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The Role of Interleukin-17A in Psoriatic Disease

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Abstract

The pathogenic mechanisms of specific immune-mediated inflammatory diseases (IMIDs) are not fully understood, but are thought to involve activated T cells with the release of pro-inflammatory cytokines. Understanding the autoimmune inflammatory pathways has led to the development of biological agents that target specific components of effector immune mechanisms. Despite the availability of many effective drugs, a large proportion of patients with moderate to severe IMID do not receive adequate treatment, and many therapies show decreased efficacy over time. Therefore, there is a need for new therapies. One subset of T helper cells, Th17, and the cytokine interleukin-17 (IL-17) play a central role in the pathophysiology of autoimmune diseases such as psoriasis. IL-17 is involved in the modulation of pro-inflammatory cytokines, haematopoietic growth factors, antimicrobial peptides, chemokines, and molecules involved in tissue remodelling; the inflammatory cascades triggered by Th17 cells and IL-17 itself, when unregulated, can result in widespread inflammation-related damage. Evidence of increased Th17 activity and high levels of IL-17 has been found in psoriasis, as well as other inflammatory conditions, thereby signalling the potential utility of IL-17 as a therapeutic target. Clinical trials investigating IL-17 inhibitors, such as secukinumab, in patients with psoriatic disease have reported no significant safety concerns so far. It is hoped that these agents will improve the long-term prognosis of patients with these debilitating disorders.

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Acknowledgments

Thanks to Elisabetta Parretta and Concetta Rafaniello for their collaboration on the pharmacological aspects of this work.

We wish to thank Mary Hines and Sheridan Henness, PhD, of Springer Healthcare Communications, for medical writing assistance. This assistance was funded by Novartis Pharma, Italy.

SA has served as a consultant and/or paid speaker for and/or participated in clinical trials sponsored by companies that manufacture drugs used for the treatment of rheumatic diseases, including Amgen, Eli-Lilly, Merck Sharp & Dohme and Novartis.

AC has served as a consultant and/or paid speaker for and/or participated in clinical trials sponsored by companies that manufacture drugs used for the treatment of psoriasis, including Abbott, Novartis and Pfizer.

FR has served as a paid speaker and consultant on advisory boards for Allergan, GFK, Italfarmaco, Novartis, Otsuka Pharmaceutical and Sanofi-Aventis.

GG has served as a consultant and/or paid speaker for and/or participated in clinical trials sponsored by companies that manufacture drugs used for the treatment of psoriasis, including AbbVie, Actelion, Almirall, Celgene, Eli-Lilly, Janssen, LEO Pharma, Merck Sharp & Dohme, Novartis and Pfizer.

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Authors and Affiliations

  1. Section of Rheumatology, Department of Medicine, University of Verona, Verona, Italy

    Silvano Adami

  2. Laboratory of Experimental Immunology, Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Rome, Italy

    Andrea Cavani

  3. Section of Pharmacology, Department of Experimental Medicine, Second University of Naples, Naples, Italy

    Francesco Rossi

  4. Section of Dermatology and Venereology, Department of Medicine, University of Verona, Piazzale A. Stefani 1, 37126, Verona, Italy

    Giampiero Girolomoni

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  1. Silvano Adami
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  2. Andrea Cavani
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  3. Francesco Rossi
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  4. Giampiero Girolomoni
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Correspondence to Giampiero Girolomoni.

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Adami, S., Cavani, A., Rossi, F. et al. The Role of Interleukin-17A in Psoriatic Disease. BioDrugs 28, 487–497 (2014). https://doi.org/10.1007/s40259-014-0098-x

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