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The role of 18F-FDG PET/CT radiomics in lymphoma

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Abstract

Purpose

To systematically review the applications of texture analysis and radiomics applied to 18F-FDG PET/CT in lymphoma.

Methods

According to the PRISMA statement, a comprehensive research of the literature was performed to find relevant articles on the applications of texture analysis and radiomics to 18F-FDG PET/CT in lymphomas. Information on the general, methodological and clinical aspects of all included studies was collected. Studies were divided into three groups depending on their clinical aim: (1) outcome prediction; (2) histological differentiation from other malignancies; (3) assessment of bone marrow involvement.

Results

Twenty-seven full-text papers were selected for final review, 17 of which aimed to predict outcome, prognosis or survival, 7 tried to differentiate lymphoma from other malignancies and 3 studies aimed to assess bone marrow involvement.

Conclusions

18F-FDG PET/CT textural and radiomic features may be useful tools in lymphoma for histological prediction, prognostic assessment and bone marrow involvement definition. Further studies are needed to integrate radiomics in clinical multi-omic models.

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Funding

Salvatore Annunziata is funded by Ministero della Salute through Ricerca Finalizzata 2019, for a research project about a large retrospective ontology about PET/CT radiomics in lymphoma (PERL, 2021–2024; grant number: GR-2019-12370372).

Author information

Authors and Affiliations

  1. Candiolo Cancer Institute, FPO – IRCCS, Candiolo, TO, Italy

    Alessio Rizzo & Manuela Racca

  2. Section of Nuclear Medicine, University Department of Radiological Sciences and Hematology, Università Cattolica del Sacro Cuore, Rome, Italy

    Elizabeth Katherine Anna Triumbari

  3. Dipartimento di Scienze Cliniche e Sperimentali dell’Università degli Studi di Brescia, Brescia, Italy

    Roberto Gatta

  4. Unità di Radioterapia, Radiomics, Dipartimento Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico A. Gemelli IRCCS, Roma, Italia

    Roberto Gatta & Luca Boldrini

  5. Division of General and Pediatric Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

    Marius Mayerhoefer

  6. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Marius Mayerhoefer

  7. Unità di Medicina Nucleare, TracerGLab, Dipartimento Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico A. Gemelli IRCCS, Largo Agostino Gemelli 8, 00168, Rome, Italy

    Salvatore Annunziata

Authors
  1. Alessio Rizzo
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  2. Elizabeth Katherine Anna Triumbari
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  3. Roberto Gatta
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  4. Luca Boldrini
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  5. Manuela Racca
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  6. Marius Mayerhoefer
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  7. Salvatore Annunziata
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Contributions

AR and EKT literature search and review, writing; MR and MM writing and editing; RG, LB, SA content planning and editing.

Corresponding author

Correspondence to Salvatore Annunziata.

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Rizzo, A., Triumbari, E.K.A., Gatta, R. et al. The role of 18F-FDG PET/CT radiomics in lymphoma. Clin Transl Imaging 9, 589–598 (2021). https://doi.org/10.1007/s40336-021-00451-y

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  • DOI: https://doi.org/10.1007/s40336-021-00451-y

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