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Multifunctional Cu1.94S-Bi2S3@polymer nanocomposites for computed tomography imaging guided photothermal ablation

多功能Cu1.94S-Bi2S3@polymer纳米探针用于CT成像指导的光热治疗

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Abstract

The doping of radiocontrast agent such as bismuth (Bi) in copper chalcogenide nanocrystals for computed tomography (CT) imaging guided photothermal therapy (PTT) has drawn increasing attention. However, the doping of Bi often suffers from the weak CT signal due to the low Bi doping concentration and deteriorates the PTT efficacy of copper chalcogenides. Here we report a multifunctional nanoprobe by encapsulating both Cu1.94S and Bi2S3 nanocrystals into a biocompatible poly(amino acid) matrix with size of ~85 nm for CT imaging guided PTT. The amount of nanocrystals and the ratio of Cu1.94S-to-Bi2S3 in the multifunctional nanocomposites (NCs) are tunable toward both high photothermal conversion efficiency (~31%) and excellent CT imaging capability (27.8 HU g L−1). These NCs demonstrate excellent effects for photothermal ablation of tumors after intratumoral injection on 4T1 tumor-bearing mice. Our study may provide a facile strategy for the fabrication of multi-functional theranostics towards simultaneous strong CT signal and excellent PTT.

摘要

铋掺杂硫化铜纳米晶用于CT成像指导的光热治疗已经引起了人们的广泛关注. 然而, 低剂量的铋掺杂CT信号弱, 高剂量铋掺杂又会减弱硫化铜的光热效果. 本文报道了一种多功能纳米探针, 用两亲性高分子将油溶性Cu1.94S和Bi2S3纳米晶同时封装于约85 nm大小的纳米微球中,用于CT成像指导光热治疗. 多功能纳米探针中Cu1.94S和Bi2S3纳米晶的量和比例能够灵活调节, 从而得到较高的光热转换效率(~31%)和良好的CT成像能力(27.8 HU g L−1). 这些纳米探针在4T1荷瘤小鼠进行瘤内注射后, 显示了良好的CT成像与肿瘤光热治疗效果. 该复合纳米探针的制备方法还可用于其他多功能纳米探针的制备.

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Acknowledgements

This research was supported in part by the National Natural Science Foundation of China (21475007 and 21675009), and the Fundamental Research Funds for the Central Universities (buctrc201608 and buctrc201720). We also thank Prof. X. Zhang of Xiamen University for the help on the in vivo CT imaging and PTT, and the support from the “Public Hatching Platform for Recruited Talents of Beijing University of Chemical Technology”.

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Authors and Affiliations

  1. State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, 100029, China

    Xiaoquan Lu  (鹿晓泉), Yuanbao Li  (李远豹), Xilin Bai  (白熙林), Gaofei Hu  (胡高飞) & Leyu Wang  (汪乐余)

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  1. Xiaoquan Lu  (鹿晓泉)
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  2. Yuanbao Li  (李远豹)
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  3. Xilin Bai  (白熙林)
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  4. Gaofei Hu  (胡高飞)
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  5. Leyu Wang  (汪乐余)
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Correspondence to Leyu Wang  (汪乐余).

Additional information

Author contributions Wang L proposed the research direction and guided the project. Lu X, Li Y and Bai X designed and performed the experiments. Lu X, Hu G and Wang L analyzed and discussed the experimental results, and drafted the manuscript. All the authors checked and approved the manuscript.

Conflict of interset The authors declare that they have no conflict of interest.

Supplementary information Experimental details are available in the online version of the paper.

Xiaoquan Lu is currently a third-year Master candidate in chemistry under the supervision of Prof. Leyu Wang at Beijing University of Chemical Technology (BUCT) since 2014. His research interest is focused on CT imaging and photothermal ablation.

Leyu Wang is a professor of chemistry at BUCT. He received his PhD in chemistry from Tsinghua University with Prof. Yadong Li in 2007. Then he joined Prof. Huang’s group at the University of California at Los Angeles (UCLA) as a postdoctoral researcher from 2007–2009. He moved to BUCT’s Chemistry Department in October 2009. His research interests span from the controlled synthesis of upconversion luminescence nanoparticles (UCNPs), localized surface plasmon resonance (LSPR) near-infrared (NIR) semiconductor NPs, magnetic nanomaterials, metal-semiconductor heteronanostructures, and molecularly imprinted polymers (MIPs) nanomaterials to the applications including electrocatalysis, artificial photosynthesis, biochemical sensing, multimodal imaging, drug/gene delivery and photothermo/chemo therapy.

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Lu, X., Li, Y., Bai, X. et al. Multifunctional Cu1.94S-Bi2S3@polymer nanocomposites for computed tomography imaging guided photothermal ablation. Sci. China Mater. 60, 777–788 (2017). https://doi.org/10.1007/s40843-017-9068-6

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  • DOI: https://doi.org/10.1007/s40843-017-9068-6

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