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Ball-milling Synthesis of Single-atom Cu Anchored on N-Doped Carbon for Mimicking Peroxidase

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Chemical Research in Chinese Universities Aims and scope

Abstract

Nanozymes have shown great potential for life sciences owing to their distinct advantages, such as low cost and high stability, compared with natural enzymes. Despite significant progress, state-of-art nanozymes commonly suffer from relatively low specific activities. Herein, we propose a promising to address this issue by creating single-atom nanozymes. A ball-milling-assisted strategy has been developed to induce the transformation of Cu species from bulk to single atoms. The highly-simplified steps allow a large-scale synthesis, that over 4.2 g of single-atom Cu−N doped carbon nanozymes can be achieved in one pot. It exhibits a remarkably improved peroxidase-like activity and stability compared with N doped C anchored Cu nanoparticles. Further experimental firmly reveals the crucial role of the single-atom Cu site that can generate more active ·OH species for boosting the catalytic process.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 52072142) and the Key Projects of Jilin Province Science and Technology Development Plan, China(No.20220203148SF).

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Authors and Affiliations

  1. Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130021, P. R. China

    Henan Xu, Shaopeng Zhang, Wei Li & Daguang Wang

  2. College of Chemistry, Jilin University, Changchun, 130012, P. R. China

    Lingling Zhang, Wei Li & Zhan Shi

  3. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China

    Lingling Zhang, Huilin Wang, Xiao Wang & Shuyan Song

Authors
  1. Henan Xu
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  2. Lingling Zhang
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  3. Huilin Wang
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  4. Shaopeng Zhang
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  5. Wei Li
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  6. Xiao Wang
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  7. Shuyan Song
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  8. Daguang Wang
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  9. Zhan Shi
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Corresponding authors

Correspondence to Wei Li, Xiao Wang or Daguang Wang.

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Xu, H., Zhang, L., Wang, H. et al. Ball-milling Synthesis of Single-atom Cu Anchored on N-Doped Carbon for Mimicking Peroxidase. Chem. Res. Chin. Univ. 39, 948–953 (2023). https://doi.org/10.1007/s40242-023-2305-0

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  • DOI: https://doi.org/10.1007/s40242-023-2305-0

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