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Effects of estrogen on intracellular calcium-related T-lymphocyte function

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Tissue Engineering and Regenerative Medicine Aims and scope

Abstract

Regulation of immune cell function is an important in the field of hormone-related tissue engineering and regenerative medicine. In this sense, hormonal regulation of immune cell function is a critical issue to be solved. It has been known that ovarian sex hormone play an important roles in immune function, however, little has been known whether estrogen affects T-lymphocyte function. Human Jurkat T cells were treated with estradiol (E2) at concentrations of 0, 10, 100, 1000 ng/mL, and calcium response was evaluated. Intracellular calcium concentrations after Fura-2 acetoxymethyl ester treatment show an increasing trend at higher E2 concentrations although these alterations did not reach a statistical significance. The expression of calcium channel-related gene CACNA1C did not show any significant changes according to the concentration of E2. Taken together, estrogen has an implication as a possible hormonal regulator of intracellular calcium release in human Jurkat T cells via non-genomic pathway. Further studies are necessary to investigate the combined effects of sex hormones and cytokines in both T- and B-lymphocytes.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea

    Yoon Young Kim, Hoon Kim, Seung-Yup Ku, Chang Suk Suh, Seok Hyun Kim & Young Min Choi

  2. Department of Physiology, Seoul National University College of Medicine, Seoul, Korea

    Sung Joon Kim

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  1. Yoon Young Kim
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  2. Hoon Kim
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  3. Seung-Yup Ku
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  4. Chang Suk Suh
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  5. Seok Hyun Kim
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  6. Young Min Choi
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  7. Sung Joon Kim
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Correspondence to Seung-Yup Ku.

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These authors contributed equally to this work.

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Kim, Y.Y., Kim, H., Ku, SY. et al. Effects of estrogen on intracellular calcium-related T-lymphocyte function. Tissue Eng Regen Med 13, 270–273 (2016). https://doi.org/10.1007/s13770-015-9070-1

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  • DOI: https://doi.org/10.1007/s13770-015-9070-1

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