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Prognostic significance of NANOG and KLF4 for breast cancer

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Abstract

Background

Some of the induced pluripotent stem cell (iPS cell)-inducing factors have been reported to be expressed in breast cancer. The aim of the present study was to examine the relationship between the expression of iPS cell-inducing factors and the prognosis of breast cancer patients.

Methods

In 100 breast cancer patients, the expression of c-MYC, KLF4, NANOG, OCT4, and SOX2 was determined by immunohistochemistry using a tissue microarray analysis.

Results

Patients with strong expression of NANOG had significantly lower disease-free survival (DFS) and overall survival rates than those with weak expression of NANOG (P = 0.004 and 0.033, respectively). In contrast, patients with strong expression of KLF4 had better DFS (P = 0.014).

Conclusions

Strong expression of NANOG is an indicator of a poor prognosis for breast cancer patients, whereas KLF4 is a favorable prognostic indicator. Our results suggest that NANOG stimulates the growth and metastasis of breast cancer cells, whereas KLF4 inhibits these processes.

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Acknowledgments

We are grateful to Dr. T. Hori for the valuable technical assistance. This study was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Surgery and Science, Graduate School of Research Into Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, Toyama, Japan

    Takuya Nagata, Yutaka Shimada, Shinichi Sekine, Ryota Hori, Koshi Matsui, Tomoyuki Okumura, Shigeaki Sawada & Kazuhiro Tsukada

  2. Department of Pathology, Graduate School of Research Into Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, Toyama, Japan

    Junya Fukuoka

Authors
  1. Takuya Nagata
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  2. Yutaka Shimada
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  3. Shinichi Sekine
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  4. Ryota Hori
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  5. Koshi Matsui
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  6. Tomoyuki Okumura
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  7. Shigeaki Sawada
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  8. Junya Fukuoka
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  9. Kazuhiro Tsukada
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Corresponding author

Correspondence to Takuya Nagata.

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Nagata, T., Shimada, Y., Sekine, S. et al. Prognostic significance of NANOG and KLF4 for breast cancer. Breast Cancer 21, 96–101 (2014). https://doi.org/10.1007/s12282-012-0357-y

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  • DOI: https://doi.org/10.1007/s12282-012-0357-y

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