Abstract
In this paper, we consider a nonlinear cancer invasion mathematical model with proliferation, growth and haptotaxis effects. We obtain lower bounds for the finite-time blow-up of solutions of the considered system with nonlinear diffusion operator when blow-up occurs. We have assumed both the Dirichlet and Neumann boundary conditions in \({\mathbb {R}}^n, n\ge 2\) to attain the desire result.
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Anderson, A.R.A.: A hybrid mathematical model of solid tumor invasion: the importance of cell adhesion. Math. Med. Biol. 22, 163–186 (2005)
Bao, A., Song, X.: Bounds for the blowup time of the solutions to quasi-linear parabolic problems. Z. Angew. Math. Phys. 65, 115–123 (2014)
Bhuvaneswari, V., Shangerganesh, L., Balachandran, K.: Global existence and blow up of solutions of quasilinear chemotaxis system. Math. Methods Appl. Sci. 38, 3738–3746 (2015)
Chaplain, M.A.J., Lolas, G.: Mathematical modelling of cancer cell invasion of tissue: The role of the urokinase plasminogen activation system. Math. Model. Methods Appl. Sci. 15, 1685–1734 (2005)
Chen, S., Yu, D.: Global existence and blowup solutions for quasilinear parabolic equations. J. Math. Anal. Appl. 335, 151–167 (2007)
Chen, W., Liu, Y.: Lower bound for the blow-up time for some nonlinear parabolic equations. Bound. Value Probl. 2016, 161 (2016)
Ding, J.: Global and blow-up solutions for nonlinear parabolic problems with a gradient term under Robin boundary conditions. Bound. Value Probl. 2013, 237 (2013)
Fujie, K., Senba, T.: Blowup of solutions to a two-chemical substances chemotaxis system in the critical dimension. J. Differ. Equ. 266, 942–976 (2019)
Ganesan, S., Lingeshwaran, S.: Galerkin finite element method for cancer invasion mathematical model. Comput. Math. Appl. 73, 2603–2617 (2017)
Giesselmann, J., Kolbe, N., Lukáčová-Medvi\(\breve{\text{d}}\)o\(\acute{\text{ v }}\), M., Sfakianakis, N.: Existence and uniqueness of global classical solutions to a two species cancer invasion haptotaxis model. Discrete Contin. Dyn. Syst. Ser. B 23, 4397–4431 (2018)
Hu, B., Tao, Y.: To the exclusion of blow-up in a three-dimensional chemotaxis-growth model with indirect attractant production. Math. Model. Methods Appl. Sci. 26, 2111–2128 (2016)
Li, Y., Lankeit, J.: Boundedness in a chemotaxis-haptotaxis model with nonlinear diffusion. Nonlinearity 29, 1564–1595 (2016)
Li, D., Mu, C., Yi, H.: Global boundedness in a three-dimensional chemotaxis-haptotaxis model, Computers and Mathematics with Applications. Comput. Math. Appl. 77, 2447–2462 (2019)
Lin, K., Xiang, T.: On boundedness, blow-up and convergence in a two-species and two-stimuli chemotaxis system with/without loop. Calc. Var. 59 (2020). https://doi.org/10.1007/s00526-020-01777-7
Morales-Rodrigo, C.: Local existence and uniqueness of regular solutions in a model of tissue invasion by solid tumours. Math. Comput. Model. 47, 604–613 (2008)
Payne, L.E., Schaefer, P.W.: Lower bounds for blow-up time in parabolic problems under Neumann conditions. Appl. Anal. 85, 1301–1311 (2006)
Payne, L.E., Philippin, G.A., Schaefer, P.W.: Blow-up phenomena for some nonlinear parabolic problems. Nonlinear Anal. 69, 3495–3502 (2008)
Payne, L.E., Philippin, G.A., Vernier-Piro, S.: Blow-up phenomena for a semilinear heat equation with nonlinear boundary condition II. Nonlinear Anal. 73, 971–978 (2010)
Payne, L.E., Song, J.C.: Lower bounds for blow-up in a model of chemotaxis. J. Math. Anal. Appl. 385, 672–676 (2012)
Peng, X., Shang, Y., Zheng, X.: Blow-up phenomena for some nonlinear pseudo-parabolic equations. Appl. Math. Lett. 56, 17–22 (2016)
Sashikumar, G., Shangerganesh, L.: A biophysical model of tumor invasion. Commun. Nonlinear Sci. Numer. Simul. 46, 135–152 (2017)
Sathishkumar, G., Shangerganesh, L., Karthikeyan, S.: Lower bounds for the finite-time blow-up of solutions of a cancer invasion model. Electron. J. Qual. Theory Differ. Equ. 12, 1–13 (2019)
Shangerganesh, L., Barani Balan, N., Balachandran, K.: Existence and uniqueness of solutions of degenerate chemotaxis system. Taiwan. J. Math. 18, 1605–1622 (2014)
Shangerganesh, L., Deiva Mani, V.N., Karthikeyan, S.: Existence of global weak solutions for cancer invasion parabolic system with nonlinear diffusion. Commun. Appl. Anal. 21, 607–629 (2017)
Shangerganesh, L., Nyamoradi, N., Deiva Mani, V.N., Karthikeyan, S.: On the existence of weak solutions of nonlinear degenerate parabolic system with variable exponents. Comput. Math. Appl. 75, 322–334 (2018)
Shangerganesh, L., Nyamoradi, N., Sathishkumar, G., Karthikeyan, S.: Finite-time blow-up of solutions to a cancer invasion mathematical model with haptotaxis effects. Comput. Math. Appl. 77, 2242–2254 (2019)
Stinner, C., Surulescu, C., Winkler, M.: Global weak solutions in a PDE-ODE system modeling multiscale cancer cell invasion. SIAM J. Math. Anal. 46, 1969–2007 (2014)
Talenti, G.: Best constant in Sobolev inequality. Ann. Mat. Pura Appl. 110, 353–372 (1976)
Tao, Y.: Global existence of classical solutions to a combined chemotaxis-haptotaxis model with logistic source. J. Math. Anal. Appl. 354, 60–69 (2009)
Tao, Y.: Global existence for a haptotaxis model of cancer invasion with tissue remodeling. Nonlinear Anal. Real World Appl. 12, 418–435 (2011)
Tao, Y., Winkler, M.: A critical virus production rate for blow-up suppression in a haptotaxis model for oncolytic virotherapy. Nonlinear Anal. 198, 111870 (2020)
Walker, C., Webb, G.F.: Global existence of classical solutions for a haptotaxis model. SIAM J. Math. Anal. 38, 1694–1713 (2007)
Wang, L., Mu, C., Hu, X., Tian, Y.: Boundedness in a quasilinear chemotaxis-haptotaxis system with logistic source. Math. Methods Appl. Sci. 40, 3000–3016 (2017)
Wang, N., Song, X., Lv, X.: Estimates for the blowup time of a combustion model with nonlocal heat sources. J. Math. Anal. Appl. 436, 1180–1195 (2016)
Wang, Y.: Boundedness in the higher-dimensional chemotaxis-haptotaxis model with nonlinear diffusion. J. Differ. Equ. 260, 1975–1989 (2016)
Zheng, J.: A note on boundedness of solutions to a higher-dimensional quasi-linear chemotaxis system with logistic source. ZAMM Z. Angew. Math. Mech. 1–8 (2016). https://doi.org/10.1002/zamm.201600166
Zheng, P.: Boundedness and blow-up for a chemotaxis system with generalized volume-filling effect and logistic source. Discrete Contin. Dyn. Syst. 35, 2299–2323 (2015)
Acknowledgements
The work of the second author is supported by the University Research Fellowship of Periyar University and the work fourth author is supported by the Special Assistance Programme (SAP) of the University Grants Commission (F-510/7/DRSI/2016 (SAP-I)) and Fund for Improvement of S&T Infrastructure (FIST) of the Department of Science and Technology (SR/FST/MSI-115/2016).
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Communicated by Yong Zhou.
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Shangerganesh, L., Sathishkumar, G., Nyamoradi, N. et al. Blow-Up Phenomena of a Cancer Invasion Model with Nonlinear Diffusion and Haptotaxis Term. Bull. Malays. Math. Sci. Soc. 44, 1215–1231 (2021). https://doi.org/10.1007/s40840-020-00996-7
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DOI: https://doi.org/10.1007/s40840-020-00996-7