444
Prokhonchukov AA, Zhizhina NA, Banchenko GV, Milokhova EP, Saprykina VA, Kulazhenko TV et al (2006) Prevention and treatment of face herpes with magnetic-laser radiation from Optodan unit. Stomatologiia 85(3):78–82
Bojović M, Kesić L, Jovanović G, Burić N, Savić Z, Obradović R et al (2014) Application of soft laser in the treatment of herpes labialis—pilot study. Acta Stomatol Naissi 30(69):1342–1347
Schindl A, Neumann R (1999) Low-intensity laser therapy is an effective treatment for recurrent herpes simplex infection. Results from a randomized double-blind placebo-controlled study. J Investig Dermatol 113(2):221–223
Velez-Gonzalez M, Urrea-Arbelaez A, Nicolas M, Serra-Baldrich E, Perez J, Pavesi M, et al (1995) Treatment of relapse in herpes simplex on labial and facial areas and of primary herpes simplex on genital areas and “area pudenda” with low-power laser (He-Ne) or Acyclovir administered orally. SPIE Proc 2630:43–50
Ackermann G, Hartmann M, Scherer K, Lang EW, Hohenleutner U, Landthaler M et al (2002) Correlations between light penetration into skin and the therapeutic outcome following laser therapy of port-wine stains. Lasers Med Sci 17(2):70–78
Ishii J, Fujita K, Komori T (2003) Laser surgery as a treatment for oral leukoplakia. Oral Oncol 39(8):759–769
Arbabi-Kalati F, Bakhshani NM, Rasti M (2015) Evaluation of the efficacy of low-level laser in improving the symptoms of burning mouth syndrome. J Clin Exp Dent 7(4):e524–e527
Mizutani K, Musya Y, Wakae K, Kobayashi T, Tobe M, Taira K et al (2004) A clinical study on serum prostaglandin E2 with low-level laser therapy. Photomed Laser Surg 22(6):537–539
Al-Maweri SA, Javed F, Kalakonda B, AlAizari NA, Al-Soneidar W, Al-Akwa A (2017) Efficacy of low level laser therapy in the treatment of burning mouth syndrome: a systematic review. Photodiagn Photodyn Ther 17:188–193
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
This study was approved by the ethical committee at AlFarabi Colleges for Dentistry and Nursing, Riyadh, Saudi Arabia. Owing to the fact that this is a systematic review, no consent form was needed. Moreover, this article does not comprise any studies with human subjects or animals conducted by any of the authors. This study was self-funded by the authors.
Conflict of interest
The authors declare that they have no conflict of interest.
Electronic supplementary material
ESM 1
(DOCX 27.9 kb)
Rights and permissions
About this article
Cite this article
Al-Maweri, S.A., Kalakonda, B., AlAizari, N.A. et al. Efficacy of low-level laser therapy in management of recurrent herpes labialis: a systematic review. Lasers Med Sci 33, 1423–1430 (2018). https://doi.org/10.1007/s10103-018-2542-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10103-018-2542-5