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Emerging role of metabolomics for biomarker discovery in obstructive sleep apnea

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Abstract

Obstructive sleep apnea (OSA) is characterized by the complete or partial blockage of the upper airway passage during sleep which causes repetitive breaks in sleep and may result in excessive daytime sleepiness. OSA has been linked to various metabolic disorders and chronic health conditions, such as obesity, diabetes, hypertension, and depression. Profiling of alterations in metabolites and their regulation in OSA has been hypothesized to be an effective approach for early diagnosis and prognosis of OSA. Several studies have characterized metabolic fingerprints associated with sleep disorders. There is a lack of understanding of metabolite contents and their alterations in OSA that may help to identify specific biomarkers. The information provided in this review will help update new methodologies and interventions of high throughput advanced molecular/metabolomics tools which may clarify the metabolic aspects and mechanisms for improved management and treatment of OSA.

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Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

Abbreviations

AHI:

Apnea–hypopnea index

BMI:

Body mass index

CPAP:

Continuous positive airway pressure

GC:

Gas chromatography

HPLC:

High-performance liquid chromatography

LC:

Liquid chromatography

MAD:

Mandibular advancement device

MS:

Mass spectrometry

OSA:

Obstructive sleep apnea

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Funding

Mohit is supported by Indian Council of Medical Research for Senior Research Fellowship Award. Manendra Singh Tomar is a recipient of Junior research fellowship from the University Grants Commission, Government of India. Extramural research grant from the Indian Council of Medical Research to Pooran Chand is highly acknowledged. Laboratory of Ashutosh Shrivastava is supported by CCRH-Ministry of AYUSH, Government of India and KGMU intramural grant.

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Authors and Affiliations

  1. Department of Prosthodontics, King George’s Medical University Lucknow, Uttar Pradesh, Lucknow, 226003, India

    Mohit & Pooran Chand

  2. Center for Advance Research, King George’s Medical University Lucknow, Uttar Pradesh, Lucknow, 226003, India

    Mohit, Manendra Singh Tomar, Ankit Pateriya & Ashutosh Shrivastava

  3. Council of Scientific & Industrial Research, Phytochemistry Division, National Botanical Research Institute, Uttar Pradesh, Lucknow, 226001, India

    Deepak Sharma

  4. Department of Biotechnology, Era’s Lucknow Medical College & Hospital, Uttar Pradesh, Lucknow, 226003, India

    Shiv Nandan

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  1. Mohit
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  2. Manendra Singh Tomar
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  3. Deepak Sharma
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  4. Shiv Nandan
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  5. Ankit Pateriya
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  6. Ashutosh Shrivastava
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  7. Pooran Chand
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Contributions

M, PC, and AS conceptualized the idea and evaluated the manuscript. M, MST, SN, and DS drafted the manuscript. All authors concur to the final version of the manuscript.

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Correspondence to Ashutosh Shrivastava or Pooran Chand.

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Mohit, Tomar, M.S., Sharma, D. et al. Emerging role of metabolomics for biomarker discovery in obstructive sleep apnea. Sleep Breath 27, 1247–1254 (2023). https://doi.org/10.1007/s11325-022-02730-y

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