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Human Papillomavirus in Sinonasal Malignancies

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Abstract

Purpose of Review

The purpose of this review is to convey to the reader the most recent literature on the association between human papillomavirus (HPV) and sinonasal malignancies.

Recent Findings

In recent years, HPV has been recognized as an etiological factor in sinonasal squamous cell carcinomas (SN-SCCs). Studies find that 28% of SN-SCCs are HPV positive, mostly HPV-16 and -18. Inverted papillomas (IPs), sinonasal benign epithelial neoplasms, have also been associated with HPV and by extension malignant transformation to SCC. Despite repeated detection of HPV in IPs, the association remains controversial. Furthermore, a new unique histological tumor type, HPV-related multiphenotypic sinonasal carcinoma, has been described. Studies indicate that HPV-positive sinonasal malignancies have a decreased mortality compared to HPV-negative tumors, much like other head and neck carcinomas.

Summary

A significant proportion of sinonasal malignancies are caused by HPV. Several subtypes have been found, but further studies on clinical outcome are needed.

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  1. Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital, Copenhagen, Denmark

    M. Hebsgaard, P. Eriksen & C. von Buchwald

  2. Department of Ophthalmology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

    I. Ramberg

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Hebsgaard, M., Eriksen, P., Ramberg, I. et al. Human Papillomavirus in Sinonasal Malignancies. Curr Otorhinolaryngol Rep 11, 109–116 (2023). https://doi.org/10.1007/s40136-023-00448-3

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