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Metabolomic approach for obstructive sleep apnea in adults: a systematic review

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A Correction to this article was published on 13 July 2023

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Abstract

Obstructive Sleep Apnea (OSA) corresponds to episodes of complete or partial upper airway obstruction during sleep. The gold standard for diagnosing OSA is polysomnography; however, metabolomics is an innovative and highly sensitive method that seeks to identify and quantify small molecules in biological systems. Identify the metabolites most frequently associated with obstructive sleep apnea in adults. The search for articles was conducted between October 2020 and August 2021, in electronic databases, such as MEDLINE/PubMed, Scielo, Embase, and Cochrane, through the combination of descriptors: obstructive sleep apnea, metabolomic, adult. This systematic review included all cross-sectional studies published, including human patients aged 18 years or older, of both genders who underwent type I or II polysomnography and metabolomics study. The search strategy selected 3697 surveys, and 4 of them were selected to be a part of this systematic review. Based on the analyzed surveys, it was found that all of them were able to diagnose OSA, reaching a sensitivity of 75–97%, and specificity that ranged from 72 to 100%; besides differentiating patients with OSA (severe, moderate, and mild) from simple snorers with a mean sensitivity of 77.2% and specificity of 66.25%. These findings suggest that, in addition to being used as a screening and diagnostic strategy for OSA, metabolomics has the potential to be used for severity stratification and to monitor the disease's progression.

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Funding

This survey is funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) under Grant No. 126739/2020-0.

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Authors and Affiliations

  1. International Center on Clinical Sleep Medicine and Research, Bahiana School of Medicine and Public Health, Salvador, Brazil

    Cristina Salles, Maria Clara Freitas, Amancio Souza, Paulo Ribeiro, Cristiane Dias, Michele Rosa & Miguel Meira e Cruz

  2. Public Health Sciences, University of California, San Diego, USA

    Amancio Souza

  3. Chemistry Institute, Federal University of Bahia, Salvador, Brazil

    Paulo Ribeiro

  4. Cardiovascular Centre of University of Lisboa, CCUL, Falculty of Medicine, University of Lisboa, Lisboa, Portugal

    Michele Rosa

  5. Centro Europeu do Sono, European Center of Sleep, Lisboa, Portugal

    Miguel Meira e Cruz

  6. Faculty São Leopoldo Mandic, Faculty São Leopoldo Mandic, Campinas, Brazil

    Miguel Meira e Cruz

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  1. Cristina Salles
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  2. Maria Clara Freitas
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Correspondence to Cristina Salles.

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Salles, C., Freitas, M.C., Souza, A. et al. Metabolomic approach for obstructive sleep apnea in adults: a systematic review. Sleep Biol. Rhythms 21, 265–277 (2023). https://doi.org/10.1007/s41105-023-00445-5

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