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Facile synthesis of liposome/Cu2−x S-based nanocomposite for multimodal imaging and photothermal therapy

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Abstract

A kind of multifunctional perfluoropentane (PFP) and ultrasmall Cu2−xS nanodots (u-Cu2−xS NDs) co-incorporated liposome (PFP@ u-Cu2−xS NDs@liposome) nanocomposite has been facilely and successfully synthesized for enhanced ultrasound/infrared thermal/photoacoustic multimodal imaging and photothermal therapy upon near infrared (NIR) laser irradiation. Such a liposome-based nanocomposite possesses a number of advantages, such as high dispersity and stability, excellent biocompatibility, small particle size (<100 nm), well-defined core/shell structure, strong NIR absorption and photo-triggered vaporization of PFP, etc. The detailed in vitro investigations demonstrate that the as-synthesized PFP@ u-Cu2−xS NDs@ liposome nanocomposite is capable of enhancing the contrasts of ultrasound/infrared thermal/photoacoustic multimodal imaging, and substantially improving the photothermal therapeutic efficacy. This novel liposome-based theranostic nanoplatform shows great potentials in the future cancer diagnosis and therapy.

摘要

包裹氟碳化合物的脂质体已被广泛用作超声成像造影剂; 而硫化铜由于具有表面等离子体共振效应在近红外区域具有强光学吸收特性, 可以同时作为一种性能优异的近红外热/光声成像造影剂和光热治疗剂. 本文以有机脂质体为载体, 同时包裹氟碳化合物和硫化铜, 在近红外激光照射下, 硫化铜吸收光能将其转化为热能, 达到氟碳化合物的相变温度时使氟碳化合物 由液态变为气态, 产生的气泡可增强超声成像造影能力, 从而构建了单一波长激光诱导的超声/近红外热/光声多模式成像引导下的光热治疗, 极大提高了癌症治疗的安全性和治疗效率. 体外实验结果表明该有机无机复合物不仅能克服单纯有机脂质体的不稳定性等缺点, 而且具有显著增强的多模式成像造影能力和优异的光热治疗效果, 具有重要的临床应用前景.

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Authors and Affiliations

  1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China

    Juan Mou, Yu Chen, Ming Ma, Kun Zhang, Chenyang Wei, Hangrong Chen & Jianlin Shi

Authors
  1. Juan Mou
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  2. Yu Chen
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  3. Ming Ma
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  4. Kun Zhang
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  5. Chenyang Wei
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  6. Hangrong Chen
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  7. Jianlin Shi
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Corresponding authors

Correspondence to Hangrong Chen or Jianlin Shi.

Additional information

Juan Mou received her BSc degree at China University of Geosciences (Wuhan) (2007). She is now a PhD candidate at Shanghai Institute of Ceramics, Chinese Academy of Sciences (SICCAS). Her research interest includes the design, synthesis and biomedical applications of novel photothermal and photodynamic therapy materials.

Hangrong Chen received her PhD degree in SICCAS (2001). She is now a professor of SICCAS. Her research areas include the synthesis of mesoporous materials, multifunctional inorganic biomedical nanomaterials, and novel environmental catalytic materials. She has published more than 150 scientific papers which have been cited more than 4600 times by other scientists with an h-index of 38 (2014).

Jianlin Shi received his PhD degree in SICCAS (1989). He is now a professor of SICCAS. His research areas include the synthesis of mesoporous materials, mesoporous-based nano-composites, and their catalytic, biomedical and optical applications. He has published more than 300 scientific papers which have been cited more than 12,000 times by other scientists with an h-index of 59 (2014).

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Mou, J., Chen, Y., Ma, M. et al. Facile synthesis of liposome/Cu2−x S-based nanocomposite for multimodal imaging and photothermal therapy. Sci. China Mater. 58, 294–301 (2015). https://doi.org/10.1007/s40843-015-0044-3

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