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Biodegradable Polyphosphazenes for Biomedical Applications

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Abstract

Polyphosphazenes are an important class of biodegradable polymers with immense biomedical potential. These polymers consist of an inorganic backbone of -P = N- repeating units and variable organic side groups. Inorganic–organic hybrid polyphosphazenes project an ensemble of interesting properties such as biocompatibility, unique degradation behaviour with metabolizable by-products, easy synthesis and chemical modifications, and variable physical and chemical properties, which makes them interesting candidates for regenerative engineering, drug delivery, bioresorbable sutures, bioimaging, coatings, etc. to name a few. This review discusses polyphosphazene synthesis and chemistry, in vitro and in vivo biocompatibility, and degradation behaviour, and summarizes the biomedical advances made using polyphosphazenes in the last few decades.

Lay Summary

Polymers play a very important role in our daily lives. In the last few decades, polymers are being considered for different biomedical applications like resorbable sutures and degradable implants. Polyphosphazenes are a unique class of biodegradable polymers whose degradation by-products that can be easily absorbed by our bodies. This review introduces polyphosphazene synthesis and its properties and gives an overview of the different biomedical applications for which these polymers have been explored.

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Acknowledgements

Support from NIH/NIAMS T32 ARO79114 (to CTL), Building Infrastructure Leading to Diversity (BUILD) TL4GM118971 (to CTL), and Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences are gratefully acknowledged.

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Authors and Affiliations

  1. The Cato T. Laurencin Institute for Regenerative Engineering, UConn Health, Farmington, CT, USA

    Manaswee Barua, Oyindamola R. Teniola & Cato T. Laurencin

  2. Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA

    Oyindamola R. Teniola

  3. Department of Orthopaedic Surgery, UConn Health, Farmington, CT, USA

    Cato T. Laurencin

  4. Institute of Materials Science, University of Connecticut, Storrs, CT, USA

    Cato T. Laurencin

  5. Department of Materials Science and Engineering, University of Connecticut, Storrs, CT, USA

    Cato T. Laurencin

  6. Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT, USA

    Cato T. Laurencin

  7. Department of Material Science and Engineering, University of Connecticut, Storrs, CT, USA

    Cato T. Laurencin

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  1. Manaswee Barua
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Barua, M., Teniola, O.R. & Laurencin, C.T. Biodegradable Polyphosphazenes for Biomedical Applications. Regen. Eng. Transl. Med. (2023). https://doi.org/10.1007/s40883-023-00318-w

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