Skip to main content
Log in

Manage chronic pruritus in the elderly with various agents depending on the pathophysiology and aetiology of the condition

  • Disease Management
  • Published:
Drugs & Therapy Perspectives Aims and scope Submit manuscript

Abstract

Management of chronic pruritus in elderly patients requires an understanding of the potential pathophysiological causes. Chronic itch may be caused by xerosis, immunosenescence, neuropathy, skin diseases, systemic illnesses and psychogenic conditions. Several topical, systemic and psychological treatments are available. An individualized treatment approach should be adopted, taking into account the presence of polypharmacy, co-morbidities, physical and cognitive limitations, as well as the potential risk of adverse effects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Valdes-Rodriguez R, Stull C, Yosipovitch G. Chronic pruritus in the elderly: pathophysiology, diagnosis and management. Drugs Aging. 2015;32(3):201–15.

    Article  CAS  PubMed  Google Scholar 

  2. Chinniah N, Gupta M. Pruritus in the elderly: a guide to assessment and management. Aust Fam Physician. 2014;43(10):710–3.

    PubMed  Google Scholar 

  3. Berger TG, Shive M, Harper GM. Pruritus in the older patient: a clinical review. JAMA. 2013;310(22):2443–50.

    Article  CAS  PubMed  Google Scholar 

  4. Berger TG, Steinhoff M. Pruritus in elderly patients: eruptions of senescence. Semin Cutan Med Surg. 2011;30(2):113–7.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Reich A, Ständer S, Szepietowski JC. Pruritus in the elderly. Clin Dermatol. 2011;29:15–23.

    Article  PubMed  Google Scholar 

  6. Yosipovitch G. Dry skin and impairment of barrier function associated with itch: new insights. Int J Cosmet Sci. 2004;26(1):1–7.

    Article  CAS  PubMed  Google Scholar 

  7. Long CC, Marks R. Stratum corneum changes in patients with senile pruritus. J Am Acad Dermatol. 1992;27(4):560–4.

    Article  CAS  PubMed  Google Scholar 

  8. Jensen JM, Forl M, Winoto-Morbach S, et al. Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging. Exp Dermatol. 2005;14(8):609–18.

    Article  CAS  PubMed  Google Scholar 

  9. Stumpf A, Ständer S. Neuropathic itch: diagnosis and management. Dermatol Ther. 2013;26(2):104–9.

    Article  PubMed  Google Scholar 

  10. Yosipovitch G, Samuel LS. Neuropathic and psychogenic itch. Dermatol Ther. 2008;21(1):32–41.

    Article  PubMed  Google Scholar 

  11. Valdes-Rodriguez R, Mollanazar NK, Gonzalez-Muro J, et al. Itch prevalence and characteristics in a Hispanic geriatric population: a comprehensive study using a standardized itch questionnaire. Acta Derm Venereol. 2015;95(4):417–21.

    PubMed  Google Scholar 

  12. Reich A, Ständer S, Szepietowski JC. Drug-induced pruritus: a review. Acta Derm Venereol. 2009;89(3):236–44.

    Article  PubMed  Google Scholar 

  13. Yosipovitch G, Bernhard JD. Clinical practice: chronic pruritus. N Engl J Med. 2013;368(17):1625–34.

    Article  CAS  PubMed  Google Scholar 

  14. Weisshaar E, Weiss M, Mettang T, et al. Paraneoplastic itch: an expert position statement of the Special Interest Group (SIG) of the International Forum on the Study of Itch (IFSI). Acta Derm Venereol. 2015;95(3):261–5.

    Article  PubMed  Google Scholar 

  15. Weisshaar E. Intractable chronic pruritus in a 67-year-old man. Acta Derm Venereol. 2008;88(5):488–90.

    Article  PubMed  Google Scholar 

  16. Endo JO, Wong JW, Norman RA, Geriatric dermatology: part I. Geriatric pharmacology for the dermatologist. J Am Acad Dermatol. 2013;68(4):521.e1–10.

  17. Kim KH, Lee MS, Choi SM. Acupuncture for treating uremic pruritus in patients with end-stage renal disease: a systematic review. J Pain Symptom Manag. 2010;40(1):117–25.

    Article  Google Scholar 

  18. Patel T, Yosipovitch G. The management of chronic pruritus in the elderly. Skin Therapy Lett. 2010;15(8):5–9.

    PubMed  Google Scholar 

Download references

Disclosure

This article was adapted from Drugs and Aging 2015;32(3):201–15 [1] by salaried employees of Adis/Springer, and was not supported by any external funding.

Author information

Authors and Affiliations

Consortia

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Adis Medical Writers. Manage chronic pruritus in the elderly with various agents depending on the pathophysiology and aetiology of the condition. Drugs Ther Perspect 31, 302–306 (2015). https://doi.org/10.1007/s40267-015-0223-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40267-015-0223-z

Keywords

Navigation