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Understanding Molecules that Mediate Leukocyte Extravasation

  • Wound Healing and Tissue Repair ( C Yates and R Mota, Section Editors)
  • Published:
Current Pathobiology Reports

Abstract

Purpose of Review

Getting leukocytes to the site of inflammation is extremely important for maintaining homeostasis. Over time, leukocyte extravasation is resolved; however, in the case of chronic inflammatory diseases, it is not. When left unresolved, persistent leukocyte infiltration is detrimental to the host. Understanding how leukocytes get out of circulation and into the tissue puts us closer to combating these diseases. This review focuses on the molecules regulating leukocyte extravasation.

Recent Findings

There are multiple pathways regulating leukocyte transmigration. Targeted recycling of membrane from the lateral border recycling compartment is required for leukocyte extravasation. Differences in leukocyte phenotypes may contribute to different transmigration rates and extent.

Summary

Leukocyte transmigration is regulated by a multitude of molecules. How these molecules interact to coordinate the process is the subject of ongoing research. Characterization of these pathways will be useful in developing therapies for chronic inflammation.

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Acknowledgments

Figure 1 was designed with the assistance of Dr. David Sullivan in our lab.

Funding

This work was funded by NIH grants F31 HL13135504, R01 HL046849, and R01 HL064774.

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  1. Department of Pathology, Feinberg School of Medicine, Northwestern University, Ward Building, Rm 3-126, 303 East Chicago, Chicago, IL, 60611-3008, USA

    Nakisha S. Rutledge & William A. Muller

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  1. Nakisha S. Rutledge
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Rutledge, N.S., Muller, W.A. Understanding Molecules that Mediate Leukocyte Extravasation. Curr Pathobiol Rep 8, 25–35 (2020). https://doi.org/10.1007/s40139-020-00207-9

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