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Development of a Non-Enzyme Sensor to Detect Glucose Based on the Modification of Copper Electrode

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Abstract

In this paper, the Cu/Cu2O and Cu/Cu2O/CuO electrodes were successfully fabricated from the copper layer of a printed circuit board using an electrical oxidation method. The physical properties of these samples were verified through X-Ray diffraction and scanning electron microscopy (SEM) measurements. The Cu/Cu2O and Cu/CuO/Cu2O electrodes were employed as non-enzyme sensors for the detection of glucose in the alkaline solution. The properties of electrodes were investigated using cyclic voltammetry and amperometry measurements with glucose solution. The results show that both types of electrodes can detect and quantify glucose concentrations. The Cu/Cu2O/CuO composite electrode demonstrated superior performance compared to the Cu/Cu2O electrode. The proposed sensor demonstrated a limit of detection of approximately 63.08 nM. Additionally, the proposed sensor was also investigated with various interfering substances, including ascorbic acid, urea, and table salt. The results revealed that the current intensity remained nearly unchanged for these substances, while it significantly increased from 0.3 to 2.5 mA/cm2 for glucose. With these achieved results, the developed system shows promise for application in glucose testing systems, benefiting diabetic patients in the future.

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Acknowledgements

This work was funded by the Vietnam Ministry of Science and Technology under Grant NĐT.101.TW/21. Chi Tran Nhu was funded by the Master, PhD Scholarship Programme of Vingroup Innovation Foundation (VINIF), code VINIF.2023.TS.016.

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  1. Faculty of Electronics and Telecommunications, University of Engineering and Technology, Vietnam National University, 144 Xuan Thuy Street, Cau Giay District, Hanoi, Vietnam

    Chi Tran Nhu, Tung Bui Thanh, Trinh Chu Duc & Phu Nguyen Dang

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  1. Chi Tran Nhu
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  2. Tung Bui Thanh
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Correspondence to Phu Nguyen Dang.

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Tran Nhu, C., Bui Thanh, T., Chu Duc, T. et al. Development of a Non-Enzyme Sensor to Detect Glucose Based on the Modification of Copper Electrode. Arab J Sci Eng (2023). https://doi.org/10.1007/s13369-023-08594-y

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