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The Regulatory Role of miRNAs in Ethanol-induced TLR4 Activation and Neuroinflammation

  • The Pathobiology of Alcohol Consumption (P Molina and M Ronis, Section Editors)
  • Published:
Current Pathobiology Reports

Abstract

Purpose of Review

Alcohol is a neurotoxic compound and its abuse can induce brain damage and neurodegeneration. Evidence from the last decade demonstrates the critical role of the innate immune system in neuroinflammation associated with alcohol abuse. In this review, we discuss the role of miRNAs as regulators of immune Toll-like receptors (TLR4), the neuroimmune response associated with alcohol abuse, and the importance of glial extracellular vesicles in amplifying neuroinflammation.

Recent Findings

Current studies demonstrate the role of glial extracellular vesicles/exosomes in extending neuroinflammation, and the importance of miRNAs as key regulators of different biological functions. However, dysregulation of miRNAs also participates in neurological and neurodegenerative diseases associated with neuroinflammation. Recent findings indicate the possibility of circulating miRNAs being used as biomarkers to screen neurological and neuroinflammatory disorders as early diagnosis and therapy.

Summary

This article highlights the role of miRNAs in regulating neuroinflammation associated with alcohol abuse and the importance of glial extracellular vesicles/exosomes in extending neuroinflammation.

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Authors and Affiliations

  1. Department of Molecular and Cellular Pathology of Alcohol, Príncipe Felipe Research Center, C/ Eduardo Primo Yúfera 3, 46012, Valencia, Spain

    María Pascual, Juan R. Ureña-Peralta & Consuelo Guerri

  2. Department of Physiology, School of Medicine and Dentistry, University of Valencia, Valencia, Spain

    María Pascual

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  1. María Pascual
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Pascual, M., Ureña-Peralta, J.R. & Guerri, C. The Regulatory Role of miRNAs in Ethanol-induced TLR4 Activation and Neuroinflammation. Curr Pathobiol Rep 8, 37–45 (2020). https://doi.org/10.1007/s40139-020-00208-8

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