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Highly flexible and controllable hierarchical MOF membrane for efficient drug release

高度灵活可控的多孔MOF膜用于高效药物释放

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Abstract

An active wound dressing that is biomechanically and biochemically effective is essential for wound care and skin tissue regeneration. Despite its importance, issues persist with mechanical compatibility and drug release control, restricting the optimal use of existing dressings. In this work, we present a simple approach using a poly (vinylidene fluoride) (PVDF) substrate containing zeolitic imidazolate framework (ZIF-8) seeds of different sizes to start the precise development of a highly flexible metal-organic framework membrane with a consistent honeycomb structure, suitable for drug loading and release. With the embedded seeds serving as a control center, the honeycomb membrane formed features pore openings ranging from 0.7 to 3 µm. These adjustable microscale pores, combined with the intrinsic nanopores in ZIF-8, facilitate efficient loading of the anti-inflammatory drug curcumin (CCM) and enable its rapid and controlled release for antibacterial activity and cell growth. Among these, the 0.7-µm honeycomb membrane produced on the 40-nm seed showed a 2-fold increase in cell proliferation compared with the honeycomb membrane (equal to the bare PVDF substrate). Furthermore, it displayed 5 and 2.4 times greater antibacterial activity against Staphylococcus aureus and Escherichia coli than the substrate. These results are attributable to the balanced influence of CCM and Zn2+ release properties from such ideal pore geometries. The controllable and hierarchical pore-arrayed membrane boasts unique characteristics that make it a promising option for wound healing. Additionally, it offers valuable insights for the design of future biomedicine applications.

摘要

具有生物力学和生化活性的敷料在伤口护理和皮肤组织再生中 起着至关重要的作用. 然而, 机械失配和药物释放管理所涉及的问题限 制了当前敷料的有效使用. 在本工作中, 我们报道了一种简单的策略, 即采用聚偏二氟乙烯(PVDF)作为底物, 通过嵌入不同尺寸的沸石咪唑 酸盐框架(ZIF-8)种子, 以推动具有均匀蜂窝结构的高柔性金属有机框 架(MOF)复合膜的受控生长, 用于药物负载和释放. 以嵌入的种子为控 制中心, 形成的多孔膜具有约0.7–3µm的宽孔隙. 这种可调节的微尺度 孔与ZIF-8中的固有纳米孔不仅可以有效地提高抗炎类药物的负载(姜 黄素, CCM), 而且还能够快速并可控地释放药物, 大大提高了抗菌活 性, 同时促进细胞生长. 其中, 在40 nm 种子上生长的0.7 µm 多孔膜的 表现优于其他蜂窝膜, 与2 µm 多孔膜(相当于裸PVDF 基质)相比, 细 胞增殖能力提高了约2倍, 针对金黄色葡萄球菌(S. aureus)和大肠杆菌 (E. coli)的抗菌活性分别提高了5倍和2.4倍, 是基底抗菌活性的5倍, 这 是因为这种最佳孔几何结构具有CCM 和Zn2+ 释放特性的平衡效应. 这种可控分层孔阵列膜的独特性质有望真正用于伤口愈合, 同时也为 生物医学设计提供了新的指导.

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (52371248), National Key R&D Program of China (2021YFB3802200), Guangdong Basic and Applied Basic Research Foundation (2023A1515010905) and the Scientific and Technological Innovation Foundation of Shunde Graduate School, USTB (BK22BE012). Lee HK thanks the funding supports from Singapore Ministry of Education (AcRF Tier 1 RS13/20 and RG4/21), A*STAR Singapore (AME YIRG A2084c0158), the Center ofHydrogen Innovation, National University of Singapore (CHI-P2022-05), and Nanyang Technological University Startup Grants.

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China

    Jiaxin Li  (李家馨), Yachao Yan  (鄢亚超), Qinglin Fang  (房庆霖), Yingzhi Chen  (陈颖芝) & Lu-Ning Wang  (王鲁宁)

  2. Shunde Graduate School of University of Science and Technology Beijing, Foshan, Guangdong, 528399, China

    Yingzhi Chen  (陈颖芝), Qihang Jing  (景启航) & Lu-Ning Wang  (王鲁宁)

  3. School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore

    Hiang Kwee Lee

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  1. Jiaxin Li  (李家馨)
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  3. Qinglin Fang  (房庆霖)
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Contributions

Author contributions Li J conducted the experiments, processed the data, and wrote the paper. Fang Q drew some illustrations. Yan Y conceived the work and wrote the paper. Chen Y wrote the paper. Lee HK edited and reviewed paper. Wang LN supervised the project. All the authors contributed to the general discussion. All authors read and agreed to the published version of the manuscript.

Corresponding authors

Correspondence to Yingzhi Chen  (陈颖芝), Hiang Kwee Lee or Lu-Ning Wang  (王鲁宁).

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Conflict of interest The authors declare that they have no conflict of interest.

Additional information

Supplementary information Supporting data are available in the online version of the paper.

Yingzhi Chen is an associate Professor at the School of Materials Science and Engineering, University of Science and Technology Beijing. She received her PhD degree in chemistry from the Institute of Technical Institute of Physics & Chemistry, Chinese Academy of Sciences in 2012 after she got her MS degree in chemistry from Beijing Normal University. Her current research focuses on the design and synthesis of novel organic semiconductor nanocrystals and their applications in photocatalysis and biosensing.

Lu-Ning Wang is a Professor at the School of Materials Science and Engineering, University of Science and Technology Beijing. He received his BE and MS degrees in materials science and engineering from the University of Science and Technology Beijing, in 2002 and Tsinghua University in 2005, respectively. He received another BE and PhD degrees in medical science and biomedical engineering from the University of Alberta in 2007 and 2011, respectively. His research interests include optoelectronic materials and biodgradable materials.

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Li, J., Yan, Y., Fang, Q. et al. Highly flexible and controllable hierarchical MOF membrane for efficient drug release. Sci. China Mater. 67, 1509–1520 (2024). https://doi.org/10.1007/s40843-024-2909-9

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  • DOI: https://doi.org/10.1007/s40843-024-2909-9

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