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New technologies in radioguided surgery in complex anatomic areas

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Abstract

Sentinel lymph node biopsy (SLNB) is the most common radioguided surgery procedure and standard of care for lymph node staging in clinically node-negative patients with melanoma and breast cancer. While SLNB has also emerged as a potential alternative to lymph node dissection for staging in patients with other solid malignancies, its use for this purpose has to date not been widely accepted owing to technical limitations in complex anatomic areas such as the head and neck and the pelvic region. However, new technologies have recently been developed to overcome these limitations. This review focuses on the new technologies that improve SLN localization in complex anatomic areas, including new diagnostic tracers (99mTc-tilmanocept and hybrid tracers), preoperative SPECT/CT imaging, and scintigraphic three-dimensional intraoperative imaging techniques.

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Acknowledgments

We thank Rick Mills for language editing.

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Authors and Affiliations

  1. Department of Nuclear Medicine, University Hospital of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany

    Christina Bluemel & Ken Herrmann

  2. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, USA

    Ken Herrmann

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  1. Christina Bluemel
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Correspondence to Christina Bluemel.

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Conflict of interest

KH is a co-founder of Surgicye GmbH (Munich, Germany), the company that owns and manufactures the fhSPECT system discussed in this manuscript (declipse®SPECT; SurgicEye, Munich, Germany). CB has no conflicts of interest.

Research involving human participants and/or animals

Not applicable—the manuscript is a review article. Original research cited in the article and performed by one of the authors was approved by the local ethics committee, and all patients signed written informed consent forms.

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Bluemel, C., Herrmann, K. New technologies in radioguided surgery in complex anatomic areas. Clin Transl Imaging 4, 329–341 (2016). https://doi.org/10.1007/s40336-016-0175-x

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