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Practical approaches on the long-acting injections

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Abstract

Background

Over the last several decades, long-acting injections have been studied in order to overcome such problems as low bioavailability in the oral route, the short durations of action in conventional injection, and the poor medication adherence in patients.

Area covered

The authors classified long-acting injections into three categories, namely, molecular modification, nanovehicle carriers, and stimuli-responsive hydrogels. The mechanisms and practical cases of these long acting injectable formulations, including conventional and recent technologies, were described and discussed in this review.

Expert opinion

Long-acting injection formulations has been proven to be useful from a number of preclinical and clinical studies. Therefore, the long-acting injection technologies can be promising strategy for precision and personalized medicine if the characteristics of formulation such as extended release and the drug-targeting are used appropriately.

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Acknowledgements

This work was supported by the 2018 Inje University research grant.

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Author notes

  1. Yu-Chul Kim and Kyoung Ah Min have contributed equally to this work.

Authors and Affiliations

  1. College of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje University, 197 Inje-ro, Gimhae, 50834, Republic of Korea

    Kyoung Ah Min, Tae Young Ahn, Jae Hyeok Min, Byeong Eun Yu & Kwan Hyung Cho

  2. Department of Pharmaceutical Engineering, Inje University, 197 Inje-ro, Gimhae, 50834, Republic of Korea

    Yu-Chul Kim & Dong-Jin Jang

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  1. Yu-Chul Kim
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Kim, YC., Min, K.A., Jang, DJ. et al. Practical approaches on the long-acting injections. J. Pharm. Investig. 50, 147–157 (2020). https://doi.org/10.1007/s40005-019-00452-0

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