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Anti-arthritic Effect of Combretum Platypterum (Welw) Hutch & Dalziel Root Aqueous Extract on Arthritic Wistar Rats Paw

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Proceedings of the National Academy of Sciences, India Section B: Biological Sciences Aims and scope Submit manuscript

Abstract

Combretum platypterum has several ethnomedicinal benefit used in the treatment of arthritis, lumps, conjunctivitis, swellings, backache, malaria, fever, helminthiasis and diarrhea. This study is aimed at evaluating the anti-arthritis property of C. platypterum root aqueous extract. The anti-arthritis effect of the root aqueous extract was investigated using formaldehyde-induced arthritis and Complete Freund’s adjuvant-induced arthritis models in rats. The root aqueous extract at graded doses (50, 100, 200 and 400 mg/kg) showed a significant reduction in the diameter of formaldehyde-induced arthritis rat paw at day 10 (1.92, 1.92, 1.03 and 1.05 mm) and day 28 (1.76, 1.66, 1.34 and 1.77 mm) when compared with the arthritic control (negative group) (2.95 mm) (p < 0.05). The results obtained from the percentage inhibition showed at day 10 (67.80, 52.08, 65.08 and 64.41%) and day 28 (35.06, 38.75, 49.82 and 34.69%) had a comparative effect with the standard drug (2 mg/kg dexamethasone) at days 10 and 28 (67.46 and 70.11%). Treatment from the root aqueous extract and 0.7 mg/kg Methotrexate (Mez) in complete Freund’s adjuvant-induced arthritis had a significant decrease in the paw diameter when compared with arthritis control (p < 0.05). The ankle weight, Erythrocyte Sedimentary Rate level and malondialdehyde level of the treatment groups elicited a significant decrease in Complete Freund’s adjuvant induced-arthritis (p < 0.05). The extract exhibited a significant increases in superoxide dismutase on Complete Freund’s adjuvant-induced arthritis in Wistar rats when compared with the arthritis control (p < 0.05). This study showed that C. platypterum root extract had anti-arthritis property, which conform to its folklore benefits.

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Acknowledgements

Our intense appreciation goes to Mr. Kelvin Odega of the Department of Morbid Anatomy, University of Benin Teaching Hospital, Mr Dialet in the Department of haematology, University of Benin Teaching Hospital for the ESR analysis, Dr. Agu for the antioxidant study in the Department of Medical Biochemistry, University of Benin.

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Authors and Affiliations

  1. Department of Plant and Biotechnology, Faculty of Life Sciences, University of Benin, Benin City, 300001, Nigeria

    MacDonald Idu & Benjamin Ogunma Gabriel

  2. Department of Science Laboratory Technology, Faculty of Life Sciences, University of Benin, Benin CityBenin City, 300001, Nigeria

    Dickson Onyenmulo Uwaya, Augustine Nnaemeka Eboh & Benjamin Ogunma Gabriel

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Correspondence to Benjamin Ogunma Gabriel.

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Significant Statement: We the author proposed to submit our manuscript to your reputable and reliable journal due to its high impact of research findings as a potent anti-arthritis effect and a copy of this manuscript is not under consideration or published elsewhere. No issue concerning the Journal policy no potential competing interest. All authors have agreed for the publication of this manuscript.

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Uwaya, D.O., Idu, M., Eboh, A.N. et al. Anti-arthritic Effect of Combretum Platypterum (Welw) Hutch & Dalziel Root Aqueous Extract on Arthritic Wistar Rats Paw. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 94, 169–176 (2024). https://doi.org/10.1007/s40011-023-01518-8

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