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Combination antibiotic therapy for the treatment of infective endocarditis due to enterococci

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Abstract

Introduction

Enterococci are common causes of infective endocarditis (IE) in both health care and community-based setting. Enterococcal IE requires bactericidal therapy for an optimal outcome. For decades, cell-wall-active antimicrobial agents (penicillins or vancomycin) in combination with aminoglycosides were the cornerstone of the treatment; however, the emergence of antibiotic resistance has significantly reduced the efficacy of these regimens.

Materials and methods

Data for this review were identified by searches of MEDLINE and references from relevant articles on antibiotic combination regimens for the treatment of enterococcal IE. Abstracts presented in scientific conferences were not searched for.

Conclusion

New effective and safe combination treatments, including double-β-lactam and daptomycin/β-lactam combination, are proving useful for the management of IE due to enterococci.

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Authors and Affiliations

  1. Department of Infectious Diseases, Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi d’Aragona, Università di Salerno, Largo Città di Ippocrate, 84131, Salerno, Italy

    Sebastiano Leone, Silvana Noviello & Silvano Esposito

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  1. Sebastiano Leone
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  2. Silvana Noviello
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  3. Silvano Esposito
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Correspondence to Sebastiano Leone or Silvano Esposito.

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Leone, S., Noviello, S. & Esposito, S. Combination antibiotic therapy for the treatment of infective endocarditis due to enterococci. Infection 44, 273–281 (2016). https://doi.org/10.1007/s15010-015-0836-0

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  • DOI: https://doi.org/10.1007/s15010-015-0836-0

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