Abstract
Objective
To evaluate the effect of finasteride on prostate-specific antigen (PSA) in Chinese population.
Materials and methods
From Feb 2011 to Jan 2012, 83 benign prostatic hyperplasia (BPH) patients with prostate volume (PV) >30 mL were enrolled in our study. All the patients were older than 50 years and all of them received combined therapy (finasteride + doxazosin). All the patients were required for 1-year follow-up. PSA level and PV was measured at the start, 6 and 12 months, respectively.
Results
79 patients completed the follow up. PSA level reduced by approximately 40 % during finasteride therapy. We defined baseline PSA as PSA1, PSA at 6 months as PSA2, PSA at 12 months as PSA3. PSA1 was significantly correlated with PSA2/PSA1 and PSA3/PSA1. However, prostate volume was not correlated with PSA1. We divided the patients into three groups according to PSA level. Groups 1, 2, 3 represented the patients with PSA less than 2 ng/mL, between 2 and 4 ng/mL and greater than 4 ng/mL, respectively. Both the PSA2/PSA1 and the PSA3/PSA1 had significant difference among three groups. Furthermore, group 1 and group 2 both showed the fairly large data variance.
Conclusions
When baseline PSA level was greater than 4 ng/mL, the doubling rule could be used for screening. When baseline PSA level was less than 4 ng/Ml, the doubling rule might not be an accurate predictor. We can use the PSA rise from nadir or proPSA to predict prostate cancer.
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Acknowledgments
The authors wish to thank all patients for their ongoing participation in this study. The authors also wish to thank Wen-bin Guan for his contribution of specimen procession and evaluation to this article.
Funding
This study was funded by a grant from Science and Technology Commission of Shanghai Municipality (CN) (No. 134119a0600 and 14430720800).
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The authors declare that they have no conflict of interest.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of Xinhua Hospital Affiliated to Shanghai University School of Medicine and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Informed consent was obtained from all individual participants included in the study.
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D. Xu and J. Ding contributed equally to this article.
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Xu, D., Ding, J., Zhu, Y. et al. The new insight of prostate-specific antigen reduction during finasteride therapy in aging men. Aging Clin Exp Res 28, 1237–1241 (2016). https://doi.org/10.1007/s40520-015-0512-3
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DOI: https://doi.org/10.1007/s40520-015-0512-3