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Room-temperature and gram-scale constructed Cu@CuO with promoted kinetics for glucose electrooxidation in the Faraday process

室温克级构筑Cu@CuO及其在法拉第葡萄糖电氧化过程中的动力学提升机制

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Abstract

In clinical applications, disposable strip glucose sensors can monitor and maintain daily glucose levels for diabetes to prevent and avoid life-threatening complications. In this paper, gram-scale Cu@CuO was synthesized via a controlled in-situ oxidation process of commercial Cu at room temperature. As a catalytic material for glucose electrooxidation in sensors, Cu@CuO is screen-printed onto silver-carbon working/counter electrodes. The obtained electrodes exhibit enhanced electrocatalytic behaviors for glucose oxidation, including a low limit of detection (1.3 µmol L−1) with a corresponding linear range (0.0013–2.5 mmol L−1), good selectivity, repeatability (20 electrodes with 4.28% relative standard deviation), high sensitivity (0.03 µA mmol−1 L cm−2), as well as air storage stability for more than three weeks. Calculation results show that the Cu component can not only increase the electronic conductivity, but also enhance the glucose adsorption ability of Cu@CuO, leading to a promoted kinetics in the Faraday process. More significantly, the large-scale preparation and wide applications in clinical electrodes make Cu@CuO a considerable and sustainable improvement for non-enzymatic glucose sensing applications.

摘要

在临床应用中, 一次性条形血糖传感器可以日常监测和维持糖尿病患者的血糖水平, 以预防和避免危及生命的并发症. 本文采用室温可控原位氧化商业铜的工艺制备了Cu@CuO材料. 将具有电催化性能的Cu@CuO丝网印刷到一次性银碳工作电极上, 制备了条形无酶葡萄糖传感器. 该传感器对葡萄糖的电催化氧化表现出优异的性能: 高灵敏度(0.03 µA mmol−1 L cm−2)、 低检测限(1.3 µmol L−1)、 宽线性范围(0.0013–2.5 mmol L−1)、良好的选择性、 重复性(20个电极的相对标准偏差为4.28%), 以及在室温下超过3周的稳定性. 计算结果表明, 铜组分提高了Cu@CuO的导电性和对葡萄糖的吸附能力, 从而改善了其在葡萄糖法拉第催化过程中的动力学性能. 更重要的是, Cu@CuO的批量制备及其在临床型电极中的应用为其在无酶血糖传感方面的应用提供了一个参考方案.

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Acknowledgements

This work was financially supported by the Scientific Research Start-up Funds of Hexi University (KYQD2022004) and the 13th Innovation Program Science and Technology for college students of Hexi University (138). The authors would like to thank Prof. Zhenlai Liu of Hexi University for the initial support of laboratory construction.

Author information

Authors and Affiliations

  1. Institute of New Energy, Hexi University, Zhangye, 734000, China

    Suyuan Li  (李苏原), Cheng Cao  (曹成), Siyang Li  (李思阳), Xiaojun Wang  (王小军), Na Tian  (田娜) & Junhua Luo  (罗均华)

  2. Cofoe Medical Technology Co., Ltd, Changsha, 410000, China

    Haiyan Xia  (夏海艳), Lixia Liu  (刘丽霞) & Changyun Quan  (全昌云)

  3. School of Materials and Energy, Lanzhou University, Lanzhou, 730000, China

    Yanpeng Liu  (刘彦鹏) & Shanglong Peng  (彭尚龙)

  4. School of Chemistry and Chemical Engineering, Suzhou University, Suzhou, 234000, China

    Pengfei Lu  (路鹏飞)

Authors
  1. Suyuan Li  (李苏原)
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  2. Haiyan Xia  (夏海艳)
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  3. Yanpeng Liu  (刘彦鹏)
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  4. Cheng Cao  (曹成)
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  5. Siyang Li  (李思阳)
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  8. Lixia Liu  (刘丽霞)
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  11. Junhua Luo  (罗均华)
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  12. Shanglong Peng  (彭尚龙)
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Contributions

Author contributions Li S designed, engineered, characterized, and analyzed the samples with the support from Liu Y, Cao C, Li S, Wang X, Tian N, Peng S and Luo J; Xia H, Quan C, and Liu L performed the electrochemical experiments; Lu P built the models and performed the calculations. Li S wrote the paper with the support from Xia H and Peng S. All authors contributed to the general discussion.

Corresponding authors

Correspondence to Suyuan Li  (李苏原), Pengfei Lu  (路鹏飞), Changyun Quan  (全昌云) or Shanglong Peng  (彭尚龙).

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Conflict of interest The authors declare that they have no conflict of interest.

Additional information

Suyuan Li received his PhD degree from Lanzhou University in 2015. He works as an associate professor at Hexi University. His current research interests are focused on biosensors and lithium ion battery.

Changyun Quan is pursuing his PhD degree at the School of Chemistry and Chemical Engineering, Central South University. Since 2020, he has been working at Cofoe Medical Technology Co., Ltd. engaged in the development of biosensors. His current research interest is focused on developing a series of portable chronic disease detection and monitoring systems.

Shanglong Peng is a professor of Lanzhou University. From 2010 to 2016, he worked at the University of Washington, Seoul National University and the Hong Kong University of Science and Technology. Currently, he is mainly engaged in the design of nanomaterials, interface regulation and their applications in energy conversion and storage, including supercapacitors, solar cells and flexible wearable integrated energy conversion and storage integrated devices.

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Li, S., Xia, H., Liu, Y. et al. Room-temperature and gram-scale constructed Cu@CuO with promoted kinetics for glucose electrooxidation in the Faraday process. Sci. China Mater. 66, 4396–4402 (2023). https://doi.org/10.1007/s40843-023-2588-4

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  • DOI: https://doi.org/10.1007/s40843-023-2588-4

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