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The Role of Krüppel-like Factor 4 (KLF4) Gene in Breast Cancer Tissue Samples: A Systematic Review and Meta-analysis

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  • Published:
Indian Journal of Gynecologic Oncology Aims and scope Submit manuscript

Abstract

Background

Breast cancer is the most common cancer and the primary cause of mortality due to cancer in female around the World. As a result, the aim of this research is to conduct a comprehensive systematic review and meta-analysis to determine the role of Krüppel-like factor 4 (KLF4) as the main gene expression in breast cancer tissue.

Methods

The studies used in this systematic review were selected from the articles published from up to February 1, 2020, in national and international databases including SID, WoS, Magiran, PubMed, Scopus, IranDoc, Science Direct, IranMedix as well as Google Scholar.

Results

From the systematic review, a meta-analysis was performed on 8 articles which were satisfied the inclusion criteria. The sample including 869 individuals was then selected to perform the meta-analysis. Based on the results derived from this meta-analysis, the total expression of klf4 gene in breast cancer tissue’s samples was 60.1% (95% CI: 45.1–73.4%). The highest and lowest Klf4 gene expression levels in breast cancer tissue samples were obtained 89.7% in Alabama in 2004 (95% CI: 83.7–93.7%) and 32.1% in Japan in 2016 (95% CI: 23.1–42.8%), respectively. The results showed that with increasing sample size and year of publication, klf4 gene expression was reduced in breast cancer tissue samples, which was statistically significant (P < 0.05).

Conclusion

Identifying the expression profiles of genes involved in breast cancer using its various pathway inhibitors can address many challenges for researchers and is very important for advancing cancer health and treatment.

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Availability of data and materials

Datasets are available through the corresponding author upon reasonable request.

Abbreviations

KLF4:

Krüppel-like factor 4

SID:

Scientific Information Database

PRISMA:

Preferred Reporting Items for Systematic Reviews and Meta-Analysis

IDC:

Invasive Ductal Carcinoma

STROBE:

Strengthening the reporting of observational studies in epidemiology

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Acknowledgements

The authors thank the Student Research Committee, Kermanshah University of Medical Sciences.

Funding

By Deputy for Research and Technology, Kermanshah University of Medical Sciences (IR) (3010779). This deputy has no role in the study process.

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Authors and Affiliations

  1. Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Nader Salari

  2. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Shabnam Rasoulpoor & Shna Rasoulpoor

  3. Medical Biology Research Centre, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Kamran Mansouri

  4. Department of Biology, Faculty of Science, University Putra Malaysia, Serdang, Selangor, Malaysia

    Shamarina Shohaimi

  5. Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran

    Masoud Mohammadi

Authors
  1. Nader Salari
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  2. Shabnam Rasoulpoor
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  3. Shna Rasoulpoor
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  4. Kamran Mansouri
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  5. Shamarina Shohaimi
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Contributions

NS and KM, MM contributed to the design. MM carried out the statistical analysis and participated in most of the study steps. SHSH, MM prepared the manuscript. SHSH and SHR1, SHR2 assisted in designing the study and helped in the interpretation of the study. All authors have read and approved the content of the manuscript.

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Correspondence to Masoud Mohammadi.

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The authors declare that they have no conflict of interest.

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Ethics approval was received from the ethics committee of deputy of research and technology, Kermanshah University of Medical Sciences (3010779).

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Salari, N., Rasoulpoor, S., Rasoulpoor, S. et al. The Role of Krüppel-like Factor 4 (KLF4) Gene in Breast Cancer Tissue Samples: A Systematic Review and Meta-analysis. Indian J Gynecol Oncolog 20, 7 (2022). https://doi.org/10.1007/s40944-022-00605-4

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  • DOI: https://doi.org/10.1007/s40944-022-00605-4

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